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TyeA protein domain

In molecular biology, the protein domain TyeA is short for Translocation of Yops into eukaryotic cells A. It controls the release of Yersinia outer proteins. More it interacts with the bacterial protein YopN via hydrophobic residues located on the helices; this protein domain is involved in the control of Yop release. This helps it to evade the host's immune system. Yersinia spp. Do this by injecting the effector Yersinia outer proteins into the target cell. Involved in Yop secretion are YopN and LcrG. TyeA is required for translocation of YopE and YopH. TyeA interacts with YopD, a component of the translocation apparatus; this shows the complex which recognizes eukaryotic cells and controls Yop secretion is actively involved in translocation. Like YopN, TyeA is localized at the bacterial surface; the structure of TyeA is composed of two pairs of parallel alpha-helices. Association of TyeA with the C terminus of YopN is accompanied by conformational changes in both polypeptides that create order out of disorder: the resulting structure serves as an impediment to type III secretion of YopN

Siberian ibex

The Siberian ibex is a species of ibex that lives in central Asia. It has traditionally been treated as a subspecies of the Alpine ibex, whether it is distinct from other ibex is still not clear, it is the longest and heaviest member of the genus Capra, though its shoulder height is surpassed by the markhor. Siberian ibexes are large and built goats, although individual sizes vary greatly. Males are between 88 and 110 cm in shoulder height, weigh between 60 and 130 kg. Females are noticeably smaller, with heights between 67 and 92 cm, weights between 34 and 56 kg; the nose is straight in profile, the neck short, the back straight. The neck is particularly thick and muscular in males, but much less so in females. Both sexes have beards, although the male's beard is more pronounced, those of females are sometimes absent altogether. Both sexes possess a large scent gland, about 3 cm across, beneath the tail; the female's horns are small, grey-brown in colour, measuring an average of 27 cm long. Those of fully-grown males are black and measure about 115 cm, although in extreme cases they can grow to 148 cm.

Both sexes have circular rings around their horns that represent annual growth, but males have large transverse ridges along the front surface. The exact shape of the horns varies between individuals; the colouration is variable, from dark brown to light tan, with some reddish individuals. There is a stripe of darker hair down the centre of the back and onto the tail, some males have saddle-like patches on the back in the winter; the undersides are paler, and, in the winter, mature males becoming much darker with white patches. Females and infants are more bland in colour than the adult males, do not always have the stripe down the back. Siberian ibexes moult between April and July, developing their paler summer coat, which continues to grow and become darker as the year progresses, reaching the full winter condition around December. Though some recent authorities treat the species as monotypic, others have recognized four subspecies, based on differences in total size, size of horns and colour of pelage: C. s. sibirica - Sayan Mountains C. s. alaiana - Alay Mountains C. s. hagenbecki - western Mongolia C. s. sakeen - Pamir Mountains, western Himalayas, Afghanistan and Pakistan The rut takes place from late October to early January.

During the rut, the males spend considerable effort courting females, they are emaciated from lack of grazing by the time it ends. Courtship lasts for over 30 minutes, consists of licking, ritualised postures, flehmen if the female urinates. Males compete for dominance during the rut, rearing up on their hind legs and clashing their horns together. Gestation lasts 170 to 180 days, results in the birth of a single kid, although twins occur in up to 14% of births, triplets are born on rare occasions. Newborn kids weigh about 3 kg, grow during their first year; the horns are visible after about three to four weeks. They begin to eat grass as little as eight days after birth, but do not do so until they are about one month old, are not weaned until six months. Males do not reach their full adult size for nine years. Females first breed in their second year. Males live for ten years in the wild, females for up to seventeen years, they have been reported to live for up to 22 years in captivity. Living at high elevations, sometimes at the vegetation line and well above the tree line, Siberian ibexes seek out lower slopes during the winter in search of food.

They have been known to seek out tree lines on hot days, but they do not enter forested areas, preferring to return to their alpine habitat when the weather has cooled. When snow is heavy, they have to paw away snow to reach the vegetation below, their diet consists of alpine grasses and herbs. During spring and summer and sedges form the bulk of their diet, while during winter they eat more tall herbs, the twigs and needles of trees such as aspen, spruce and willow. During the summer, they visit salt licks. Herds vary in size depending on the local population. Outside of the rut, most herds are single-sex, although some mixed-sex herds persist throughout the year. Herds spend much of the day grazing; the main predators of Siberian ibex are wolves, snow leopards, brown bears. Siberian ibexes live above the tree line, in areas of steep slopes and rocky scree, their habitat consists of a mixture of high altitude tundra, alpine meadows, regions of semidesert. In the Gobi Desert, they may be found on hills as low as 700 m, but they are more found between about 2,000 and 5,000 metres in summer, descending to lower, sometimes sparsely forested, slopes during the winter.

In Tajikistan, the ibex distribution is controlled by climatic variables such as seasonal temperature and precipitation of warmest quarter. Most Siberian ibexes are seen in central and northern Asia, Afghanistan and northern China, north-western India, south-eastern Kazakhstan, Tajikistan, eastern Uzbekistan, northern Pakistan, south-central Russia. Siberian Ibex at Animal Diversity Web

Electoral district of Hinchinbrook

Hinchinbrook is an electoral district of the Legislative Assembly in the Australian state of Queensland. A rural electorate, the district in its present form is a narrow coastal strip running from just south of Tully to the northern fringes of Townsville. Prior to the 2017 redistribution Hinchinbrook had spanned just south of Innisfail and included the towns of Mission Beach and Tully. Hinchinbrook now includes the towns of Cardwell, Ingham and includes the Northern Beaches suburbs of Townsville such as Bushland Beach; the electorate was first contested in 1950 and until the 2017 election had been held by the Country Party and its successor parties continuously for over half a century. Green, Antony. "Electorate Profile". Australian Broadcasting Corporation

Roman dictator

A dictator was a magistrate of the Roman Republic, entrusted with the full authority of the state to deal with a military emergency or to undertake a specific duty. All other magistrates were subordinate to his imperium, the right of the plebeian tribunes to veto his actions or of the people to appeal from them was limited. However, in order to prevent the dictatorship from threatening the state itself, severe limitations were placed upon its powers: a dictator could only act within his intended sphere of authority. Dictators were appointed from the earliest period of the Republic down to the Second Punic War, but the magistracy went into abeyance for over a century, until it was revived in a modified form, first by Sulla between 82 and 79 BC, by Julius Caesar between 49 and 44 BC; the office was formally abolished after the death of Caesar, not revived under the Empire. With the abolition of the Roman monarchy in 509 BC, the imperium, or executive power, of the king was divided between two annually-elected magistrates, known as praetors.

In time they would come to be known as consuls, although not until the creation of a third, junior praetor in 367 BC. Neither consul was superior to the other, the decisions of one could be appealed to the other, their insignia were the toga praetexta and the sella curulis, each was attended by an escort of twelve lictors, each of whom bore the fasces, a bundle of rods topped by an axe. After several years, the fear of impending war with both the Sabines and the Latin League, combined with widespread suspicion that one or both of the consuls favoured the restoration of the monarchy, led to the call for a praetor maximus, or dictator, akin to the supreme magistrate of other Latin towns. According to most authorities, the first dictator was Titus Lartius in 501 BC, who appointed Spurius Cassius his magister equitum. Although there are indications that the term praetor maximus may have been used in the earliest period, the official title of the dictator throughout the history of the Republic was magister populi, or "master of the infantry".

His lieutenant, the magister equitum, was the "master of the horse". However, the use of dictator to refer to the magister populi seems to have been widespread from a early period; the appointment of a dictator involved three steps: first, the Senate would issue a decree known as a senatus consultum, authorizing one of the consuls to nominate a dictator. Technically, a senatus consultum was advisory, did not have the force of law, but in practice it was nearly always followed. Either consul could nominate a dictator. If both consuls were available, the dictator was chosen by agreement; the Comitia Curiata would be called upon to confer imperium on the dictator through the passage of a law known as a lex curiata de imperio. A dictator could be nominated for causa; the three most common were rei gerundae causa, "for the matter to be done", used in the case of dictators appointed to hold a military command against a specific enemy. Other reasons included seditionis sedandae causa; these reasons could be combined, but are not always recorded or stated in ancient authorities, must instead be inferred.

In the earlier period it was customary to nominate someone whom the consul considered the best available military commander. However, from 360 BC onward, the dictators were consulares. There was only one dictator at a time, although a new dictator could be appointed following the resignation of another. A dictator could be compelled to resign his office without accomplishing his task or serving out his term if there were found to be a fault in the auspices under which he had been nominated. Like other curule magistrates, the dictator was entitled to the toga praetexta and the sella curulis, he received a ceremonial bodyguard, unique in Roman tradition: "wenty-four lictors indicated his quasi-regal power, however, was rather a concentration of the consular authority than a limited revival of the kingship."In a notable exception to the Roman reluctance to reconstitute the symbols of the kings, the lictors of the dictator never removed the axes from their fasces within the pomerium. Symbolizing their power over life and death, the axes of a dictator's lictors set him apart from all other magistrates.

In an extraordinary sign of deference, the lictors of other magistrates could not bear fasces at all when appearing before the dictator. As the kings had been accustomed to appear on horseback, this right was forbidden to the

The Best Is Yet to Come

"The Best Is Yet to Come" is a 1959 song composed by Cy Coleman to lyrics by Carolyn Leigh. It is associated with Frank Sinatra, who recorded it on his 1964 album It Might as Well Be Swing accompanied by Count Basie under the direction of Quincy Jones, it was the last song Sinatra sang in public, on February 25, 1995, the words "The Best is Yet to Come" are etched on Sinatra's tombstone. Although Sinatra made it popular, the song was introduced by Tony Bennett. Tony Bennett Tony Bennett and Diana Krall Tony Bennett and Diana Krall in Tony Bennett: An American Classic. Documentary directed by Rob Marshall Michael Bublé James Darren Blossom Dearie Matt Dusk Bob Dylan Ella Fitzgerald Stacey Kent Chaka Khan Peggy Lee Diane Schuur Frank Sinatra Lisa Stansfield Nancy Wilson Sarah Vaughan In February 1999, James Darren and Avery Brooks sang the song in the final scene of "Badda-Bing Badda-Bang", a seventh-season episode of the syndicated science fiction television series Star Trek: Deep Space Nine.

The song was played as a wake-up call for the crew of Apollo 10 on May 22, 1969. The historic day marked the first time that the Lunar Module flew solo in lunar orbit as it made man's closest approach to the lunar surface to date