Diacylglycerol—sterol O-acyltransferase

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diacylglycerol-sterol O-acyltransferase
EC number2.3.1.73
CAS number79586-23-5
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a diacylglycerol-sterol O-acyltransferase (EC is an enzyme that catalyzes the chemical reaction

1,2-diacyl-sn-glycerol + sterol monoacylglycerol + sterol ester

Thus, the two substrates of this enzyme are 1,2-diacyl-sn-glycerol and sterol, whereas its two products are monoacylglycerol and sterol ester.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 1,2-diacyl-sn-glycerol:sterol O-acyltransferase. This enzyme is also called 1,2-diacyl-sn-glycerol:sterol acyl transferase. This enzyme participates in bile acid biosynthesis.


  • Bartlett K, Keat MJ, Mercer EI (1974). "Biosynthesis of sterol esters in Phycomyces blakesleeanus". Phytochemistry. 13: 1107&ndash, 1113. doi:10.1016/0031-9422(74)80083-X.
  • Garcia RE, Mudd JB (1978). "Metabolism of monoacylglycerol and diacylglycerol by enzyme preparations from spinach leaves". Arch. Biochem. Biophys. 191 (2): 487&ndash, 93. doi:10.1016/0003-9861(78)90387-9. PMID 742884.
  • Garcia RE; Mudd JB (1981). "1,2-Diacyl-sn-glycerol:sterol acyl transferase from spinach leaves (Spinacia oleracea L.)". Methods Enzymol. 71: 768&ndash, 772. doi:10.1016/0076-6879(81)71090-5.