Diacylglycerol diphosphate phosphatase

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Diacylglycerol diphosphate phosphatase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Diacylglycerol diphosphate phosphatase (EC, DGPP phosphatase, DGPP phosphohydrolase, DPP1, DPPL1, DPPL2, PAP2, pyrophosphate phosphatase) is an enzyme with systematic name 1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

1,2-diacyl-sn-glycerol 3-diphosphate + H2O 1,2-diacyl-sn-glycerol 3-phosphate + phosphate

The phosphatase activity of this enzyme is Mg2+-independent.


  1. ^ Dillon, D.A.; Wu, W.I.; Riedel, B.; Wissing, J.B.; Dowhan, W.; Carman, G.M. (1996). "The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity". J. Biol. Chem. 271: 30548–30553. doi:10.1074/jbc.271.48.30548. PMID 8940025. 
  2. ^ Dillon, D.A.; Chen, X.; Zeimetz, G.M.; Wu, W.I.; Waggoner, D.W.; Dewald, J.; Brindley, D.N.; Carman, G.M. (1997). "Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity". J. Biol. Chem. 272: 10361–10366. doi:10.1074/jbc.272.16.10361. PMID 9099673. 
  3. ^ Wu, W.I.; Liu, Y.; Riedel, B.; Wissing, J.B.; Fischl, A.S.; Carman, G.M. (1996). "Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae". J. Biol. Chem. 271: 1868–1876. doi:10.1074/jbc.271.4.1868. PMID 8567632. 
  4. ^ Oshiro, J.; Han, G.S.; Carman, G.M. (2003). "Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae". Biochim. Biophys. Acta. 1635: 1–9. doi:10.1016/j.bbalip.2003.10.002. PMID 14642771. 
  5. ^ Carman, G.M. (1997). "Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli". Biochim. Biophys. Acta. 1348: 45–55. doi:10.1016/s0005-2760(97)00095-7. PMID 9370315. 
  6. ^ Han, G.S.; Johnston, C.N.; Chen, X.; Athenstaedt, K.; Daum, G.; Carman, G.M. (2001). "Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc". J. Biol. Chem. 276: 10126–10133. doi:10.1074/jbc.m011421200. PMID 11139591. 

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