Donovan's Brain is an independently made 1953 American black-and-white science fiction horror film, produced by Tom Gries for Allan Dowling Productions, directed by Felix Feist, that stars Lew Ayres, Gene Evans, Nancy Davis and Steve Brodie. The film was distributed by United Artists and is based on the 1942 horror novel Donovan's Brain by Curt Siodmak.

Lewis Frederick Ayres III was an American actor whose film and television career spanned 65 years. He is best known for starring as German soldier Paul Bäumer in the film All Quiet on the Western Front (1930) and for playing Dr. Kildare in nine films. He was nominated for an Academy Award for Best Actor for his performance in Johnny Belinda (1948).