Estradiol stearate

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Estradiol stearate
Estradiol stearate structure.svg
Clinical data
Trade names Depofollan
Synonyms Estradiol octadecanoate
Routes of
Intramuscular injection
CAS Number
PubChem CID
Chemical and physical data
Formula C36H58O3
Molar mass 538.86 g·mol−1
3D model (JSmol)

Estradiol stearate (brand name Depofollan), or estradiol octadecanoate, is a naturally occurring steroidal estrogen and an estrogen ester – specifically, the C17β stearate ester of estradiol.[1][2][3] It occurs in the body as a very long-lasting metabolite and prohormone of estradiol.[3] In addition, estradiol stearate is or has been available as a pharmaceutical drug for use via depot intramuscular injection.[1][2] The drug was introduced in 1941 as Depofollan and was the first long-acting estrogen, although it has never been widely used.[4] It has been reported in at least one source to have a duration of at least one month.[4]

See also[edit]


  1. ^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 898. ISBN 978-1-4757-2085-3. 
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 405–. ISBN 978-3-88763-075-1. 
  3. ^ a b Hochberg RB, Pahuja SL, Larner JM, Zielinski JE (1990). "Estradiol-fatty acid esters. Endogenous long-lived estrogens". Ann. N. Y. Acad. Sci. 595: 74–92. doi:10.1111/j.1749-6632.1990.tb34284.x. PMID 2197972. 
  4. ^ a b Orvostudomány. Magyar Tudomanyos Akadémia V. Orvosi Tudományok Osztálya. 1960. p. 11.