FUT2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
FUT2
Identifiers
Aliases FUT2, B12QTL1, SE, SEC2, Se2, sej, fucosyltransferase 2
External IDs MGI: 109374 HomoloGene: 10325 GeneCards: FUT2
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for FUT2
Genomic location for FUT2
Band 19q13.33 Start 48,695,971 bp[1]
End 48,705,950 bp[1]
RNA expression pattern
PBB GE FUT2 208505 s at fs.png

PBB GE FUT2 210608 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001097638
NM_000511

NM_001271993
NM_018876

RefSeq (protein)

NP_000502
NP_001091107

NP_001258922
NP_061364

Location (UCSC) Chr 19: 48.7 – 48.71 Mb Chr 19: 45.65 – 45.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene.[5][6] It affects the Lewis blood group.[citation needed]

Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the norovirus GII.4.[citation needed]


References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176920 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055978 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. 
  6. ^ "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)". 

Further reading[edit]