FUT6

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FUT6
Identifiers
AliasesFUT6, FCT3A, FT1A, Fuc-TVI, FucT-VI, fucosyltransferase 6
External IDsHomoloGene: 34780 GeneCards: FUT6
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for FUT6
Genomic location for FUT6
Band19p13.3Start5,830,610 bp[1]
End5,839,731 bp[1]
RNA expression pattern
PBB GE FUT6 211465 x at fs.png

PBB GE FUT6 210399 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000150
NM_001040701

n/a

RefSeq (protein)

NP_000141
NP_001035791

n/a

Location (UCSC)Chr 19: 5.83 – 5.84 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.[3][4][5]

The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM][5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156413 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Koszdin KL, Bowen BR (Oct 1992). "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand". Biochem Biophys Res Commun. 187 (1): 152–7. doi:10.1016/S0006-291X(05)81472-X. PMID 1520296. 
  4. ^ McCurley RS, Recinos A III, Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW (Jul 1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21". Genomics. 26 (1): 142–6. doi:10.1016/0888-7543(95)80094-3. PMID 7782074. 
  5. ^ a b "Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)". 

Further reading[edit]