Simplified molecular-input line-entry system
The simplified molecular-input line-entry system is a specification in the form of a line notation for describing the structure of chemical species using short ASCII strings. SMILES strings can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the molecules; the original SMILES specification was initiated in the 1980s. It has since been extended. In 2007, an open standard called. Other linear notations include the Wiswesser line notation, ROSDAL, SYBYL Line Notation; the original SMILES specification was initiated by David Weininger at the USEPA Mid-Continent Ecology Division Laboratory in Duluth in the 1980s. Acknowledged for their parts in the early development were "Gilman Veith and Rose Russo and Albert Leo and Corwin Hansch for supporting the work, Arthur Weininger and Jeremy Scofield for assistance in programming the system." The Environmental Protection Agency funded the initial project to develop SMILES. It has since been modified and extended by others, most notably by Daylight Chemical Information Systems.
In 2007, an open standard called "OpenSMILES" was developed by the Blue Obelisk open-source chemistry community. Other'linear' notations include the Wiswesser Line Notation, ROSDAL and SLN. In July 2006, the IUPAC introduced the InChI as a standard for formula representation. SMILES is considered to have the advantage of being more human-readable than InChI; the term SMILES refers to a line notation for encoding molecular structures and specific instances should be called SMILES strings. However, the term SMILES is commonly used to refer to both a single SMILES string and a number of SMILES strings; the terms "canonical" and "isomeric" can lead to some confusion when applied to SMILES. The terms are not mutually exclusive. A number of valid SMILES strings can be written for a molecule. For example, CCO, OCC and CC all specify the structure of ethanol. Algorithms have been developed to generate the same SMILES string for a given molecule; this SMILES is unique for each structure, although dependent on the canonicalization algorithm used to generate it, is termed the canonical SMILES.
These algorithms first convert the SMILES to an internal representation of the molecular structure. Various algorithms for generating canonical SMILES have been developed and include those by Daylight Chemical Information Systems, OpenEye Scientific Software, MEDIT, Chemical Computing Group, MolSoft LLC, the Chemistry Development Kit. A common application of canonical SMILES is indexing and ensuring uniqueness of molecules in a database; the original paper that described the CANGEN algorithm claimed to generate unique SMILES strings for graphs representing molecules, but the algorithm fails for a number of simple cases and cannot be considered a correct method for representing a graph canonically. There is no systematic comparison across commercial software to test if such flaws exist in those packages. SMILES notation allows the specification of configuration at tetrahedral centers, double bond geometry; these are structural features that cannot be specified by connectivity alone and SMILES which encode this information are termed isomeric SMILES.
A notable feature of these rules is. The term isomeric SMILES is applied to SMILES in which isotopes are specified. In terms of a graph-based computational procedure, SMILES is a string obtained by printing the symbol nodes encountered in a depth-first tree traversal of a chemical graph; the chemical graph is first trimmed to remove hydrogen atoms and cycles are broken to turn it into a spanning tree. Where cycles have been broken, numeric suffix labels are included to indicate the connected nodes. Parentheses are used to indicate points of branching on the tree; the resultant SMILES form depends on the choices: of the bonds chosen to break cycles, of the starting atom used for the depth-first traversal, of the order in which branches are listed when encountered. Atoms are represented by the standard abbreviation of the chemical elements, in square brackets, such as for gold. Brackets may be omitted in the common case of atoms which: are in the "organic subset" of B, C, N, O, P, S, F, Cl, Br, or I, have no formal charge, have the number of hydrogens attached implied by the SMILES valence model, are the normal isotopes, are not chiral centers.
All other elements must be enclosed in brackets, have charges and hydrogens shown explicitly. For instance, the SMILES for water may be written as either O or. Hydrogen may be written as a separate atom; when brackets are used, the symbol H is added if the atom in brackets is bonded to one or more hydrogen, followed by the number of hydrogen atoms if greater than 1 by the sign + for a positive charge or by - for a negative charge. For example, for ammonium. If there is more than one charge, it is written as digit.
Romania is a country located at the crossroads of Central and Southeastern Europe. It borders the Black Sea to the southeast, Bulgaria to the south, Ukraine to the north, Hungary to the west, Serbia to the southwest, Moldova to the east, it has a predominantly temperate-continental climate. With a total area of 238,397 square kilometres, Romania is the 12th largest country and the 7th most populous member state of the European Union, having 20 million inhabitants, its capital and largest city is Bucharest, other major urban areas include Cluj-Napoca, Timișoara, Iași, Constanța, Brașov. The River Danube, Europe's second-longest river, rises in Germany's Black Forest and flows in a general southeast direction for 2,857 km, coursing through ten countries before emptying into Romania's Danube Delta; the Carpathian Mountains, which cross Romania from the north to the southwest, include Moldoveanu Peak, at an altitude of 2,544 m. Modern Romania was formed in 1859 through a personal union of the Danubian Principalities of Moldavia and Wallachia.
The new state named Romania since 1866, gained independence from the Ottoman Empire in 1877. Following World War I, when Romania fought on the side of the Allied powers, Bessarabia, Transylvania as well as parts of Banat, Crișana, Maramureș became part of the sovereign Kingdom of Romania. In June–August 1940, as a consequence of the Molotov–Ribbentrop Pact and Second Vienna Award, Romania was compelled to cede Bessarabia and Northern Bukovina to the Soviet Union, Northern Transylvania to Hungary. In November 1940, Romania signed the Tripartite Pact and in June 1941 entered World War II on the Axis side, fighting against the Soviet Union until August 1944, when it joined the Allies and recovered Northern Transylvania. Following the war, under the occupation of the Red Army's forces, Romania became a socialist republic and member of the Warsaw Pact. After the 1989 Revolution, Romania began a transition back towards a market economy; the sovereign state of Romania is a developing country and ranks 52nd in the Human Development Index.
It has the world's 47th largest economy by nominal GDP and an annual economic growth rate of 7%, the highest in the EU at the time. Following rapid economic growth in the early 2000s, Romania has an economy predominantly based on services, is a producer and net exporter of machines and electric energy, featuring companies like Automobile Dacia and OMV Petrom, it has been a member of the United Nations since 1955, part of NATO since 2004, part of the European Union since 2007. An overwhelming majority of the population identifies themselves as Eastern Orthodox Christians and are native speakers of Romanian, a Romance language. Romania derives from the Latin romanus, meaning "citizen of Rome"; the first known use of the appellation was attested to in the 16th century by Italian humanists travelling in Transylvania and Wallachia. The oldest known surviving document written in Romanian, a 1521 letter known as the "Letter of Neacșu from Câmpulung", is notable for including the first documented occurrence of the country's name: Wallachia is mentioned as Țeara Rumânească.
Two spelling forms: român and rumân were used interchangeably until sociolinguistic developments in the late 17th century led to semantic differentiation of the two forms: rumân came to mean "bondsman", while român retained the original ethnolinguistic meaning. After the abolition of serfdom in 1746, the word rumân fell out of use and the spelling stabilised to the form român. Tudor Vladimirescu, a revolutionary leader of the early 19th century, used the term Rumânia to refer to the principality of Wallachia."The use of the name Romania to refer to the common homeland of all Romanians—its modern-day meaning—was first documented in the early 19th century. The name has been in use since 11 December 1861. In English, the name of the country was spelt Rumania or Roumania. Romania became the predominant spelling around 1975. Romania is the official English-language spelling used by the Romanian government. A handful of other languages have switched to "o" like English, but most languages continue to prefer forms with u, e.g. French Roumanie and Swedish Rumänien, Spanish Rumania, Polish Rumunia, Russian Румыния, Japanese ルーマニア.
1859–1862: United Principalities of Moldavia and Wallachia 1862–1866: Romanian United Principalities or Romania 1866–1881: Romania or Principality of Romania 1881–1947: Kingdom of Romania or Romania 1947–1965: Romanian People's Republic or Romania 1965–December, 1989: Socialist Republic of Romania or Romania December, 1989–present: Romania Human remains found in Peștera cu Oase, radiocarbon dated as being from circa 40,000 years ago, represent the oldest known Homo sapiens in Europe. Neolithic techniques and agriculture spread after the arrival of a mixed group of people from Thessaly in the 6th millenium BC. Excavations near a salt spring at Lunca yielded the earliest evidence for salt exploitation in Europe; the first permanent settlements appeared in the Neolithic. Some of them developed into "proto-cities"; the Cucuteni–Trypillia culture—the best known archaeological culture of Old Europe—flourished in Muntenia, southeastern Transylvania and northeastern Moldavia in the 3rd m
Otorhinolaryngology is a surgical subspecialty within medicine that deals with conditions of the ear and throat and related structures of the head and neck. Doctors who specialize in this area are called otorhinolaryngologists, otolaryngologists, ENT doctors, ENT surgeons, or head and neck surgeons. Patients seek treatment from an otorhinolaryngologist for diseases of the ear, throat, base of the skull, for the surgical management of cancers and benign tumors of the head and neck; the term is a combination of New Latin combining forms derived from four Ancient Greek words: οὖς ous, "ear", ῥίς rhis, "nose", λάρυγξ larynx, "larynx" and -λογία logia, "study". Otorhinolaryngologists are physicians who, in the United States, complete at least five years of surgical residency training; this is composed of six months of general surgical training and four and a half years in specialist surgery. In Canada and the United States, practitioners complete a five-year residency training after medical school.
Following residency training, some otolaryngologist-head & neck surgeons complete an advanced sub-specialty fellowship, where training can be one to two years in duration. In the United States and Canada, otorhinolaryngology is one of the most competitive specialties in medicine in which to obtain a residency position following medical school. In the United Kingdom entrance to otorhinolaryngology higher surgical training is competitive and involves a rigorous national selection process; the training programme consists of 6 years of higher surgical training after which trainees undertake fellowships in a sub-speciality prior to becoming a consultant. In this type of surgery, a surgeon harvests a muscle from the back or from the abdominal region for reconstruction of the skull or the cranial vault. Latissimus is another word for back in the medical field as well as rectus abdominis, your abdominal area; the muscle is sometimes useful for sealing off the central nervous system in ones body and allowing it to heal the complex wounds.
A study was down with five patients who underwent the free muscle transfer for a smile reconstruction. Two of the five patients prior to this surgery had failed their first free muscle transfer; the next two patients had vascular anomalies and one had a previous distal ligation of the facial vessels. In three of the cases, they used a submental vein, in all the cases they used a donor submental artery. “In all 5 the gracilis vascular pedicle comprised a muscular branch of the profunda femoris together with its venae comitantes, with the artery and vein ranging in size from 1.0 to 1.5 mm and 2.0 to 2.5 mm, respectively. The submental artery provided an excellent size match in all cases, ranging in size from 1.0 to 1.5 mm”. The first patient was a 45 year old woman who developed a dense flaccid right facial paralysis at the age of 33; the second patient was an 8 year old girl who had developed dense flaccid left facial paralysis after a laser treatment at four weeks for, “bilateral infantile segmental hemangiomas in the distribution of the mandibular division of the trigeminal nerve.
“. The third case was a 19 year old male who had developed a segmental right facial paralysis after a excision of a infantile parotid hemangioma at the age of 2; the fourth case was a 20 year old woman who had developed dense flaccid right facial paralysis after a biopsy of a pontomedullary junction tumor at the age of 2. Lastly, case five was a 19 year old woman. Bone defects are the most difficult reconstructions as it requires precise alignment. Bone transfer is used for the mandibular reconstruction, but it now allows surgeons to use it for the midface and the orbito maxillary. If for some reason the fibula is not available for transfer, another option the team may go is using the back rib free flap; this allows the transfer to give the bone volume for the patients. The earliest first bone transfer was done all the way back in 2000 BCE when the Peruvian priest implanted a metallic plate to reconstruct the contour defects of the religious trephination. In 1668, a man by the name of Jobs van Meekeren reported the use of dog bone grafts to reconstruct the calvarium in the soldier.
“…the ideal of the future: the insertion of a piece of living bone which will fill the gap and will continue to live without absorption.”. The radial forearm is the most dominant use of flap to be used to coverage up damages. Today, the anterolateral thigh flap is being used on patients for the head and the neck because it has an ideal match for the site and it is easy to harvest. If a surgeon chose to remove/harvest the tissue, safe places are the following. Microvascular reconstruction repair is a common operation, done on patients who see a Otorhinolaryngologist. Microvascular reconstruction repair is a surgical procedure that involves moving a composite piece of tissue from the patient's body and moves it to the head and or neck. Microvascular head and neck reconstruction is used to treat head and neck cancers, including those of the larynx and pharynx, oral cavity, salivary glands, calvarium, sinuses and skin; the tissue, most common moved during this procedure is from the arms, legs and can come from the skin, fat, or muscle.
When doing this procedure, the decision on, moved is determined on the reconstructive needs. T
Russia the Russian Federation, is a transcontinental country in Eastern Europe and North Asia. At 17,125,200 square kilometres, Russia is by far or by a considerable margin the largest country in the world by area, covering more than one-eighth of the Earth's inhabited land area, the ninth most populous, with about 146.77 million people as of 2019, including Crimea. About 77 % of the population live in the European part of the country. Russia's capital, Moscow, is one of the largest cities in the world and the second largest city in Europe. Extending across the entirety of Northern Asia and much of Eastern Europe, Russia spans eleven time zones and incorporates a wide range of environments and landforms. From northwest to southeast, Russia shares land borders with Norway, Estonia, Latvia and Poland, Ukraine, Azerbaijan, China and North Korea, it shares maritime borders with Japan by the Sea of Okhotsk and the U. S. state of Alaska across the Bering Strait. However, Russia recognises two more countries that border it, Abkhazia and South Ossetia, both of which are internationally recognized as parts of Georgia.
The East Slavs emerged as a recognizable group in Europe between the 3rd and 8th centuries AD. Founded and ruled by a Varangian warrior elite and their descendants, the medieval state of Rus arose in the 9th century. In 988 it adopted Orthodox Christianity from the Byzantine Empire, beginning the synthesis of Byzantine and Slavic cultures that defined Russian culture for the next millennium. Rus' disintegrated into a number of smaller states; the Grand Duchy of Moscow reunified the surrounding Russian principalities and achieved independence from the Golden Horde. By the 18th century, the nation had expanded through conquest and exploration to become the Russian Empire, the third largest empire in history, stretching from Poland on the west to Alaska on the east. Following the Russian Revolution, the Russian Soviet Federative Socialist Republic became the largest and leading constituent of the Union of Soviet Socialist Republics, the world's first constitutionally socialist state; the Soviet Union played a decisive role in the Allied victory in World War II, emerged as a recognized superpower and rival to the United States during the Cold War.
The Soviet era saw some of the most significant technological achievements of the 20th century, including the world's first human-made satellite and the launching of the first humans in space. By the end of 1990, the Soviet Union had the world's second largest economy, largest standing military in the world and the largest stockpile of weapons of mass destruction. Following the dissolution of the Soviet Union in 1991, twelve independent republics emerged from the USSR: Russia, Belarus, Uzbekistan, Azerbaijan, Kyrgyzstan, Tajikistan and the Baltic states regained independence: Estonia, Lithuania, it is governed as a federal semi-presidential republic. Russia's economy ranks as the twelfth largest by nominal GDP and sixth largest by purchasing power parity in 2018. Russia's extensive mineral and energy resources are the largest such reserves in the world, making it one of the leading producers of oil and natural gas globally; the country is one of the five recognized nuclear weapons states and possesses the largest stockpile of weapons of mass destruction.
Russia is a great power as well as a regional power and has been characterised as a potential superpower. It is a permanent member of the United Nations Security Council and an active global partner of ASEAN, as well as a member of the Shanghai Cooperation Organisation, the G20, the Council of Europe, the Asia-Pacific Economic Cooperation, the Organization for Security and Co-operation in Europe, the World Trade Organization, as well as being the leading member of the Commonwealth of Independent States, the Collective Security Treaty Organization and one of the five members of the Eurasian Economic Union, along with Armenia, Belarus and Kyrgyzstan; the name Russia is derived from Rus', a medieval state populated by the East Slavs. However, this proper name became more prominent in the history, the country was called by its inhabitants "Русская Земля", which can be translated as "Russian Land" or "Land of Rus'". In order to distinguish this state from other states derived from it, it is denoted as Kievan Rus' by modern historiography.
The name Rus itself comes from the early medieval Rus' people, Swedish merchants and warriors who relocated from across the Baltic Sea and founded a state centered on Novgorod that became Kievan Rus. An old Latin version of the name Rus' was Ruthenia applied to the western and southern regions of Rus' that were adjacent to Catholic Europe; the current name of the country, Россия, comes from the Byzantine Greek designation of the Rus', Ρωσσία Rossía—spelled Ρωσία in Modern Greek. The standard way to refer to citizens of Russia is rossiyane in Russian. There are two Russian words which are commonly
Formoterol known as eformoterol, is a long-acting β2 agonist used as a bronchodilator in the management of asthma and COPD. Formoterol has an extended duration of action compared to short-acting β2 agonists such as salbutamol, which are effective for 4 h to 6 h. LABAs such as formoterol are used as "symptom controllers" to supplement prophylactic corticosteroid therapy. A "reliever" short-acting β2 agonist is still required, since LABAs are not recommended for the treatment of acute asthma, it was patented in 1972 and came into medical use in 1998. It is marketed in the combination formulations budesonide/formoterol and mometasone/formoterol. In November 2005, the US FDA released a health advisory alerting the public to findings that show the use of long-acting β2 agonists could lead to a worsening of wheezing symptoms in some patients. At the current time, available long-acting β2 agonists include salmeterol, formoterol and sustained-release oral salbutamol. Combinations of inhaled steroids and long-acting bronchodilators are becoming more widespread – combination preparations include fluticasone/salmeterol and budesonide/formoterol.
Inhaled formoterol works like other β2 agonists, causing bronchodilation by relaxing the smooth muscle in the airway so as to treat the exacerbation of asthma. It is marketed in three forms: a dry-powder inhaler, a metered-dose inhaler and an inhalation solution, under various trade names including Atock, Atimos/Atimos Modulite, Foradil/Foradile, Oxeze/Oxis, Perforomist. Foradil/Foradile capsules for oral inhalation Oxeze/Oxis Turbuhaler DPI Atock Atimos/Atimos Modulite MDI Perforomist inhalation solution Arformoterol — an enantiopure compound used in the management of COPD Combination drugs: Aclidinium bromide/formoterol Budesonide/formoterol Mometasone furoate/formoterol
Sympathomimetic drugs are stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system. The primary endogenous agonists of the sympathetic nervous system are the catecholamines, which function as both neurotransmitters and hormones. Sympathomimetic drugs are used to treat cardiac arrest and low blood pressure, or delay premature labor, among other things; these drugs can act through several mechanisms, such as directly activating postsynaptic receptors, blocking breakdown and reuptake of certain neurotransmitters, or stimulating production and release of catecholamines. The mechanisms of sympathomimetic drugs can be direct-acting, such as α-adrenergic agonists, β-adrenergic agonists, dopaminergic agonists. For maximum sympathomimetic activity, a drug must have: Amine group two carbons away from an aromatic group A hydroxyl group at the chiral beta position in the R-configuration Hydroxyl groups in the meta and para position of the aromatic ring to form a catechol, essential for receptor bindingThe structure can be modified to alter binding.
If the amine is primary or secondary, it will have direct action, but if the amine is tertiary, it will have poor direct action. If the amine has bulky substituents it will have greater beta adrenergic receptor activity, but if the substituent is not bulky it will favor the alpha adrenergic receptors. Direct stimulation of the α- and β-adrenergic receptors can produce sympathomimetic effects. Salbutamol is a used direct-acting β2-agonist. Other examples include phenylephrine and dobutamine. Stimulation of the D1 receptor by dopaminergic agonists such as fenoldopam is used intravenously to treat hypertensive crisis. Dopaminergic stimulants such as amphetamine and propylhexedrine work by causing the release of dopamine and norepinephrine, along with blocking the reuptake of these neurotransmitters. A primary or secondary aliphatic amine separated by 2 carbons from a substituted benzene ring is minimally required for high agonist activity; the pKa of the amine is 8.5-10. The presence of hydroxy group in the benzene ring at 3rd and 4th position shows maximum alpha- and beta-adrenergic activity.
Substances such as cocaine affect dopamine, some substances such as MDMA affect serotonin. Norepinephrine is synthesized by the body from the amino acid tyrosine, is used in the synthesis of epinephrine, a stimulating neurotransmitter of the central nervous system. Thus, all sympathomimetic amines fall into the larger group of stimulants. In addition to intended therapeutic use, many of these stimulants have abuse potential, can induce tolerance, physical dependence, although not by the same mechanism as opioids or sedatives; the symptoms of physical withdrawal from stimulants can include fatigue, dysphoric mood, increased appetite, vivid or lucid dreams, hypersomnia or insomnia, increased movement or decreased movement and drug craving, as is apparent in the rebound withdrawal from certain substituted amphetamines. Physical withdrawal from some sedatives can be lethal, for instance benzodiazepine withdrawal syndrome. Opioid withdrawal is uncomfortable described as a bad case of the flu, with severe abdominal cramps and diarrhoea as central symptoms, but it is lethal unless the user has a comorbid condition.
"Parasympatholytic" and "sympathomimetic" have similar effects, but through different pathways. For example, both cause mydriasis, but parasympatholytics reduce accommodation while sympathomimetics do not. Amphetamine benzylpiperazine cathine cathinone cocaine ephedrine lisdexamfetamine maprotiline MDMA methamphetamine methcathinone methylenedioxypyrovalerone methylphenidate 4-methylaminorex oxymetazoline pemoline phenmetrazine propylhexedrine pseudoephedrine Sympathetic nervous system Sympatholytic Amines,+Sympathomimetic at the US National Library of Medicine Medical Subject Headings
Excretion is a process by which metabolic waste is eliminated from an organism. In vertebrates this is carried out by the lungs and skin; this is in contrast with secretion, where the substance may have specific tasks after leaving the cell. Excretion is an essential process in all forms of life. For example, in mammals urine is expelled through the urethra, part of the excretory system. In unicellular organisms, waste products are discharged directly through the surface of the cell. During life activities such as cellular respiration, several chemical reactions take place in the body; these are known as metabolism. These chemical reactions produce waste products such as carbon dioxide, salts and uric acid. Accumulation of these wastes beyond a level inside the body is harmful to the body; the excretory organs remove these wastes. This process of removal of metabolic waste from the body is known as excretion. Green plants produce carbon water as respiratory products. In green plants, the carbon dioxide released during respiration gets utilized during photosynthesis.
Oxygen is a by product generated during photosynthesis, exits through stomata, root cell walls, other routes. Plants can get rid of excess water by guttation, it has been shown that the leaf acts as an'excretophore' and, in addition to being a primary organ of photosynthesis, is used as a method of excreting toxic wastes via diffusion. Other waste materials that are exuded by some plants — resin, latex, etc. are forced from the interior of the plant by hydrostatic pressures inside the plant and by absorptive forces of plant cells. These latter processes do not need added energy, they act passively. However, during the pre-abscission phase, the metabolic levels of a leaf are high. Plants excrete some waste substances into the soil around them. In animals, the main excretory products are carbon dioxide, urea, uric acid and creatine; the liver and kidneys clear many substances from the blood, the cleared substances are excreted from the body in the urine and feces. Aquatic animals excrete ammonia directly into the external environment, as this compound has high solubility and there is ample water available for dilution.
In terrestrial animals ammonia-like compounds are converted into other nitrogenous materials as there is less water in the environment and ammonia itself is toxic. Birds excrete their nitrogenous wastes as uric acid in the form of a paste. Although this process is metabolically more expensive, it allows more efficient water retention and it can be stored more in the egg. Many avian species seabirds, can excrete salt via specialized nasal salt glands, the saline solution leaving through nostrils in the beak. In insects, a system involving Malpighian tubules is utilized to excrete metabolic waste. Metabolic waste diffuses or is transported into the tubule, which transports the wastes to the intestines; the metabolic waste is released from the body along with fecal matter. The excreted material may be called ejecta. In pathology the word ejecta is more used. UAlberta.ca, Animation of excretion Brian J Ford on leaf fall in Nature