1.
Jmol
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Jmol is computer software for molecular modelling chemical structures in 3-dimensions. Jmol returns a 3D representation of a molecule that may be used as a teaching tool and it is written in the programming language Java, so it can run on the operating systems Windows, macOS, Linux, and Unix, if Java is installed. It is free and open-source software released under a GNU Lesser General Public License version 2.0, a standalone application and a software development kit exist that can be integrated into other Java applications, such as Bioclipse and Taverna. A popular feature is an applet that can be integrated into web pages to display molecules in a variety of ways, for example, molecules can be displayed as ball-and-stick models, space-filling models, ribbon diagrams, etc. Jmol supports a range of chemical file formats, including Protein Data Bank, Crystallographic Information File, MDL Molfile. There is also a JavaScript-only version, JSmol, that can be used on computers with no Java, the Jmol applet, among other abilities, offers an alternative to the Chime plug-in, which is no longer under active development. While Jmol has many features that Chime lacks, it does not claim to reproduce all Chime functions, most notably, Chime requires plug-in installation and Internet Explorer 6.0 or Firefox 2.0 on Microsoft Windows, or Netscape Communicator 4.8 on Mac OS9. Jmol requires Java installation and operates on a variety of platforms. For example, Jmol is fully functional in Mozilla Firefox, Internet Explorer, Opera, Google Chrome, fast and Scriptable Molecular Graphics in Web Browsers without Java3D
2.
ChEMBL
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ChEMBL or ChEMBLdb is a manually curated chemical database of bioactive molecules with drug-like properties. It is maintained by the European Bioinformatics Institute, of the European Molecular Biology Laboratory, based at the Wellcome Trust Genome Campus, Hinxton, the database, originally known as StARlite, was developed by a biotechnology company called Inpharmatica Ltd. later acquired by Galapagos NV. The data was acquired for EMBL in 2008 with an award from The Wellcome Trust, resulting in the creation of the ChEMBL chemogenomics group at EMBL-EBI, the ChEMBL database contains compound bioactivity data against drug targets. Bioactivity is reported in Ki, Kd, IC50, and EC50, data can be filtered and analyzed to develop compound screening libraries for lead identification during drug discovery. ChEMBL version 2 was launched in January 2010, including 2.4 million bioassay measurements covering 622,824 compounds and this was obtained from curating over 34,000 publications across twelve medicinal chemistry journals. ChEMBLs coverage of available bioactivity data has grown to become the most comprehensive ever seen in a public database, in October 2010 ChEMBL version 8 was launched, with over 2.97 million bioassay measurements covering 636,269 compounds. ChEMBL_10 saw the addition of the PubChem confirmatory assays, in order to integrate data that is comparable to the type, ChEMBLdb can be accessed via a web interface or downloaded by File Transfer Protocol. It is formatted in a manner amenable to computerized data mining, ChEMBL is also integrated into other large-scale chemistry resources, including PubChem and the ChemSpider system of the Royal Society of Chemistry. In addition to the database, the ChEMBL group have developed tools and these include Kinase SARfari, an integrated chemogenomics workbench focussed on kinases. The system incorporates and links sequence, structure, compounds and screening data, the primary purpose of ChEMBL-NTD is to provide a freely accessible and permanent archive and distribution centre for deposited data. July 2012 saw the release of a new data service, sponsored by the Medicines for Malaria Venture. The data in this service includes compounds from the Malaria Box screening set, myChEMBL, the ChEMBL virtual machine, was released in October 2013 to allow users to access a complete and free, easy-to-install cheminformatics infrastructure. In December 2013, the operations of the SureChem patent informatics database were transferred to EMBL-EBI, in a portmanteau, SureChem was renamed SureChEMBL. 2014 saw the introduction of the new resource ADME SARfari - a tool for predicting and comparing cross-species ADME targets
3.
ChemSpider
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ChemSpider is a database of chemicals. ChemSpider is owned by the Royal Society of Chemistry, the database contains information on more than 50 million molecules from over 500 data sources including, Each chemical is given a unique identifier, which forms part of a corresponding URL. This is an approach to develop an online chemistry database. The search can be used to widen or restrict already found results, structure searching on mobile devices can be done using free apps for iOS and for the Android. The ChemSpider database has been used in combination with text mining as the basis of document markup. The result is a system between chemistry documents and information look-up via ChemSpider into over 150 data sources. ChemSpider was acquired by the Royal Society of Chemistry in May,2009, prior to the acquisition by RSC, ChemSpider was controlled by a private corporation, ChemZoo Inc. The system was first launched in March 2007 in a release form. ChemSpider has expanded the generic support of a database to include support of the Wikipedia chemical structure collection via their WiChempedia implementation. A number of services are available online. SyntheticPages is an interactive database of synthetic chemistry procedures operated by the Royal Society of Chemistry. Users submit synthetic procedures which they have conducted themselves for publication on the site and these procedures may be original works, but they are more often based on literature reactions. Citations to the published procedure are made where appropriate. They are checked by an editor before posting. The pages do not undergo formal peer-review like a journal article. The comments are moderated by scientific editors. The intention is to collect practical experience of how to conduct useful chemical synthesis in the lab, while experimental methods published in an ordinary academic journal are listed formally and concisely, the procedures in ChemSpider SyntheticPages are given with more practical detail. Comments by submitters are included as well, other publications with comparable amounts of detail include Organic Syntheses and Inorganic Syntheses
4.
DrugBank
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The DrugBank database is a comprehensive, freely accessible, online database containing information on drugs and drug targets. As both a bioinformatics and a resource, DrugBank combines detailed drug data with comprehensive drug target information. Because of its scope, comprehensive referencing and unusually detailed data descriptions. As a result, links to DrugBank are maintained for nearly all drugs listed in Wikipedia, DrugBank is widely used by the drug industry, medicinal chemists, pharmacists, physicians, students and the general public. Its extensive drug and drug-target data has enabled the discovery and repurposing of a number of existing drugs to treat rare, the latest release of the database contains 8227 drug entries including 2003 FDA-approved small molecule drugs,221 FDA-approved biotech drugs,93 nutraceuticals and over 6000 experimental drugs. Additionally,4270 non-redundant protein sequences are linked to these drug entries, each DrugCard entry contains more than 200 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data. Four additional databases, HMDB, T3DB, SMPDB and FooDB are also part of a suite of metabolomic/cheminformatic databases. The first version of DrugBank was released in 2006 and this early release contained relatively modest information about 841 FDA-approved small molecule drugs and 113 biotech drugs. It also included information on 2133 drug targets, the second version of DrugBank was released in 2009. This greatly expanded and improved version of the database included 1344 approved small molecule drugs and 123 biotech drugs as well as 3037 unique drug targets. Version 2.0 also included, for the first time, withdrawn drugs and illicit drugs, version 3.0 was released in 2011. This version contained 1424 approved small molecule drugs and 132 biotech drugs as well as >4000 unique drug targets, version 3.0 also included drug transporter data, drug pathway data, drug pricing, patent and manufacturing data as well as data on >5000 experimental drugs. Version 4.0 was released in 2014 and this version included 1558 FDA-approved small molecule drugs,155 biotech drugs and 4200 unique drug targets. Version 4.0 also incorporated information on drug metabolites, drug taxonomy, drug spectra, drug binding constants. Table 1 provides a complete statistical summary of the history of DrugBank’s development. All data in DrugBank is non-proprietary or is derived from a non-proprietary source and it is freely accessible and available to anyone. In addition, nearly every item is fully traceable and explicitly referenced to the original source. DrugBank data is available through a web interface and downloads
5.
European Chemicals Agency
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ECHA is the driving force among regulatory authorities in implementing the EUs chemicals legislation. ECHA helps companies to comply with the legislation, advances the safe use of chemicals, provides information on chemicals and it is located in Helsinki, Finland. The Agency, headed by Executive Director Geert Dancet, started working on 1 June 2007, the REACH Regulation requires companies to provide information on the hazards, risks and safe use of chemical substances that they manufacture or import. Companies register this information with ECHA and it is freely available on their website. So far, thousands of the most hazardous and the most commonly used substances have been registered, the information is technical but gives detail on the impact of each chemical on people and the environment. This also gives European consumers the right to ask whether the goods they buy contain dangerous substances. The Classification, Labelling and Packaging Regulation introduces a globally harmonised system for classifying and labelling chemicals into the EU. This worldwide system makes it easier for workers and consumers to know the effects of chemicals, companies need to notify ECHA of the classification and labelling of their chemicals. So far, ECHA has received over 5 million notifications for more than 100000 substances, the information is freely available on their website. Consumers can check chemicals in the products they use, Biocidal products include, for example, insect repellents and disinfectants used in hospitals. The Biocidal Products Regulation ensures that there is information about these products so that consumers can use them safely. ECHA is responsible for implementing the regulation, the law on Prior Informed Consent sets guidelines for the export and import of hazardous chemicals. Through this mechanism, countries due to hazardous chemicals are informed in advance and have the possibility of rejecting their import. Substances that may have effects on human health and the environment are identified as Substances of Very High Concern 1. These are mainly substances which cause cancer, mutation or are toxic to reproduction as well as substances which persist in the body or the environment, other substances considered as SVHCs include, for example, endocrine disrupting chemicals. Companies manufacturing or importing articles containing these substances in a concentration above 0 and they are required to inform users about the presence of the substance and therefore how to use it safely. Consumers have the right to ask the retailer whether these substances are present in the products they buy, once a substance has been officially identified in the EU as being of very high concern, it will be added to a list. This list is available on ECHA’s website and shows consumers and industry which chemicals are identified as SVHCs, Substances placed on the Candidate List can then move to another list
6.
PubChem
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PubChem is a database of chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information, a component of the National Library of Medicine, PubChem can be accessed for free through a web user interface. Millions of compound structures and descriptive datasets can be downloaded via FTP. PubChem contains substance descriptions and small molecules with fewer than 1000 atoms and 1000 bonds, more than 80 database vendors contribute to the growing PubChem database. PubChem consists of three dynamically growing primary databases, as of 28 January 2016, Compounds,82.6 million entries, contains pure and characterized chemical compounds. Substances,198 million entries, contains also mixtures, extracts, complexes, bioAssay, bioactivity results from 1.1 million high-throughput screening programs with several million values. PubChem contains its own online molecule editor with SMILES/SMARTS and InChI support that allows the import and export of all common chemical file formats to search for structures and fragments. In the text search form the database fields can be searched by adding the name in square brackets to the search term. A numeric range is represented by two separated by a colon. The search terms and field names are case-insensitive, parentheses and the logical operators AND, OR, and NOT can be used. AND is assumed if no operator is used, example,0,5000,50,10 -5,5 PubChem was released in 2004. The American Chemical Society has raised concerns about the publicly supported PubChem database and they have a strong interest in the issue since the Chemical Abstracts Service generates a large percentage of the societys revenue. To advocate their position against the PubChem database, ACS has actively lobbied the US Congress, soon after PubChems creation, the American Chemical Society lobbied U. S. Congress to restrict the operation of PubChem, which they asserted competes with their Chemical Abstracts Service
7.
International Chemical Identifier
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Initially developed by IUPAC and NIST from 2000 to 2005, the format and algorithms are non-proprietary. The continuing development of the standard has supported since 2010 by the not-for-profit InChI Trust. The current version is 1.04 and was released in September 2011, prior to 1.04, the software was freely available under the open source LGPL license, but it now uses a custom license called IUPAC-InChI Trust License. Not all layers have to be provided, for instance, the layer can be omitted if that type of information is not relevant to the particular application. InChIs can thus be seen as akin to a general and extremely formalized version of IUPAC names and they can express more information than the simpler SMILES notation and differ in that every structure has a unique InChI string, which is important in database applications. Information about the 3-dimensional coordinates of atoms is not represented in InChI, the InChI algorithm converts input structural information into a unique InChI identifier in a three-step process, normalization, canonicalization, and serialization. The InChIKey, sometimes referred to as a hashed InChI, is a fixed length condensed digital representation of the InChI that is not human-understandable. The InChIKey specification was released in September 2007 in order to facilitate web searches for chemical compounds and it should be noted that, unlike the InChI, the InChIKey is not unique, though collisions can be calculated to be very rare, they happen. In January 2009 the final 1.02 version of the InChI software was released and this provided a means to generate so called standard InChI, which does not allow for user selectable options in dealing with the stereochemistry and tautomeric layers of the InChI string. The standard InChIKey is then the hashed version of the standard InChI string, the standard InChI will simplify comparison of InChI strings and keys generated by different groups, and subsequently accessed via diverse sources such as databases and web resources. Every InChI starts with the string InChI= followed by the version number and this is followed by the letter S for standard InChIs. The remaining information is structured as a sequence of layers and sub-layers, the layers and sub-layers are separated by the delimiter / and start with a characteristic prefix letter. The six layers with important sublayers are, Main layer Chemical formula and this is the only sublayer that must occur in every InChI. The atoms in the formula are numbered in sequence, this sublayer describes which atoms are connected by bonds to which other ones. Describes how many hydrogen atoms are connected to each of the other atoms, the condensed,27 character standard InChIKey is a hashed version of the full standard InChI, designed to allow for easy web searches of chemical compounds. Most chemical structures on the Web up to 2007 have been represented as GIF files, the full InChI turned out to be too lengthy for easy searching, and therefore the InChIKey was developed. With all databases currently having below 50 million structures, such duplication appears unlikely at present, a recent study more extensively studies the collision rate finding that the experimental collision rate is in agreement with the theoretical expectations. Example, Morphine has the structure shown on the right, as the InChI cannot be reconstructed from the InChIKey, an InChIKey always needs to be linked to the original InChI to get back to the original structure
8.
Simplified molecular-input line-entry system
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The simplified molecular-input line-entry system is a specification in form of a line notation for describing the structure of chemical species using short ASCII strings. SMILES strings can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the molecules, the original SMILES specification was initiated in the 1980s. It has since modified and extended. In 2007, a standard called OpenSMILES was developed in the open-source chemistry community. Other linear notations include the Wiswesser Line Notation, ROSDAL and SLN, the original SMILES specification was initiated by David Weininger at the USEPA Mid-Continent Ecology Division Laboratory in Duluth in the 1980s. The Environmental Protection Agency funded the project to develop SMILES. It has since modified and extended by others, most notably by Daylight Chemical Information Systems. In 2007, a standard called OpenSMILES was developed by the Blue Obelisk open-source chemistry community. Other linear notations include the Wiswesser Line Notation, ROSDAL and SLN, in July 2006, the IUPAC introduced the InChI as a standard for formula representation. SMILES is generally considered to have the advantage of being slightly more human-readable than InChI, the term SMILES refers to a line notation for encoding molecular structures and specific instances should strictly be called SMILES strings. However, the term SMILES is also used to refer to both a single SMILES string and a number of SMILES strings, the exact meaning is usually apparent from the context. The terms canonical and isomeric can lead to confusion when applied to SMILES. The terms describe different attributes of SMILES strings and are not mutually exclusive, typically, a number of equally valid SMILES strings can be written for a molecule. For example, CCO, OCC and CC all specify the structure of ethanol, algorithms have been developed to generate the same SMILES string for a given molecule, of the many possible strings, these algorithms choose only one of them. This SMILES is unique for each structure, although dependent on the algorithm used to generate it. These algorithms first convert the SMILES to a representation of the molecular structure. A common application of canonical SMILES is indexing and ensuring uniqueness of molecules in a database, there is currently no systematic comparison across commercial software to test if such flaws exist in those packages. SMILES notation allows the specification of configuration at tetrahedral centers, and these are structural features that cannot be specified by connectivity alone and SMILES which encode this information are termed isomeric SMILES
9.
Chemical formula
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These are limited to a single typographic line of symbols, which may include subscripts and superscripts. A chemical formula is not a name, and it contains no words. Although a chemical formula may imply certain simple chemical structures, it is not the same as a full chemical structural formula. Chemical formulas can fully specify the structure of only the simplest of molecules and chemical substances, the simplest types of chemical formulas are called empirical formulas, which use letters and numbers indicating the numerical proportions of atoms of each type. Molecular formulas indicate the numbers of each type of atom in a molecule. For example, the formula for glucose is CH2O, while its molecular formula is C6H12O6. This is possible if the relevant bonding is easy to show in one dimension, an example is the condensed molecular/chemical formula for ethanol, which is CH3-CH2-OH or CH3CH2OH. For reasons of structural complexity, there is no condensed chemical formula that specifies glucose, chemical formulas may be used in chemical equations to describe chemical reactions and other chemical transformations, such as the dissolving of ionic compounds into solution. A chemical formula identifies each constituent element by its chemical symbol, in empirical formulas, these proportions begin with a key element and then assign numbers of atoms of the other elements in the compound, as ratios to the key element. For molecular compounds, these numbers can all be expressed as whole numbers. For example, the formula of ethanol may be written C2H6O because the molecules of ethanol all contain two carbon atoms, six hydrogen atoms, and one oxygen atom. Some types of compounds, however, cannot be written with entirely whole-number empirical formulas. An example is boron carbide, whose formula of CBn is a variable non-whole number ratio with n ranging from over 4 to more than 6.5. When the chemical compound of the consists of simple molecules. These types of formulas are known as molecular formulas and condensed formulas. A molecular formula enumerates the number of atoms to reflect those in the molecule, so that the formula for glucose is C6H12O6 rather than the glucose empirical formula. However, except for very simple substances, molecular chemical formulas lack needed structural information, for simple molecules, a condensed formula is a type of chemical formula that may fully imply a correct structural formula. For example, ethanol may be represented by the chemical formula CH3CH2OH
10.
Melting point
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The melting point of a solid is the temperature at which it changes state from solid to liquid at atmospheric pressure. At the melting point the solid and liquid phase exist in equilibrium, the melting point of a substance depends on pressure and is usually specified at standard pressure. When considered as the temperature of the change from liquid to solid. Because of the ability of some substances to supercool, the point is not considered as a characteristic property of a substance. For most substances, melting and freezing points are approximately equal, for example, the melting point and freezing point of mercury is 234.32 kelvins. However, certain substances possess differing solid-liquid transition temperatures, for example, agar melts at 85 °C and solidifies from 31 °C to 40 °C, such direction dependence is known as hysteresis. The melting point of ice at 1 atmosphere of pressure is close to 0 °C. In the presence of nucleating substances the freezing point of water is the same as the melting point, the chemical element with the highest melting point is tungsten, at 3687 K, this property makes tungsten excellent for use as filaments in light bulbs. Many laboratory techniques exist for the determination of melting points, a Kofler bench is a metal strip with a temperature gradient. Any substance can be placed on a section of the strip revealing its thermal behaviour at the temperature at that point, differential scanning calorimetry gives information on melting point together with its enthalpy of fusion. A basic melting point apparatus for the analysis of crystalline solids consists of an oil bath with a transparent window, the several grains of a solid are placed in a thin glass tube and partially immersed in the oil bath. The oil bath is heated and with the aid of the melting of the individual crystals at a certain temperature can be observed. In large/small devices, the sample is placed in a heating block, the measurement can also be made continuously with an operating process. For instance, oil refineries measure the point of diesel fuel online, meaning that the sample is taken from the process. This allows for more frequent measurements as the sample does not have to be manually collected, for refractory materials the extremely high melting point may be determined by heating the material in a black body furnace and measuring the black-body temperature with an optical pyrometer. For the highest melting materials, this may require extrapolation by several hundred degrees, the spectral radiance from an incandescent body is known to be a function of its temperature. An optical pyrometer matches the radiance of a body under study to the radiance of a source that has been previously calibrated as a function of temperature, in this way, the measurement of the absolute magnitude of the intensity of radiation is unnecessary. However, known temperatures must be used to determine the calibration of the pyrometer, for temperatures above the calibration range of the source, an extrapolation technique must be employed
11.
Aqueous solution
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An aqueous solution is a solution in which the solvent is water. It is usually shown in chemical equations by appending to the relevant chemical formula, for example, a solution of table salt, or sodium chloride, in water would be represented as Na+ + Cl−. The word aqueous means pertaining to, related to, similar to, as water is an excellent solvent and is also naturally abundant, it is a ubiquitous solvent in chemistry. Substances that are hydrophobic often do not dissolve well in water, an example of a hydrophilic substance is sodium chloride. Acids and bases are aqueous solutions, as part of their Arrhenius definitions, the ability of a substance to dissolve in water is determined by whether the substance can match or exceed the strong attractive forces that water molecules generate between themselves. If the substance lacks the ability to dissolve in water the molecules form a precipitate, reactions in aqueous solutions are usually metathesis reactions. Metathesis reactions are another term for double-displacement, that is, when a cation displaces to form a bond with the other anion. The cation bonded with the latter anion will dissociate and bond with the other anion, aqueous solutions that conduct electric current efficiently contain strong electrolytes, while ones that conduct poorly are considered to have weak electrolytes. Those strong electrolytes are substances that are ionized in water. Nonelectrolytes are substances that dissolve in water yet maintain their molecular integrity, examples include sugar, urea, glycerol, and methylsulfonylmethane. When writing the equations of reactions, it is essential to determine the precipitate. To determine the precipitate, one must consult a chart of solubility, soluble compounds are aqueous, while insoluble compounds are the precipitate. Remember that there may not always be a precipitate, when performing calculations regarding the reacting of one or more aqueous solutions, in general one must know the concentration, or molarity, of the aqueous solutions. Solution concentration is given in terms of the form of the prior to it dissolving. Metal ions in aqueous solution Solubility Dissociation Acid-base reaction theories Properties of water Zumdahl S.1997, 4th ed. Boston, Houghton Mifflin Company
12.
Acid dissociation constant
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An acid dissociation constant, Ka, is a quantitative measure of the strength of an acid in solution. It is the constant for a chemical reaction known as dissociation in the context of acid–base reactions. In the example shown in the figure, HA represents acetic acid, and A− represents the acetate ion, the chemical species HA, A− and H3O+ are said to be in equilibrium when their concentrations do not change with the passing of time. The definition can then be more simply H A ⇌ A − + H +, K a = This is the definition in common usage. A weak acid has a pKa value in the approximate range −2 to 12 in water, pKa values for strong acids can, however, be estimated by theoretical means. The definition can be extended to non-aqueous solvents, such as acetonitrile and dimethylsulfoxide. Denoting a solvent molecule by S H A + S ⇌ A − + S H +, K a = When the concentration of solvent molecules can be taken to be constant, K a =, as before. The value of pKa also depends on structure of the acid in many ways. For example, Pauling proposed two rules, one for successive pKa of polyprotic acids, and one to estimate the pKa of oxyacids based on the number of =O and −OH groups. Other structural factors that influence the magnitude of the dissociation constant include inductive effects, mesomeric effects. Hammett type equations have frequently applied to the estimation of pKa. The quantitative behaviour of acids and bases in solution can be only if their pKa values are known. These calculations find application in different areas of chemistry, biology, medicine. Acid dissociation constants are essential in aquatic chemistry and chemical oceanography. In living organisms, acid–base homeostasis and enzyme kinetics are dependent on the pKa values of the acids and bases present in the cell. According to Arrheniuss original definition, an acid is a substance that dissociates in solution, releasing the hydrogen ion H+. The equilibrium constant for this reaction is known as a dissociation constant. Brønsted and Lowry generalised this further to an exchange reaction
13.
Phytochemical
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Phytochemicals are chemical compounds produced by plants, generally to help them thrive or thwart competitors, predators, or pathogens. The name comes from the Greek word phyto, meaning plant, some phytochemicals have been used as poisons and others as traditional medicine. As a term, phytochemicals is generally used to describe plant compounds that are under research with unestablished effects on health and are not scientifically defined as essential nutrients, plants are composed entirely of chemicals of various kinds. Phytochemicals are chemicals produced by plants through primary or secondary metabolism and they generally have biological activity in the plant host and play a role in plant growth or defense against competitors, pathogens, or predators. Phytochemicals generally are regarded as research compounds rather than essential nutrients because proof of their health effects has not been established yet. Phytochemicals under research can be classified into categories, such as carotenoids and polyphenols, which include phenolic acids, flavonoids. Flavonoids can be divided into groups based on their similar chemical structure, such as anthocyanins, flavones, flavanones, and isoflavones. Flavanols further are classified as catechins, epicatechins, and proanthocyanidins, without specific knowledge of their cellular actions or mechanisms, phytochemicals have been used as poison and in traditional medicine. The tropane alkaloids of A. belladonna were used as poisons, as of 2017, the biological activities for most phytochemicals are unknown or poorly understood, in isolation or as part of foods. Phytochemicals with established roles in the body are classified as essential nutrients, some phytochemicals are known phytotoxins that are toxic to humans, for example aristolochic acid is carcinogenic at low doses. Some phytochemicals are antinutrients that interfere with the absorption of nutrients, others, such as some polyphenols and flavonoids, may be pro-oxidants in high ingested amounts. Phytochemical supplements are recommended by health authorities for improving health nor approved by regulatory agencies for health claims on product labels. For example, systematic reviews and/or meta-analyses indicate weak or no evidence for phytochemicals from plant food consumption having an effect on breast, lung, Phytochemicals in freshly harvested plant foods may be degraded by processing techniques, including cooking. The main cause of loss from cooking is thermal decomposition. Food processing techniques like mechanical processing can also free carotenoids and other phytochemicals from the food matrix, an Evidence – Based Approach to Dietary Phytochemicals. Rosa, L. A. de la / Alvarez-Parrilla, E. / González-Aguilar, fruit and Vegetable Phytochemicals, Chemistry, Nutritional Value and Stability. Dr. Dukes Phytochemical and Ethnobotanical Databases – United States Department of Agriculture
14.
Cell wall
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A cell wall is a structural layer surrounding some types of cells, situated outside the cell membrane. It can be tough, flexible, and sometimes rigid and it provides the cell with both structural support and protection, and also acts as a filtering mechanism. Cell walls are present in most prokaryotes, in algae, plants and fungi, a major function is to act as pressure vessels, preventing over-expansion of the cell when water enters. The composition of cell walls varies between species and may depend on type and developmental stage. The primary cell wall of plants is composed of the polysaccharides cellulose, hemicellulose. Often, other such as lignin, suberin or cutin are anchored to or embedded in plant cell walls. Algae possess walls made of glycoproteins and polysaccharides such as carrageenan, in bacteria, the cell wall is composed of peptidoglycan. The cell walls of archaea have various compositions, and may be formed of glycoprotein S-layers, pseudopeptidoglycan, Fungi possess cell walls made of the glucosamine polymer chitin. Unusually, diatoms have a wall composed of biogenic silica. A plant cell wall was first observed and named by Robert Hooke in 1665, in 1804, Karl Rudolphi and J. H. F. Link proved that cells had independent cell walls, before, it had been thought that cells shared walls and that fluid passed between them this way. The mode of formation of the wall was controversial in the 19th century. Hugo von Mohl advocated the idea that the wall grows by apposition. Carl Nägeli believed that the growth of the wall in thickness, each theory was improved in the following decades, the apposition theory by Eduard Strasburger, and the intussusception theory by Julius Wiesner. In 1930, Ernst Münch coined the term apoplast in order to separate the living symplast from the dead plant region, Cell walls serve similar purposes in those organisms that possess them. They may give cells rigidity and strength, offering protection against mechanical stress, in multicellular organisms, they permit the organism to build and hold a definite shape. Cell walls also limit the entry of large molecules that may be toxic to the cell and they further permit the creation of stable osmotic environments by preventing osmotic lysis and helping to retain water. Their composition, properties, and form may change during the cell cycle, in most cells, the cell wall is flexible, meaning that it will bend rather than holding a fixed shape, but has considerable tensile strength
15.
Aromatic
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Aromatic molecules are very stable, and do not break apart easily to react with other substances. Organic compounds that are not aromatic are classified as aliphatic compounds—they might be cyclic, since the most common aromatic compounds are derivatives of benzene, the word “aromatic” occasionally refers informally to benzene derivatives, and so it was first defined. Nevertheless, many aromatic compounds exist. In living organisms, for example, the most common aromatic rings are the bases in RNA and DNA. An aromatic functional group or other substituent is called an aryl group, the earliest use of the term aromatic was in an article by August Wilhelm Hofmann in 1855. Hofmann used the term for a class of compounds, many of which have odors. In terms of the nature of the molecule, aromaticity describes a conjugated system often made of alternating single and double bonds in a ring. This configuration allows for the electrons in the pi system to be delocalized around the ring, increasing the molecules stability. The molecule cannot be represented by one structure, but rather a hybrid of different structures. These molecules cannot be found in one of these representations, with the longer single bonds in one location. Rather, the molecule exhibits bond lengths in between those of single and double bonds and this commonly seen model of aromatic rings, namely the idea that benzene was formed from a six-membered carbon ring with alternating single and double bonds, was developed by August Kekulé. The model for benzene consists of two forms, which corresponds to the double and single bonds superimposing to produce six one-and-a-half bonds. Benzene is a stable molecule than would be expected without accounting for charge delocalization. As is standard for resonance diagrams, the use of an arrow indicates that two structures are not distinct entities but merely hypothetical possibilities. Neither is a representation of the actual compound, which is best represented by a hybrid of these structures. A C=C bond is shorter than a C−C bond, but benzene is perfectly hexagonal—all six carbon–carbon bonds have the same length, intermediate between that of a single and that of a double bond. In a cyclic molecule with three alternating double bonds, cyclohexatriene, the length of the single bond would be 1.54 Å. However, in a molecule of benzene, the length of each of the bonds is 1.40 Å, a better representation is that of the circular π-bond, in which the electron density is evenly distributed through a π-bond above and below the ring
16.
Ferula
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Ferula is a genus of about 170 species of flowering plants in the carrot family, native to the Mediterranean region east to central Asia, mostly growing in arid climates. They are herbaceous plants growing to 1–4 m tall, with stout, hollow. The leaves are tripinnate or even more divided, with a stout basal sheath clasping the stem. The flowers are yellow, rarely white, produced in large umbels. Many plants of genus, especially F. communis are referred to as giant fennel. The Roman spice laser or laserpicium probably came from a species of Ferula, either a one or Ferula tingitana. Such rods were used for walking sticks, splints, for stirring boiling liquids, the ferula also shows up in mythological contexts. The main shaft of a thyrsus was traditionally made from this plant, the leaf aqueous-ethanol extract of Feruia foetida has shown antioxidant and antihemolytic activities
17.
Lignocellulose
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Lignocellulose refers to plant dry matter, so called lignocellulosic biomass. It is the most abundantly available raw material on the Earth for the production of biofuels and it is composed of carbohydrate polymers, and an aromatic polymer. These carbohydrate polymers contain different sugar monomers and they are bound to lignin. Lignocellulosic biomass can be classified into virgin biomass, waste biomass. Virgin biomass includes all naturally occurring terrestrial plants such as trees, bushes, waste biomass is produced as a low value byproduct of various industrial sectors such as agriculture and forestry. Energy crops are crops with high yield of lignocellulosic biomass produced to serve as a raw material for production of second generation biofuel, examples include switch grass, many crops are of interest for their ability to provide high yields of biomass and can be harvested multiple times each year. These include poplar trees and Miscanthus giganteus, the premier energy crop is sugarcane, which is a source of the readily fermentable sucrose and the lignocellulosic by-product bagasse. Lignocellulosic biomass is the feedstock for the pulp and paper industry and this energy-intensive industry focuses on the separation of the lignin and cellulosic fractions of the biomass. Lignocellulosic biomass, in the form of fuel, has a long history as a source of energy. Since the middle of the 20th century, the interest of biomass as a precursor to liquid fuels has increased, to be specific, the fermentation of lignocellulosic biomass to ethanol is an attractive route to fuels that supplements the fossil fuels. Biomass is a source of energy, Since it comes from plants. Aside from ethanol, many other lignocellulose-derived fuels are of potential interest, including butanol, dimethylfuran, one barrier to the production of ethanol from biomass is that the sugars necessary for fermentation are trapped inside the lignocellulose. Lignocellulose has evolved to resist degradation and to confer hydrolytic stability and this robustness or recalcitrance is attributable to the crosslinking between the polysaccharides and the lignin via ester and ether linkages. Ester linkages arise between oxidized sugars, the acids, and the phenols and phenylpropanols functionalities of the lignin. Another challenge to biomass fermentation is the percentage of pentoses in the hemicellulose, such as xylose. Unlike hexoses such as glucose, pentoses are difficult to ferment, the problems presented by the lignin and hemicellulose fractions are the foci of much contemporary research. A large sector of research into the exploitation of lignocellulosic biomass as a feedstock for bio-ethanol focuses particularly on the fungus Trichoderma reesei and these sugars can then be fermented, leading to bio-ethanol
18.
Pectin
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Pectin is a structural heteropolysaccharide contained in the primary cell walls of terrestrial plants. It was first isolated and described in 1825 by Henri Braconnot and it is produced commercially as a white to light brown powder, mainly extracted from citrus fruits, and is used in food as a gelling agent, particularly in jams and jellies. It is also used in dessert fillings, medicines, sweets, as a stabilizer in fruit juices and milk drinks, and as a source of dietary fiber. In plant biology, pectin consists of a set of polysaccharides that are present in most primary cell walls and are particularly abundant in the non-woody parts of terrestrial plants. Pectin is a component of the middle lamella, where it helps to bind cells together. The amount, structure and chemical composition of pectin differs among plants, within a plant over time, Pectin is an important cell wall polysaccharide that allows primary cell wall extension and plant growth. A similar process of cell separation caused by the breakdown of pectin occurs in the zone of the petioles of deciduous plants at leaf fall. Pectin is a part of the human diet, but does not contribute significantly to nutrition. The daily intake of pectin from fruits and vegetables can be estimated to be around 5 g, in human digestion, pectin binds to cholesterol in the gastrointestinal tract and slows glucose absorption by trapping carbohydrates. Pectin is thus a soluble dietary fiber, Pectin has been observed to have DNA repair properties. Pectinaceous surface pellicles, which are rich in pectin, create a layer that holds in dew that helps the cell repair its DNA. Consumption of pectin has been shown to reduce cholesterol levels. The mechanism appears to be an increase of viscosity in the intestinal tract, in the large intestine and colon, microorganisms degrade pectin and liberate short-chain fatty acids that have positive influence on health. A study found a mean of 4.5 ppm methanol in the breath of subjects. The mean endogenous methanol production in humans of 0.45 g/d may be metabolized from pectin found in fruit, methanol is poisonous to the central nervous system and may cause blindness, coma, and death. However, in amounts, methanol is a natural endogenous compound found in normal. Pectins, also known as polysaccharides, are rich in galacturonic acid. Several distinct polysaccharides have been identified and characterised within the pectic group, homogalacturonans are linear chains of α--linked D-galacturonic acid
19.
Lignin
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Lignin is a class of complex organic polymers that form important structural materials in the support tissues of vascular plants and some algae. Lignins are particularly important in the formation of walls, especially in wood and bark, because they lend rigidity. Chemically, lignins are cross-linked phenolic polymers and he named the substance “lignine”, which is derived from the Latin word lignum, meaning wood. It is one of the most abundant organic polymers on Earth, lignin constitutes 30% of non-fossil organic carbon and 20-35% of the dry mass of wood. The Carboniferous Period is in part defined by the evolution of lignin, the composition of lignin varies from species to species. An example of composition from a sample is 63. 4% carbon,5. 9% hydrogen,0. 7% ash. As a biopolymer, lignin is unusual because of its heterogeneity and its most commonly noted function is the support through strengthening of wood in vascular plants. Global commercial production of lignin is around 1.1 million metric tons per year and is used in a range of low volume, niche applications where the form. Lignin fills the spaces in the wall between cellulose, hemicellulose, and pectin components, especially in vascular and support tissues, xylem tracheids, vessel elements. It is covalently linked to hemicellulose and therefore cross-links different plant polysaccharides, conferring mechanical strength to the cell wall and it is particularly abundant in compression wood but scarce in tension wood, which are types of reaction wood. Lignin plays a part in conducting water in plant stems. The polysaccharide components of plant cell walls are highly hydrophilic and thus permeable to water, the crosslinking of polysaccharides by lignin is an obstacle for water absorption to the cell wall. Thus, lignin makes it possible for the vascular tissue to conduct water efficiently. Lignin is present in all plants, but not in bryophytes. However, it is present in red algae, which seems to suggest that the ancestor of plants. This would suggest that its function was structural, it plays this role in the red alga Calliarthron. Another possibility is that the lignins in red algae and in plants are result of convergent evolution, lignin plays a significant role in the carbon cycle, sequestering atmospheric carbon into the living tissues of woody perennial vegetation. Lignin is one of the most slowly decomposing components of dead vegetation, the resulting soil humus, in general, holds nutrients onto its surface, and hence increases its cation exchange capacity and moisture retention, hence it increases the productivity of soil
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Chlorogenic acid
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Chlorogenic acid is a natural chemical compound which is the ester of caffeic acid and -quinic acid. It is an important biosynthetic intermediate, chlorogenic acid is an important intermediate in lignin biosynthesis. This compound, known as an antioxidant, may also slow the release of glucose into the bloodstream after a meal, the term chlorogenic acids can also refer to a related family of esters of hydroxycinnamic acids with quinic acid. Despite the chloro of the name, chlorogenic acids contain no chlorine, instead, the name comes from the Greek χλωρός and -γένος, because of the green color produced when chlorogenic acids are oxidized. Structurally, chlorogenic acid is the ester formed between caffeic acid and the 3-hydroxyl position of L-quinic acid, isomers of chlorogenic acid include the caffeoyl ester at other hydroxyl sites on the quinic acid ring, 4-O-caffeoylquinic acid and 5-O-caffeoylquinic acid. The epimer at position 1 has not yet been reported and it should be noted that there is considerable ambiguity about the atom-numbering of chlorogenic acid. The order of numbering of atoms on the quinic acid ring was reversed in 1976 following IUPAC guidelines, with the consequence that 3-CQA became 5-CQA and this article uses the original numbering, which was exclusive prior to 1976. Thereafter researchers and manufacturers have been divided, with numbering systems in use. Even the 1976 IUPAC recommendations are not entirely satisfactory when applied to some of the less common chlorogenic acids, structures having more than one caffeic acid group are called isochlorogenic acids, and can be found in coffee. There are several isomers, such as 3, 4-dicaffeoylquinic acid and 3, 5-dicaffeoylquinic acid, chlorogenic acid is freely soluble in ethanol and acetone. Chlorogenic acid can be found in the bamboo Phyllostachys edulis. as well as in other plants. Chlorogenic acid can be found in the shoots of common heather, chlorogenic acid and the related compounds cryptochlorogenic acid, and neochlorogenic acid have been found in the leaves of Hibiscus sabdariffa, a popular tea product worldwide. Isomers of chlorogenic acid are found in potatoes, chlorogenic acid is the most abundant phenolic acid in the flesh of eggplants. It is one of the phenolic compounds identified in peach. It is also found in prunes and it also is one of the phenols found in green coffee bean extract and in green tea. Chlorogenic acid is marketed under the tradename Svetol, a green coffee extract, as a food additive used in coffee products, chewing gum, and mints. Dried sunflower leaves collected immediately after opening are processed into 98. 38% chlorogenic acid extract, review articles in 2011 and 2014 report modest blood pressure lowering effects from chlorogenic acid administration. No studies have appeared to assess possible interactions with drugs or advisability in patients being treated for low blood pressure
21.
Caffeic acid
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Caffeic acid is an organic compound that is classified as a hydroxycinnamic acid. This yellow solid consists of both phenolic and acrylic functional groups and it is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal components of plant biomass and its residues. Caffeic acid can be found in the bark of Eucalyptus globulus and it can also be found in the freshwater fern Salvinia molesta or in the mushroom Phellinus linteus. Caffeic acid is found at a very modest level in coffee and it is one of the main natural phenols in argan oil. It is at a high level in black chokeberry and in fairly high level in lingonberry. It is also high in the South American herb yerba mate. It is also found in grain, and in rye grain. Caffeic acid, which is unrelated to caffeine, is biosynthesized by hydroxylation of coumaroyl ester of quinic acid and this hydroxylation produces the caffeic acid ester of shikimic acid, which converts to chlorogenic acid. It is the precursor to acid, coniferyl alcohol, and sinapyl alcohol. The transformation to ferulic acid is catalyzed by the enzyme caffeate O-methyltransferase, caffeic acid and its derivative caffeic acid phenethyl ester are produced in many kinds of plants. Dihydroxyphenylalanine ammonia-lyase was presumed to use 3, 4-dihydroxy-L-phenylalanine to produce trans-caffeate, however, the EC number for this purported enzyme was deleted in 2007, as no evidence has emerged for its existence. Caffeate O-methyltransferase is a responsible for the transformation of caffeic acid into ferulic acid. Caffeic acid and related o-diphenols are rapidly oxidized by o-diphenol oxidases in tissue extracts, caffeate 3, 4-dioxygenase is an enzyme that uses caffeic acid and oxygen to produce 3--cis, cis-muconate. 3-O-caffeoylshikimic acid and its isomers, are enzymic browning substrates found in dates, caffeic acid is an antioxidant in vitro and also in vivo. Caffeic acid also shows immunomodulatory and anti-inflammatory activity, caffeic acid outperformed the other antioxidants, reducing aflatoxin production by more than 95 percent. The studies are the first to show that stress that would otherwise trigger or enhance Aspergillus flavus aflatoxin production can be stymied by caffeic acid. This opens the door to use as a natural fungicide by supplementing trees with antioxidants, studies of the carcinogenicity of caffeic acid have mixed results. Some studies have shown that it inhibits carcinogenesis, and other experiments show carcinogenic effects, oral administration of high doses of caffeic acid in rats has caused stomach papillomas
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Large intestine
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The large intestine, or the large bowel, is the last part of the gastrointestinal tract and of the digestive system in vertebrates. Water is absorbed here and the waste material is stored as feces before being removed by defecation. Most sources define the large intestine as the combination of the cecum, colon, rectum, some other sources exclude the anal canal. In humans, the large intestine begins in the right region of the pelvis, just at or below the waist. It then continues as the colon ascending the abdomen, across the width of the cavity as the transverse colon. Overall, in humans, the intestine is about 1.5 metres long. The colon is the last part of the digestive system and it extracts water and salt from solid wastes before they are eliminated from the body and is the site in which flora-aided fermentation of unabsorbed material occurs. Unlike the small intestine, the colon does not play a role in absorption of foods. About 1.5 litres or 45 ounces of water arrives in the each day. The length of the human male colon is 166 cm, on average. In mammals, the colon consists of five sections, the cecum plus the colon, the transverse colon, the descending colon, the sigmoid colon. Retroperitoneal organs in general do not have a covering of peritoneum. Intraperitoneal organs are completely surrounded by peritoneum and are therefore mobile, of the colon, the ascending colon, descending colon and rectum are retroperitoneal, while the cecum, appendix, transverse colon and sigmoid colon are intraperitoneal. This is important as it affects which organs can be accessed during surgery. The ascending colon is the first of four sections of the large intestine and it is connected to the small intestine by a section of bowel called the cecum. The ascending colon runs upwards through the abdominal cavity toward the transverse colon for approximately eight inches, one of the main functions of the colon is to remove the water and other key nutrients from waste material and recycle it. As the waste material exits the small intestine through the valve, it will move into the cecum. The unwanted waste material is moved upwards toward the transverse colon by the action of peristalsis, the ascending colon is sometimes attached to the appendix via Gerlachs valve
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Gut flora
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Gut flora is the complex community of microorganisms that live in the digestive tracts of humans and other animals, including insects. The gut metagenome is the aggregate of all the genomes of gut microbiota, the gut is one niche that human microbiota inhabit. In humans, the gut microbiota has the largest numbers of bacteria, the relationship between some gut flora and humans is not merely commensal, but rather a mutualistic relationship. Some human gut microorganisms benefit the host by fermenting dietary fiber into short-chain fatty acids, such as acid and butyric acid. Intestinal bacteria also play a role in synthesizing vitamin B and vitamin K as well as metabolizing bile acids, sterols, the composition of human gut flora changes over time, when the diet changes, and as overall health changes. The microbial composition of the gut flora varies across the digestive tract, in the stomach and small intestine, relatively few species of bacteria are generally present. The colon, in contrast, contains a densely-populated microbial ecosystem with up to 1012 cells per gram of intestinal content and these bacteria represent between 300 and 1000 different species. However, 99% of the come from about 30 or 40 species. As a consequence of their abundance in the intestine, bacteria also make up to 60% of the dry mass of feces, fungi, archaea, and viruses are also present in the gut flora, but less is known about their activities. Over 99% of the bacteria in the gut are anaerobes, but in the cecum and it is estimated that these gut flora have around a hundred times as many genes in total as there are in the human genome. Many species in the gut have not been studied outside of their hosts because most cannot be cultured, while there are a small number of core species of microbes shared by most individuals, populations of microbes can vary widely among different individuals. Within an individual, microbe populations stay fairly constant over time, even though some alterations may occur with changes in lifestyle, diet, the Human Microbiome Project has set out to better describe the microflora of the human gut and other body locations. The four dominant bacterial phyla in the gut are Firmicutes, Bacteroidetes, Actinobacteria. Most bacteria belong to the genera Bacteroides, Clostridium, Faecalibacterium, Eubacterium, Ruminococcus, Peptococcus, Peptostreptococcus, other genera, such as Escherichia and Lactobacillus, are present to a lesser extent. Species from the genus Bacteroides alone constitute about 30% of all bacteria in the gut, fungal genera that have been detected in the gut include Candida, Saccharomyces, Aspergillus, Penicillium, Rhodotorula, Trametes, Pleospora, Sclerotinia, Bullera, and Galactomyces, among others. Rhodotorula is most frequently found in individuals with inflammatory bowel disease while Candida is most frequently found in individuals with hepatitis B cirrhosis, archaea constitute another large class of gut flora which are important in the metabolism of the bacterial products of fermentation. An enterotype is a classification of living based on its bacteriological ecosystem in the human gut microbiome not dictated by age, gender, body weight. There are indications that long-term diet influences enterotype, three human enterotypes have been proposed, but these claims remain highly controversial
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Bran
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Bran, also known as millers bran, is the hard outer layers of cereal grain. It consists of the combined aleurone and pericarp, along with germ, it is an integral part of whole grains, and is often produced as a byproduct of milling in the production of refined grains. When bran is removed from grains, the grains lose a portion of their nutritional value, bran is present in and may be in any cereal grain, including rice, corn, wheat, oats, barley, rye and millet. Bran is not the same as chaff, coarser scaly material surrounding the grain, bran is particularly rich in dietary fiber and essential fatty acids and contains significant quantities of starch, protein, vitamins, and dietary minerals. It is also a source of acid, an antinutrient that prevents nutrient absorption. The high oil content of bran makes it subject to rancidification, bran is often heat-treated to increase its longevity. Rice bran is a byproduct of the milling process. A major rice bran fraction contains 12%-13% oil and highly unsaponifiable components and this fraction contains tocotrienols, gamma-oryzanol and beta-sitosterol, all these constituents may contribute to the lowering of the plasma levels of the various parameters of the lipid profile. Rice bran also contains a level of dietary fibres. In addition, it also contains ferulic acid, which is also a component of the structure of nonlignified cell walls, however, some research suggests there are levels of inorganic arsenic present in rice bran. One study found the levels to be 20% higher than in drinking water, other types of bran contain less arsenic than rice bran, and are just as nutrient-rich. Bran is often used to enrich breads and breakfast cereals, especially for the benefit of those wishing to increase their intake of dietary fiber, bran may also be used for pickling as in the tsukemono of Japan. In Romania and Moldova, the wheat bran is usually used when preparing borș soup. Rice bran in particular finds many uses in Japan, where it is known as nuka, besides using it for pickling, Japanese people also add it to the water when boiling bamboo shoots, and use it for dish washing. In Kitakyushu City, it is called jinda and used for stewing fish, rice bran and rice bran oil are also widely used in Japan as a natural beauty treatment. In Myanmar, rice bran, called phwei-bya, is mixed with ash, rice bran is also stuck to commercial ice blocks to hinder them from melting. It is also burned for fuel for mills in the rice growing regions of the Irrawaddy delta. Bran oil may be extracted for use by itself for industrial purposes, or as a cooking oil
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Wheat
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Wheat is a cereal grain, originally from the Levant region but now cultivated worldwide. In 2016, world production of wheat was 749 million tonnes, making it the second most-produced cereal after maize, since 1960, world production of wheat and other grain crops has tripled and is expected to grow further through the middle of the 21st Century. This grain is grown on land area than any other commercial food. World trade in wheat is greater than for all other crops combined, globally, wheat is the leading source of vegetal protein in human food, having a protein content of about 13%, which is relatively high compared to other major cereals and staple foods. The archaeological record suggests that wheat was first cultivated in the regions of the Fertile Crescent around 9600 BCE. In a small part of the population, gluten – the major part of wheat protein – can trigger coeliac disease, non-coeliac gluten sensitivity, gluten ataxia. Cultivation and repeated harvesting and sowing of the grains of wild grasses led to the creation of domestic strains, in domesticated wheat, grains are larger, and the seeds remain attached to the ear by a toughened rachis during harvesting. In wild strains, a more fragile rachis allows the ear to easily shatter, as the traits that improve wheat as a food source also involve the loss of the plants natural seed dispersal mechanisms, highly domesticated strains of wheat cannot survive in the wild. Cultivation of wheat began to spread beyond the Fertile Crescent after about 8000 BCE, jared Diamond traces the spread of cultivated emmer wheat starting in the Fertile Crescent sometime before 8800 BCE. Archaeological analysis of wild emmer indicates that it was first cultivated in the southern Levant with finds dating back as far as 9600 BCE, Genetic analysis of wild einkorn wheat suggests that it was first grown in the Karacadag Mountains in southeastern Turkey. Dated archeological remains of wheat in settlement sites near this region, including those at Abu Hureyra in Syria. With the anomalous exception of two grains from Iraq ed-Dubb, the earliest carbon-14 date for einkorn wheat remains at Abu Hureyra is 7800 to 7500 years BCE. Remains of harvested emmer from several sites near the Karacadag Range have been dated to between 8600 and 8400 BCE, that is, in the Neolithic period and these remains were dated by Willem van Zeist and his assistant Johanna Bakker-Heeres to 8800 BCE. They also concluded that the settlers of Tell Aswad did not develop this form of emmer themselves, the cultivation of emmer reached Greece, Cyprus and India by 6500 BCE, Egypt shortly after 6000 BCE, and Germany and Spain by 5000 BCE. The early Egyptians were developers of bread and the use of the oven, by 3000 BCE, wheat had reached the British Isles and Scandinavia. A millennium later it reached China, the oldest evidence for hexaploid wheat has been confirmed through DNA analysis of wheat seeds, dating to around 6400-6200 BCE, recovered from Çatalhöyük. The first identifiable bread wheat with sufficient gluten for yeasted breads has been identified using DNA analysis in samples from a dating to approximately 1350 BCE at Assiros in Macedonia. From Asia, wheat continued to spread throughout Europe, in the British Isles, wheat straw was used for roofing in the Bronze Age, and was in common use until the late 19th century
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Glucoside
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A glucoside is a glycoside that is derived from glucose. Glucosides are common in plants, but rare in animals, glucose is produced when a glucoside is hydrolysed by purely chemical means, or decomposed by fermentation or enzymes. The name was given to plant products of this nature, in which the other part of the molecule was, in the greater number of cases. Although glucose is the most common sugar present in glucosides, many are known which yield rhamnose or iso-dulcite, the simplest glucosides are the alkyl ethers which have been obtained by reacting hydrochloric acid on alcoholic glucose solutions. A better method of preparation is to dissolve solid anhydrous glucose in methanol containing hydrochloric acid, a mixture of alpha- and beta-methylglucoside results. Classification of the glucosides is a matter of some intricacy, a group may also be constructed to include the cyanogenic glucosides, i. e. those containing prussic acid. Alternate classifications follow a classification, which has several advantages, in particular. In this article the chemical classification will be followed, and only the important compounds will be discussed herein. These are generally mustard oils, which are characterized by a taste, their principal occurrence is in mustard. Sinigrin, or the salt of inyronic acid not only occurs in mustard seed. Hydrolysis with baryta, or decomposition by the ferment myrosin, gives glucose, allyl mustard oil, sinalbin occurs in white pepper, it decomposes to the mustard oil, glucose and sinapin, a compound of choline and sinapic acid. Jalapin or scammonin occurs in scammony, it hydrolyses to glucose and these are generally oxy and oxyaldehydic compounds. Benzoic acid derivatives The benzoyl derivative cellotropin has been used for tuberculosis, populin, which occurs in the leaves and bark of Populus tremula, is benzoyl salicin. Benzoyl-beta-D-glucoside is a found in Pteris ensiformis. Phenol derivatives There are a number of found in natural phenols and polyphenols, as, for example. Arbutin, which occurs in bearberry along with methyl arbutin, hydrolyses to hydroquinone, pharmacologically it acts as a urinary antiseptic and diuretic, Salicin, also termed saligenin and glucose occurs in the willow. The enzymes ptyalin and emulsin convert it into glucose and saligenin and this group contains a benzene and also an ethylene group, being derived from styrolene. Coniferin, C16H22O8, occurs in the cambium of conifer wood, emulsin converts it into glucose and coniferyl alcohol, while oxidation gives glycovanillin, which yields with emulsin, glucose and vanillin
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Flax
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Flax, Linum usitatissimum, is a member of the genus Linum in the family Linaceae. It is a food and fiber crop cultivated in regions of the world. The textiles made from flax are known in the Western countries as linen, and traditionally used for bed sheets, underclothes, the oil is known as linseed oil. In addition to referring to the plant itself, the word flax may refer to the fibers of the flax plant. The plant species is only as a cultivated plant, and appears to have been domesticated just once from the wild species Linum bienne. Several other species in the genus Linum are similar in appearance to L. usitatissimum, cultivated flax, including some that have similar blue flowers, some of these are perennial plants, unlike L. usitatissimum, which is an annual plant. Cultivated flax plants grow to 1.2 m tall, with slender stems, the leaves are glaucous green, slender lanceolate, 20–40 mm long, and 3 mm broad. The flowers are pale blue, 15–25 mm in diameter. The fruit is a round, dry capsule 5–9 mm in diameter, containing several brown seeds shaped like an apple pip. Flax was first domesticated in the Fertile Crescent region, evidence exists of a domesticated oilseed flax with increased seed size by 9,000 years ago from Tell Ramad in Syria. Use of the crop steadily spread, reaching as far as Switzerland, in China and India, domesticated flax was cultivated also by at least 5,000 years ago. Flax was extensively cultivated in ancient Egypt, where the walls had paintings of flowering flax. Egyptian priests only wore linen, as flax was considered a symbol of purity, phoenicians traded Egyptian linen throughout the Mediterranean, and the Romans used it for their sails. Eventually, Flanders became the center of the linen industry in the European Middle Ages. Since then, flax has lost its importance as a commercial crop, Flax is grown for its oil, used as a nutritional supplement, and as an ingredient in many wood-finishing products. Flax is also grown as a plant in gardens. Flax fibers are used to make linen, the Latin species name usitatissimum means most useful. Flax fibers are taken from the stem of the plant, and are two to three times as strong as those of cotton, additionally, flax fibers are naturally smooth and straight
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Barley
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Barley, a member of the grass family, is a major cereal grain grown in temperate climates globally. It was one of the first cultivated grains, particularly in Eurasia as early as 10,000 years ago, Barley has been used as animal fodder, as a source of fermentable material for beer and certain distilled beverages, and as a component of various health foods. It is used in soups and stews, and in barley bread of various cultures, Barley grains are commonly made into malt in a traditional and ancient method of preparation. In 2014, barley was ranked fourth among grains in quantity produced behind corn, rice, the Old English word for barley was bære, which traces back to Proto-Indo-European and is cognate to the Latin word farina flour. The direct ancestor of modern English barley in Old English was the derived adjective bærlic, the first citation of the form bærlic in the Oxford English Dictionary dates to around 966 CE, in the compound word bærlic-croft. The underived word bære survives in the north of Scotland as bere, the word barn, which originally meant barley-house, is also rooted in these words. Barley is a member of the grass family and it is a self-pollinating, diploid species with 14 chromosomes. The wild ancestor of domesticated barley, Hordeum vulgare subsp, spontaneum, is abundant in grasslands and woodlands throughout the Fertile Crescent area of Western Asia and northeast Africa, and is abundant in disturbed habitats, roadsides and orchards. Outside this region, the barley is less common and is usually found in disturbed habitats. However, in a study of genome-wide diversity markers, Tibet was found to be a center of domestication of cultivated barley. Wild barley has a spike, upon maturity, the spikelets separate. Domesticated barley has nonshattering spikes, making it easier to harvest the mature ears. The nonshattering condition is caused by a mutation in one of two linked genes known as Bt1 and Bt2, many cultivars possess both mutations. The nonshattering condition is recessive, so varieties of barley that exhibit this condition are homozygous for the mutant allele, spikelets are arranged in triplets which alternate along the rachis. In wild barley, only the central spikelet is fertile, while the two are reduced. This condition is retained in certain cultivars known as two-row barleys, a pair of mutations result in fertile lateral spikelets to produce six-row barleys. Recent genetic studies have revealed that a mutation in one gene, two-row barley has a lower protein content than six-row barley, thus a more fermentable sugar content. High-protein barley is best suited for animal feed, Malting barley is usually lower protein which shows more uniform germination, needs shorter steeping, and has less protein in the extract that can make beer cloudy
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Asterids
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In the APG IV system for the classification of flowering plants, the name asterids denotes a clade. Most of the taxa belonging to this clade had been referred to the Asteridae in the Cronquist system, the name asterids resembles the earlier botanical name but is intended to be the name of a clade rather than a formal ranked name, in the sense of the ICBN. The phylogenetic tree presented hereafter has been proposed by the APG IV project, genetic analysis carried out after APG II maintains that the sister to all other asterids are the Cornales. A second order that split from the base of the asterids are the Ericales, the remaining orders cluster into two clades, the lamiids and the campanulids. The structure of both of these clades has changed in APG III, in APG III system, the following clades were renamed, euasterids I → lamiids euasterids II → campanulids Asterids in Stevens, P. F. Angiosperm Phylogeny Website
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Eudicots
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The eudicots, Eudicotidae or eudicotyledons are a monophyletic clade of flowering plants that had been called tricolpates or non-magnoliid dicots by previous authors. The close relationships among flowering plants with tricolpate pollen grains was initially seen in studies of shared derived characters. These plants have a trait in their pollen grains of exhibiting three colpi or grooves paralleling the polar axis. Later molecular evidence confirmed the basis for the evolutionary relationships among flowering plants with tricolpate pollen grains. The term means true dicotyledons, as it contains the majority of plants that have been considered dicots and have characteristics of the dicots, the term eudicots has subsequently been widely adopted in botany to refer to one of the two largest clades of angiosperms, monocots being the other. The remaining angiosperms are sometimes referred to as basal angiosperms or paleodicots, the other name for the eudicots is tricolpates, a name which refers to the grooved structure of the pollen. Members of the group have tricolpate pollen, or forms derived from it and these pollens have three or more pores set in furrows called colpi. In contrast, most of the seed plants produce monosulcate pollen. The name tricolpates is preferred by some botanists to avoid confusion with the dicots, numerous familiar plants are eudicots, including many common food plants, trees, and ornamentals. Most leafy trees of midlatitudes also belong to eudicots, with exceptions being magnolias and tulip trees which belong to magnoliids, and Ginkgo biloba. The name eudicots is used in the APG system, of 1998 and it is applied to a clade, a monophyletic group, which includes most of the dicots. The eudicots can be divided into two groups, the basal eudicots and the core eudicots, basal eudicot is an informal name for a paraphyletic group. The core eudicots are a monophyletic group, a 2010 study suggested the core eudicots can be divided into two clades, Gunnerales and a clade called Pentapetalae, comprising all the remaining core eudicots
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Andes
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The Andes or Andean Mountains are the longest continental mountain range in the world. They are a range of highlands along the western edge of South America. This range is about 7,000 km long, about 200 to 700 km wide, the Andes extend from north to south through seven South American countries, Venezuela, Colombia, Ecuador, Peru, Bolivia, Argentina and Chile. Along their length, the Andes are split into several ranges, the Andes are the location of several high plateaus – some of which host major cities, such as Quito, Bogotá, Arequipa, Medellín, Sucre, Mérida and La Paz. The Altiplano plateau is the worlds second-highest after the Tibetan plateau and these ranges are in turn grouped into three major divisions based on climate, the Tropical Andes, the Dry Andes, and the Wet Andes. The Andes are the worlds highest mountain range outside of Asia, the highest mountain outside Asia, Mount Aconcagua, rises to an elevation of about 6,961 m above sea level. The peak of Chimborazo in the Ecuadorean Andes is farther from the Earths center than any other location on the Earths surface, the worlds highest volcanoes are in the Andes, including Ojos del Salado on the Chile-Argentina border, which rises to 6,893 m. The etymology of the word Andes has been debated, the majority consensus is that it derives from the Quechua word anti, which means east as in Antisuyu, one of the four regions of the Inca Empire. In the northern part of the Andes, the isolated Sierra Nevada de Santa Marta range is considered to be part of the Andes. The term cordillera comes from the Spanish word cordel, meaning rope, the Andes range is about 200 km wide throughout its length, except in the Bolivian flexure where it is about 640 kilometres wide. The Andes are the result of plate tectonics processes, caused by the subduction of oceanic crust beneath the South American plate. The main cause of the rise of the Andes is the compression of the rim of the South American Plate due to the subduction of the Nazca Plate. In the south, the Andes share a boundary with the former Patagonia Terrane. To the west, the Andes end at the Pacific Ocean, from a geographical approach, the Andes are considered to have their western boundaries marked by the appearance of coastal lowlands and a less rugged topography. The Andes Mountains also contain large quantities of iron ore located in mountains within the range. The Andean orogen has a series of bends or oroclines, the Bolivian Orocline is a seaward concave bending in the coast of South America and the Andes Mountains at about 18° S. At this point the orientation of the Andes turns from Northwest in Peru to South in Chile, the Andean segment north and south of the orocline have been rotated 15° to 20° counter clockwise and clockwise respectively. The Bolivian Orocline area overlaps with the area of maximum width of the Altiplano Plateau, the specific point at 18° S where the coastline bends is known as the Arica Elbow
32.
Legume
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A legume is a plant or its fruit or seed in the family Fabaceae. Legumes are grown agriculturally, primarily for their grain seed called pulse, for forage and silage. Well-known legumes include alfalfa, clover, peas, beans, lentils, lupin bean, mesquite, carob, soybeans, peanuts, Fabaceae is the most common family found in tropical rainforests and in dry forests in the Americas and Africa. A legume fruit is a dry fruit that develops from a simple carpel. A common name for type of fruit is a pod, although the term pod is also applied to a number of other fruit types, such as that of vanilla. Legumes are notable in that most of them have symbiotic nitrogen-fixing bacteria in structures called root nodules, for that reason, they play a key role in crop rotation. The term pulse, as used by the United Nations Food and this excludes green beans and green peas, which are considered vegetable crops. Also excluded are seeds that are grown for oil extraction. However, in usage, these distinctions are not always clearly made. Some Fabaceae, such as Scotch broom and other Genisteae, are leguminous but are not called legumes by farmers. Farmed legumes can belong to many classes, including forage, grain, blooms, pharmaceutical/industrial, fallow/green manure. Most commercially farmed species fill two or more roles simultaneously, depending upon their degree of maturity when harvested, grain legumes are cultivated for their seeds. The seeds are used for human and animal consumption or for the production of oils for industrial uses, grain legumes include beans, lentils, lupins, peas, and peanuts. Like other plant-based foods, pulses contain no cholesterol and little fat or sodium, Legumes are also an excellent source of resistant starch which is broken down by bacteria in the large intestine to produce short-chain fatty acids used by intestinal cells for food energy. Preliminary studies in humans include the potential for regular consumption of legumes in a diet to affect metabolic syndrome. There is evidence that a portion of pulses in a diet may lower blood pressure and reduce LDL cholesterol levels. Some, like alfalfa, clover, vetch, stylo, or Arachis, are sown in pasture, other forage legumes such as Leucaena or Albizia are woody shrub or tree species that are either broken down by livestock or regularly cut by humans to provide livestock feed. Legume species grown for their flowers include lupins, which are farmed commercially for their blooms as well as being popular in gardens worldwide, industrially farmed legumes include Indigofera and Acacia species, which are cultivated for dye and natural gum production, respectively
33.
Navy bean
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The navy bean, haricot, pearl haricot bean, boston bean, white pea bean, or pea bean, is a variety of the common bean native to the Americas, where it was domesticated. It is a small, dry white bean which is smaller than other types of white beans. It features in dishes as baked beans, and even pies. Unlike most canned vegetables, which much of their nutritive value in the canning process. The green bean or kidney bean plants, that produce navy beans may be either of the type or vining type. They are larger than navy beans, related to the bean and. They are used in minestrone soups, great northern, also called large white beans are also larger than navy beans but smaller than cannellini beans, with a flattened shape similar to lima beans. The large white beans known in Greece as gígantes and eléfantes are from the runner bean, white beans are the most abundant plant-based source of phosphatidylserine yet known. It contains notably high levels of apigenin, 452±192 µg/kg, which vary widely among legumes, consumption of baked beans has been shown to lower total cholesterol levels and low-density lipoprotein cholesterol. This might be at least partly explained by high content of navy bean. Saponins also exhibit antibacterial and anti-fungal activity, and have found to inhibit cancer cell growth. Furthermore, navy bean is the richest source of ferulic acid, dried and canned beans stay fresh longer by storing them in a pantry or other cool, dark place under 75 °F. With normal seed storage, seeds should last from one to four years for replanting, with a very large timetable for cooking for well-kept seeds, avoid beans which are discolored from the pure white color of these beans, as they may have been poorly handled while they dried
34.
Phaseolus vulgaris
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Phaseolus vulgaris, the common bean, is a herbaceous annual plant grown worldwide for its edible dry seed or unripe fruit. Raw or undercooked beans contain the toxin phytohaemagglutinin and its leaf is also occasionally used as a vegetable and the straw as fodder. The common bean is a variable species that has a long history of cultivation. All wild members of the species have a habit, but many cultivars are classified as bush beans or pole beans. These include the bean, the navy bean, the pinto bean. The other major types of commercially grown bean are the runner bean, Beans are grown in every continent except Antarctica. Brazil and India are the largest producers of dry beans, while China produces, by far, worldwide,23 million tonnes of dry common beans and 17.1 million tonnes of green beans were grown in 2010. Along with squash and maize, beans are one of the Three Sisters central to indigenous North American agriculture, the common bean is a highly variable species with a long history. Bush varieties form erect bushes 20–60 cm tall, while pole or running varieties form vines 2–3 m long, all varieties bear alternate, green or purple leaves, which are divided into three oval, smooth-edged leaflets, each 6–15 cm long and 3–11 cm wide. The white, pink, or purple flowers are about 1 cm long and these may be green, yellow, black, or purple in color, each containing 4–6 beans. The beans are smooth, plump, kidney-shaped, up to 1.5 cm long, range widely in color, and are often mottled in two or more colors. Similar to other beans, the bean is high in starch, protein, and dietary fiber, and is an excellent source of iron, potassium, selenium, molybdenum, thiamine, vitamin B6. Dry beans will keep indefinitely if stored in a cool, dry place, dried beans are almost always cooked by boiling, often after being soaked in water for several hours. While the soaking is not strictly necessary, it shortens cooking time, in addition, soaking beans removes 5 to 10% of the gas-producing sugars that can cause flatulence for some people. The methods include simple overnight soaking and the power soak method in which beans are boiled for three minutes and then set aside for 2–4 hours, before cooking, the soaking water is drained off and discarded. Dry common beans take longer to cook than most pulses, cooking times vary from one to four hours, in Mexico, Central America, and South America, the traditional spice used with beans is epazote, which is also said to aid digestion. In East Asia, a type of seaweed, kombu, is added to beans as they cook for the same purpose, salt, sugar, and acidic foods such as tomatoes may harden uncooked beans, resulting in seasoned beans at the expense of slightly longer cooking times. Dry beans may also be cooked and canned as refried beans, or whole with water, salt
35.
Macrotyloma uniflorum
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Macrotyloma uniflorum is one of the lesser known beans. The whole seeds of horse gram are generally used as cattle feed, however, it is consumed as a whole seed, as sprouts, or as whole meal in India, popular especially in southern Indian states. Medical uses of these legumes have been discussed, horse gram and moth bean are legumes of the tropics and subtropics, grown mostly under dry-land agriculture. The chemical composition is comparable with more commonly cultivated legumes, like other legumes, these are deficient in methionine and tryptophan, though horse gram is an excellent source of iron and molybdenum. Comparatively, horse gram seeds have higher trypsin inhibitor and hemagglutinin activities, natural phenols are mostly phenolic acids, namely,3, 4-dihydroxybenzoic, 4-hydroxybenzoic, vanillic, caffeic, p-coumaric, ferulic, syringic and sinapic acids. Dehusking, germination, cooking, and roasting have been shown to produce beneficial effects on quality of both the legumes. Though both require prolonged cooking, a solution has been shown to reduce cooking time and improve protein quality. Moth bean is mostly consumed as dhal or sprouts, in Telangana and Andhra Pradesh, horse gram is prescribed for persons suffering from jaundice or water retention, and as part of a weight-loss diet. It is considered helpful for iron deficiencies, and is considered helpful for maintaining body temperature in the winter season, ulavacharu is popular dish in Telangana and Andhra Pradesh, it is served in most of the Telugu-speaking peoples weddings and ceremonies and tastes wonderful with boiled rice. In Darjeeling and Sikkim, horse gram (called is considered a medicinal food and it is given to children suffering from mumps. Water in which gahat is soaked is taken by people suffering from kidney stones in the belief that this dissolves the crystals, gahats use is specially reserved for the cold winters, when its heat-producing properties are most useful. In Kerala, horse gram, is used in special kinds of dishes, in Tamil Nadu, horse gram (called கொள்ளு is commonly used in Tamil dishes, including kollu chutney, kollu porial, kollu avial, kollu sambar, and kollu rasam. In traditional siddha cuisine, horse gram is considered a food with medicinal qualities, in Maharashtra, and specifically the coastal Konkan region and Goa, horse gram is often used to make kulith usal, pithla, and laddu. In India, it is known as gahat, muthira, kulath, or kulthi. It is used to make popular dishes like kulitan saaru, kulitan upkari, kulitan ghassi, in Karnataka cuisine, ಹುರಳಿಸಾರು, ಹುರಳಿ is a main ingredient. Hurali is also used in such as usali, chutney, basaaru. In South Canara region of Karnataka, in Tulu, it is called kudu. In Odisha it is known by the name କୋଳଥ, gahat or kulath is a major ingredient in the food of Pahari region of northern India
36.
Bioavailability
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By definition, when a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered via other routes, its bioavailability generally decreases or may vary from patient to patient, Bioavailability is one of the essential tools in pharmacokinetics, as bioavailability must be considered when calculating dosages for non-intravenous routes of administration. Bioavailability is defined differently for drugs as opposed to dietary supplements primarily due to the method of administration and Food. Bioaccessibility is a related to bioavailability in the context of biodegradation. A molecule is said to be bioaccessible when is available to cross a cellular membrane from the environment. In pharmacology, bioavailability is a measurement of the rate and extent to which a drug reaches at the site of action and it is denoted by the letter f. Therefore, bioavailability for dietary supplements can be defined as the proportion of the administered substance capable of being absorbed, in both pharmacology and nutrition sciences, bioavailability is measured by calculating the area under curve of the drug concentration time profile. Bioavailability is commonly a factor in the production of crops. Toxic materials in soil, such as lead from paint may be rendered unavailable to animals ingesting contaminated soil by supplying phosphorus fertilizers in excess and it is the fraction of the drug absorbed through non-intravenous administration compared with the corresponding intravenous administration of the same drug. The comparison must be normalized, consequently, the amount absorbed is corrected by dividing the corresponding dose administered. The absolute bioavailability is the area under curve non-intravenous divided by AUC intravenous. For example, the formula for calculating F for a drug administered by the route is given below. If we compare the two different dosage forms having same active ingredients and compare the two drug bioavailability is called comparative bioavailability, although knowing the true extent of systemic absorption is clearly useful, in practice it is not determined as frequently as one may think. The reason for this is that its assessment requires a reference, that is. These limitations may be overcome, however, by administering a low dose of an isotopically labelled drug concomitantly with a therapeutic non-labelled oral dose. This technique eliminates pharmacokinetic issues on non-equivalent clearance as well as enabling the intravenous dose to be administered with a minimum of toxicology, the technique was first applied using stable-isotopes such as 13C and mass-spectrometry to distinguish the isotopes by mass difference. More recently, 14C labelled drugs are administered intravenously and accelerator mass spectrometry used to measure the isotopically labelled drug along with mass spectrometry for the unlabelled drug, in all such cases, to conduct an absolute bioavailability study requires that the drug be given intravenously. Intravenous administration of a drug can provide valuable information on the fundamental pharmacokinetic parameters of volume of distribution
37.
Traditional Chinese medicine
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It is primarily used as a complementary alternative medicine approach. TCM is widely used in China and is becoming prevalent in Europe. One of the tenets of TCM holds that the bodys vital energy circulates through channels, called meridians. Concepts of the body and of disease used in TCM reflect its ancient origins and its emphasis on dynamic processes over material structure, scientific investigation has not found histological or physiological evidence for traditional Chinese concepts such as qi, meridians, and acupuncture points. The TCM theory and practice are not based upon scientific knowledge, the effectiveness of Chinese herbal medicine remains poorly researched and documented. There are concerns over a number of toxic plants, animal parts. There are also concerns over illegal trade and transport of endangered species including rhinoceroses and tigers, a review of cost-effectiveness research for TCM found that studies had low levels of evidence, but so far have not shown benefit outcomes. Pharmaceutical research has explored the potential for creating new drugs from traditional remedies, proponents propose that research has so far missed key features of the art of TCM, such as unknown interactions between various ingredients and complex interactive biological systems. The doctrines of Chinese medicine are rooted in such as the Yellow Emperors Inner Canon and the Treatise on Cold Damage, as well as in cosmological notions such as yin-yang. Starting in the 1950s, these precepts were standardized in the Peoples Republic of China, including attempts to integrate them with modern notions of anatomy, in the 1950s, the Chinese government promoted a systematized form of TCM. TCMs view of the body places little emphasis on anatomical structures, while health is perceived as the harmonious interaction of these entities and the outside world, disease is interpreted as a disharmony in interaction. Traces of therapeutic activities in China date from the Shang dynasty, which Shang elites usually attributed to curses sent by their ancestors. There is no evidence that the Shang nobility used herbal remedies, according to a 2006 overview, the Documentation of Chinese materia medica dates back to around 1,100 BC when only dozens of drugs were first described. By the end of the 16th century, the number of drugs documented had reached close to 1,900, and by the end of the last century, published records of CMM had reached 12,800 drugs. Stone and bone found in ancient tombs led Joseph Needham to speculate that acupuncture might have been carried out in the Shang dynasty. The earliest evidence for acupuncture in this sense dates to the second or first century BC, the Yellow Emperors Inner Canon, the oldest received work of Chinese medical theory, was compiled around the first century BC on the basis of shorter texts from different medical lineages. It was also one of the first books in which the doctrines of Yinyang. The Treatise on Cold Damage Disorders and Miscellaneous Illnesses was collated by Zhang Zhongjing sometime between 196 and 220 CE, at the end of the Han dynasty
38.
Angelica sinensis
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Angelica sinensis, commonly known as dong quai or female ginseng is a herb from the family Apiaceae, indigenous to China. Angelica sinensis grows in high altitude mountains in China, Japan. The yellowish brown root of the plant is harvested in fall and is a well-known Chinese medicine used over thousands of years, the dong quai means that a husband shall return back to his wife, which is implicitly said to help womens sexual health. Dong quai is used for menopause vasomotor symptoms such as hot flashes, however, a randomized, double blind, placebo-controlled clinical trial showed that dong quai was no more effective than placebo. Potential anti-osteoporotic effects of dong quai independent of any estrogen mechanism were evaluated in rat models which showed that the extract of A. sinensis may prevent the bone loss, however, more high quality human evidence is needed to confirm same anti-osteoporotic effects of dong quai in humans. Dong quai contains a compound called butylidenephthalide which has antispasmodic activity in vitro. However, this claim lacks evidence of effectiveness in clinical trials. In an animal study, Dong quai also induced hair growth via the Inhibition of Apoptosis Signaling, overall, the U. S. National Library of Medicine states that more evidence is needed to rate the effectiveness of dong quai for most uses. There is evidence that A. sinensis may affect the muscles of the uterus, women who are pregnant or planning on becoming pregnant should not use A. sinensis, because it may induce a miscarriage. Taking A. sinensis can cause skin to become sensitive to the sun. One case of gynaecomastia has been reported following consumption of dong quai root powder pills, large and prolonged doses of the plant is not advised as it contains compounds that are considered carcinogenic. A. sinensis may increase the anticoagulant effects of the drug warfarin, the plants chemical constituents include phytosterols, polysaccharides, ligustilit, b-butyl phtalit, cnidilit, isoenidilit, p-cymen, ferulate, and flavonoids. When isolated from the plant, one of the chemicals, angelica polysaccharide sulfate, has in vitro antioxidant activity. Angelica Chinese herbology Scutellaria baicalensis Eleutherococcus senticosus or Siberian ginseng Wang, Kaiping, Cao, Peng, Shui, Weizhi, Yang, Qiuxiang, Tang, Zhuohong, Zhang, Yu. Jung, S. M. Schumacher, H. R. Kim, H. Kim, M. Lee, S. H. Pessler, reduction of Urate Crystal-Induced Inflammation by Root Extracts from Traditional Oriental Medicinal Plants, Elevation of Prostaglandin D2 Levels. - Considers anti-inflammatory properties of dried roots from the species Angelica sinensis, Acanthopanax senticosus, media related to Angelica sinensis at Wikimedia Commons Angelica sinensis List of Chemicals Ontario Ministry of Agriculture and Food Angelica Sinensis Diels. Medicinal Plant Images Database 當歸, Dang Gui, Chinese Angelica Chinese Medicine Specimen Database
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