The Fifth Avenue/53rd Street station is a station on the IND Queens Boulevard Line of the New York City Subway. Located at the intersection of Fifth Avenue and 53rd Street in Manhattan, it is served by the E train at all times and the M train weekdays except late nights.

The IND Queens Boulevard Line, sometimes abbreviated as QBL, is a line of the B Division of the New York City Subway in Manhattan and Queens, New York City, United States. The line, which is underground throughout its entire route, contains 23 stations. The core section between 50th Street in Hell's Kitchen, Manhattan, and 169th Street in Jamaica, Queens, was built by the Independent Subway System (IND) in stages between 1933 and 1940, with the Jamaica–179th Street terminus opening in 1950. As of 2015, it is among the system's busiest lines, with a weekday ridership of over 460,000 people.