Fifth Avenue is one of the longest streets in Pittsburgh, Pennsylvania, United States. It begins downtown and moves eastward for over five miles (9 km). Fifth Avenue passes by the Carlow University, the Cathedral of Learning and other buildings of the University of Pittsburgh, then forms the borders between Shadyside on the north and Squirrel Hill and Point Breeze to the south. Finally, after passing Chatham University, The Ellis School, and Mellon Park, it turns north and forms the border between Larimer on the west and North Point Breeze and Homewood (Pittsburgh) on the east. At the intersection with Frankstown Avenue its name becomes Washington Boulevard and descends a branch of Negley Run to meet Allegheny River Boulevard near the Highland Park Bridge.

Forbes Avenue is one of the longest streets in Pittsburgh, Pennsylvania, United States. It runs along an east–west route for a length of approximately 7 mi (11 km).