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File:Steroidogenesis.svg

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Summary[edit]

Description
English: Enzymes, their cellular location, substrates and products in human steroidogenesis.

Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids.

White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see Wikipedia:structural formula.

HSD: Hydroxysteroid dehydrogenase

References:

  • Boron WF, Boulpaep EL () Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3.
  • For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013).
There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.

Further reading:

  • Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology 43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824.
  • Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews 25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024.

See also:

Polski: Enzymy biorące udział w steroidogenezie.

Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie.

HSD: Dehydrogenaza hydroksysteroidu
Русский: Ферменты, участвующие в стероидогенезе человека, с указанием субстратов и продуктов, а также локализации их активности. Происходящие изменения в структуре молекул отмечены белыми кружочками. По сборнику "Медицинская физиология" (Walter F. Boron, Emile L. Boulpaep, 2003 год).
日本語: この図はヒトのステロイドホルモン生成における酵素と酵素が存在する細胞器官、基質ならびに生成物の全体図である。またこの図は(コレステロールから)プロゲステロン、鉱質コルチコイド、糖質コルチコイド、そしてアンドロゲンおよびエストロゲンに至る主要なステロイドを記述している。

図に示すとおりそれぞれ(生合成の過程で)オーバーラップするものである。 図中、白い円で囲んだところは基質と比較した分子構造の変化した箇所を示す。

なお、HSD は、ヒドロキシステロイドデヒドロゲナーゼを表す。
Date
Source Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20024436.
Author David Richfield (User:Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr.

In external use, this diagram may be cited as:

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Evolution[edit]

A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.

1. (March 2007) Previous image by Stannered.
4. (August 2008) Vector (.svg) version by Slashme.
2. (July 2007) Molecular structures added by Hoffmeier and Settersr.
5. (March 2009) Expansion, grouping, addition of enzyme localization, numbering of cholesterol and coloring by Mikael Häggström.
3. (November 2007) Organization and addition of enzymes by Mikael Häggström.

Licensing[edit]

GNU head Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.
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File history

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(newest | oldest) View (newer 10 | ) (10 | 20 | 50 | 100 | 250 | 500)
Date/TimeThumbnailDimensionsUserComment
current15:12, 13 March 2013Thumbnail for version as of 15:12, 13 March 20131,245 × 1,105 (133 KB)SlashmeRemoved arrow from Corticosterone to Cortisol via CYP17A1 (see http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140 )
16:15, 9 July 2012Thumbnail for version as of 16:15, 9 July 20121,245 × 1,105 (133 KB)Mikael HäggströmAddition and correction of stereochemistries at positions 11 and 17.
04:24, 9 July 2012Thumbnail for version as of 04:24, 9 July 20121,245 × 1,105 (127 KB)Mikael HäggströmAdded stereochemistries, removed redundant white circle at cortisol, renamed 21-alpha hydroxylase to simply 21-hydroxylase.
05:15, 13 December 2011Thumbnail for version as of 05:15, 13 December 20111,245 × 1,105 (114 KB)SlashmeAlign some text and arrows for neatness' sake.
04:56, 13 December 2011Thumbnail for version as of 04:56, 13 December 20111,245 × 1,105 (114 KB)SlashmeFixed reaction scheme: corticosterone doesn't go to cortisol! Karl and Lindie, why didn't you fix it when you first found out? Tsk tsk.
12:58, 8 May 2010Thumbnail for version as of 12:58, 8 May 20101,245 × 1,105 (114 KB)Mikael Häggströmminor move of 5-a-reductase
12:56, 8 May 2010Thumbnail for version as of 12:56, 8 May 20101,245 × 1,105 (114 KB)Mikael Häggströmminor renaming of 3-beta-HSD
06:46, 24 April 2010Thumbnail for version as of 06:46, 24 April 20101,245 × 1,105 (114 KB)Mikael HäggströmMoved name out of molecular structure
11:53, 13 May 2009Thumbnail for version as of 11:53, 13 May 20091,245 × 1,105 (114 KB)Mikael HäggströmMoved misplaced nr 6 on cholesterol
11:16, 8 April 2009Thumbnail for version as of 11:16, 8 April 20091,245 × 1,105 (114 KB)Mikael HäggströmCorrected groups. It's cortisol that has mineralocorticoid effects (requiring 11 hydroxysteroid dehydrogenase to be present in the kidneys not to be overwhelmed by this effect), and not the opposite.
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