Flavin containing monooxygenase 1

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
FMO1
Identifiers
AliasesFMO1, flavin containing monooxygenase 1
External IDsMGI: 1310002 HomoloGene: 55520 GeneCards: FMO1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for FMO1
Genomic location for FMO1
Band1q24.3Start171,248,471 bp[1]
End171,285,978 bp[1]
RNA expression pattern
PBB GE FMO1 205666 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282692
NM_001282693
NM_001282694
NM_002021

NM_010231
NM_001330291
NM_001330318

RefSeq (protein)

NP_001269621
NP_001269622
NP_001269623
NP_002012

NP_001317220
NP_001317247
NP_034361

Location (UCSC)Chr 1: 171.25 – 171.29 MbChr 1: 162.83 – 162.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that in humans is encoded by the FMO1 gene.[5]

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in xenobiotics such as pesticides and drugs.[5]

References[edit]

Further reading[edit]