Florida's 2nd congressional district is a congressional district in the U.S. state of Florida. The district consists of the eastern part of the Florida Panhandle along with much of the Big Bend region along the Emerald Coast. It straddles both the Eastern and Central time zones. It includes Tallahassee, the state capital, and Panama City. With 49% of its residents living in rural areas, it is the least urbanized district in the state, and voters are generally conservative. The district is represented by Republican Neal Dunn of Panama City.

Tallahassee is the capital city of the U.S. state of Florida. It is the county seat and only incorporated municipality in Leon County. Tallahassee became the capital of Florida, then the Florida Territory, in 1824. In 2022, the population was 201,731, making it the eighth-most populous city in the state of Florida. The population of the Tallahassee metropolitan area was 390,992 as of 2022. Tallahassee is the largest city in the Florida Big Bend and Florida Panhandle region, and the main center for trade and agriculture in the Florida Big Bend and Southwest Georgia regions.