Flunitrazepam known as Rohypnol among other names, is a benzodiazepine used to treat severe insomnia and assist with anesthesia. As with other hypnotics, flunitrazepam has been advised to be prescribed only on a short-term basis or by those with chronic insomnia on an occasional basis, it was patented in 1962 and came into medical use in 1974. Flunitrazepam has been referred to as a date rape drug, though the percentage of reported rape cases in which it is involved is small. In countries where this drug is used, it is used for treatment of sleeping problems, in some countries to begin anesthesia; these were the uses for which it was studied. Adverse effects of flunitrazepam include dependence, both psychological; because of the latter, flunitrazepam is used in suicide. When used in pregnancy, it might cause hypotonia. Flunitrazepam as with other benzodiazepines can lead to drug dependence and benzodiazepine withdrawal syndrome. Discontinuation may result in the appearance of withdrawal symptoms.
Abrupt withdrawal may lead to a benzodiazepine withdrawal syndrome characterised by seizures, psychosis and anxiety. Rebound insomnia, worse than baseline insomnia occurs after discontinuation of flunitrazepam from short-term single nightly dose therapy. Flunitrazepam may cause a paradoxical reaction in some individuals causing symptoms including anxiety, agitation, disinhibition, loss of impulse control, violent behavior, convulsions. Paradoxical adverse effects may lead to criminal behaviour. Benzodiazepines such as flunitrazepam are lipophilic and penetrate membranes and, therefore cross over into the placenta with significant uptake of the drug. Use of benzodiazepines including flunitrazepam in late pregnancy high doses, may result in hypotonia known as floppy baby syndrome. Flunitrazepam impairs cognitive functions; this may appear as lack of concentration and anterograde amnesia. It can be described as a hangover-like effect, it impairs psychomotor functions similar to other benzodiazepines and nonbenzodiazepine hypnotic drugs.
The combination with alcohol increases these impairments. Partial, but incomplete tolerance develops to these impairments. Other adverse effects include: Slurred speech Gastrointestinal disturbances, lasting 12 or more hours Vomiting Respiratory depression in higher doses Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, in alcohol- or drug-dependent individuals, in individuals with comorbid psychiatric disorders. Impairment of driving skills with a resultant increased risk of road traffic accidents is the most important adverse effect; this side-effect is not unique to flunitrazepam but occurs with other hypnotic drugs. Flunitrazepam seems to have a high risk of road traffic accidents compared to other hypnotic drugs. Extreme caution should be exercised by drivers after taking flunitrazepam; the use of flunitrazepam in combination with alcoholic beverages synergizes the adverse effects, can lead to toxicity and death. Flunitrazepam is a drug, involved in drug intoxication, including overdose.
Overdose of flunitrazepam may result in impairment of balance or speech. This may progress in severe overdoses to respiratory depression or coma and death; the risk of overdose is increased if flunitrazepam is taken in combination with CNS depressants such as ethanol and opioids. Flunitrazepam overdose responds to the benzodiazepine receptor antagonist flumazenil, which thus can be used as a treatment; as of 2016, blood tests can identify flunitrazepam at concentrations of as low as 4 ng/ml. For urine samples, metabolites can be identified 60 hours to 28 days, depending on the dose and analytical method used. Hair and saliva can be analyzed. Flunitrazepam can be measured in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired driving arrest, or assist in a medicolegal death investigation. Blood or plasma flunitrazepam concentrations are in a range of 5–20 μg/L in persons receiving the drug therapeutically as a nighttime hypnotic, 10–50 μg/L in those arrested for impaired driving and 100–1000 μg/L in victims of acute fatal overdosage.
Urine is the preferred specimen for routine drug abuse monitoring purposes. The presence of 7-aminoflunitrazepam, a pharmacologically-active metabolite and in vitro degradation product, is useful for confirmation of flunitrazepam ingestion. In postmortem specimens, the parent drug may have been degraded over time to 7-aminoflunitrazepam. Other metabolites include 3-hydroxydesmethylflunitrazepam; the main pharmacological effects of flunitrazepam are the enhancement of GABA at various GABA receptors. While 80% of flunitrazepam, taken orally is absorbed, bioavailability in suppository form is closer to 50%. Flunitrazepam has a long half-life of 18–26 hours, which means that flunitrazepam's effects after nighttime administration persist throughout the next day. Flunitrazepam is metabolised hepatically via oxidative pathways; the enzyme CYP3A4 is the main enzyme in its phase 1 metabolism in human liver microsomes. Flunitrazepam is classed as a nitro-benzodiazepine, it is the fluorinated N-methyl
Quincy Howe was an American journalist, best known for his CBS radio broadcasts during World War II. Born in Boston, Massachusetts, he was the son of sister of Helen Howe, he was a 1921 graduate of Harvard University. Howe served as director of the American Civil Liberties Union before the Second World War, as chief editor at Simon & Schuster from 1935 to 1942, he once said that life began for him in 1939, when he began to broadcast news and commentary on WQXR radio in New York City. Howe joined CBS in June 1942, doing the opening news summary on the radio network's The World Today newscast, he left CBS in 1947 to join ABC. In the fall of 1955, he hosted four episodes of the 26-week prime time series Medical Horizons on ABC before he was replaced in that capacity by Don Goddard. In the early 1950s, Howe was an associate professor of journalism and communications at the University of Illinois. Howe moderated the fourth and final Kennedy/Nixon debate on October 21, 1960. Howe retired from broadcasting in 1974.
The Handelsblatt is a leading German-language business newspaper published in Düsseldorf by Verlagsgruppe Handelsblatt. Handelsblatt was established in 1946. Since 2016, its editor-in-chief is Sven Afhüppe, its publisher, Verlagsgruppe Handelsblatt publishes the weekly business magazine Wirtschaftswoche of which the editor-in-chief is Miriam Meckel since 2014. Handelsblatt's headquarters are in Düsseldorf. Since September 2005 Handelsblatt has been offering an online lexicon called WirtschaftsWiki which features definitions of terms used in economics and politics; the database can be modified by any registered user. In September 2006 Handelsblatt ranked all economists working in Germany and the German-speaking part of Switzerland; the paper is published in compact format. In 2009, Dieter von Holtzbrinck bought Der Tagesspiegel, Handelsblatt and "WirtschaftsWoche" from the Georg von Holtzbrinck Publishing Group. Handelsblatt had a circulation of 127,546 daily copies in 2018. An English-language digital edition was launched in 2014, called Handelsblatt Global Edition, which aimed to reach an international audience interested in German business and finance news.
It was published five days a week from its editorial office in Berlin with editor-in-chief, Kevin O’Brien at the helm. In 2017, under a new editor-in-chief, Andreas Kluth, the publication avoided the direct translation of German-language articles and instead worked through differences between German and Anglophone journalistic traditions to add details that English readers were accustomed to; the site was renamed Handelsblatt Today in 2018, unable to create a business model and reach a substantial audience to generate revenue, Kluth announced that publication would cease on 27 February 2019. Handelsblatt.com Handelsblatt Today
"Over My Head" is a soft rock song performed by British/American music group Fleetwood Mac. The song was written by group keyboardist/vocalist Christine McVie, it was the band's first single to reach the Billboard Hot 100 since "Oh Well", ending a six-year dry spell on American charts. In the U. S. Reprise Records selected "Over My Head" as the lead single from the 1975 LP Fleetwood Mac, a decision that surprised the band, who believed that the song was the "least track on Fleetwood Mac to be released as a single." It reached #20 on the Billboard Hot 100 chart in early 1976. The single's success helped. Christine McVie composed the song using a portable Hohner electric piano in a small apartment in Malibu, where she and then-husband John McVie resided after completing a concert tour to promote the previous album, Heroes Are Hard to Find; the original rhythm track consisted of drums and a Dobro. Other instruments were added to embellish the song, including McVie's Vox Continental organ; the 45 RPM single version of the song released for radio airplay was a remixed, edited version that differed from the mix on the Fleetwood Mac album.
The single version is distinguished by a cold start, louder guitar strums in the choruses and less ensemble vocal work overall. In addition, whereas the single version fades during its three-bar instrumental outro, the album version tape-loops it to six bars upon fade-out. While the album version has a wide stereo spectrum, the single version is mixed narrowly with stereo reverberation effects on some bongo passages and select guitar flourishes, it is this remixed/edited version, included on the compilation album The Very Best of Fleetwood Mac. The single version is available as a bonus track on the 2004 remastered CD release of the Fleetwood Mac album. Mick Fleetwood – drums, shaker John McVie – bass guitar Christine McVie – Vox Continental organ, electric piano, lead vocals Lindsey Buckingham – electric and acoustic guitars, backing vocals Stevie Nicks – backing vocals The Great Rock Discography. Martin C. Strong. Page 378. ISBN 1-84195-312-1 Lyrics of this song at MetroLyrics
Wolfgang Mayrhofer is an Austrian competitive sailor and Olympic silver medalist as well as professor of management at WU in Vienna. He won a silver medal in the Finn class at the 1980 Summer Olympics in Moscow. Mayrhofer is sailing since the age of 5. From 1963-1973 he sailed Optimist, the most popular single-handed boat for children below the age of 15. Sailing OK-Dinghy from 1974-1976 and Finn-Dinghy from 1976-1983. In OK and Finn several times national champion. In the Finn-class European vice-champion in Finn in 1979. Since 1983 hobby sailing with occasional dinghy and big-boat racing, he has his own company, Championships where he uses sail boats as a unique field of experience and conducts trainings for middle and top managers, focusing on team building, team development and communication. At the professional level, Wolfgang Mayrhofer is Professor of Management and Organisational Behaviour at the Institute of Organisation Studies and Organisational Behaviour, Department of Management, WU, Austria.
He has held research and teaching positions at the University of Paderborn, at Dresden University of Technology, after receiving his diploma and doctoral degrees in Business Administration from WU. He conducts research in the area of comparative international human resource management and leadership, work careers, systems theory and management and has received several national and international rewards for outstanding research and service to the academic community, he has had many international teaching assignments, among others at Copenhagen Business School, the United Nations, ESADE, Estonian Business School, Hertie School of Governance, INCAE, Rotterdam School of Management, Universidad Carlos III and University of Istanbul and consults to both private and public sector organisations, with an emphasis on leadership and self-development by outdoor training/sailing. Wolfgang Mayrhofer is a member of the editorial/advisory editorial board of the Journal for Managerial Psychology, the Journal for Cross-Cultural Competence and Management, the Journal of the International Society for Research in Healthcare Financial Management, the Journal of Management Spirituality and Religion, Management Revue, Zeitschrift für Personalforschung, The Jordanian Journal of Administrative Sciences, the ESADE-DEUSTO Series ‘Managing people in 21st century organisations’ and a corresponding member of Journal for East European Management Studies.
He is an associate at the Centre for Research into the Management of Expatriation, Cranfield, UK, a research fellow at the Centre for Global Workforce Strategy, Simon Fraser University, member of the academic advisory board of AHRMIO, the Association of Human Resource Management in International Organisations and an appointed visiting professor at Henley Management College, UK. He has four children, three daughters and one son, he has authored and co-authored more than 100 book chapters and about 60 peer reviewed articles which have been published, among others, in Career Development International, Employee Relations, Human Relations, Human Resource Management Journal, Human Resource Management Review, International Journal for Human Resource Management, International Studies of Management & Organization, International Executive, Journal of Managerial Psychology, Journal of Occupational and Organisational Psychology, Management Revue, Organisation Studies, Die Betriebswirtschaft, Zeitschrift für Personalforschung and Personal.
Wolfgang Mayrhofer has authored, co-authored and co-edited 27 books, among them most recently: Brewster, C. & Mayrhofer, W.. 2012. Handbook Of Research On Comparative Human Resource Management. Cheltenham: Edward Elgar. 2012. Careers Around the World. Individual and Contextual Perspectives. New York, Oxon: Routledge Mayrhofer, W. Meyer, M. & Titscher, S.. 2010. Praxis der Organisationsanalyse. Anwendungsfelder und Methoden. Wien: Facultas wuv. Konzepte und Methoden, Wien et al.: facultas wuv UTB 2008, with S. Titscher and M. Meyer. Erten, U. Seebacher and G. Strunk. H. Larsen, London: Routledge 2006. Neue Koordinations- und Steuerungsformen und ihre Konsequenzen für Nonprofit-Organisationen - eine systemtheoretische Analyse, edited with. A. Zauner, P. Heimerl, W. Mayrhofer, M. Meyer, A. Nachbagauer, S. Praschak and H. Schmidtmayr, Bern: Haupt 2006. Evans, Hilary. "Wolfgang Mayrhofer". Olympics at Sports-Reference.com. Sports Reference LLC. Retrieved 12 February 2011. Homepage: http://www.wu.ac.at/ivm/team/wiss_ma/w_mayrhofer
Sir Basil Alexander Talbot McFarland, 2nd Baronet, CBE, ERD was a Northern Irish soldier and Ulster Unionist Party politician. The son of Sir John McFarland, 1st Baronet, he was a businessman, a Senator of Northern Ireland, Mayor of Derry, Lord Lieutenant of the County Borough of Londonderry and an Ireland rugby union international, he succeeded to his father's title in 1926. Born in County Londonderry, Sir Basil was educated at Bedford School and in Brussels and Neuwied-on-Rhine, Germany. Sir Basil was High Sheriff of the City of Londonderry, 1930–1938 and 1952, High Sheriff of County Londonderry, 1952, he served in 1918 with the Artists Rifles, in the Second World War served overseas in North Africa, with the 9th Londonderry HAA Regiment and was Mentioned in Dispatches. He was Commanding Officer of the Londonderry City Battalion of the Home Guard, Chairman of the Territorial Army and Auxiliary Force Association, 1947–1962, a member of its national Council. McFarland was Hon. Colonel of the 9th Londonderry HAA Regiment of the Royal Artillery, President of the Northern Ireland TA and Volunteer Reserve Association, 1968–1971.
He was a Commissioner of Irish Lights, an original member of the Northern Ireland Unemployment Assistance Board, a Senator in the Parliament of Northern Ireland, 1945–1950, a member of the Northern Ireland Air Advisory Council, 1946–1965, Chairman of the Londonderry Port and Harbour Commissioners, 1952–1967, a member of the London Midland Area Board of the British Transport Commission, 1955–1961, a trustee of Magee University College, Derry, 1962–1965. His directorships and business interests included directorships of the Belfast Banking Company Ltd, 1930–1970, the Belfast Bank Executors Trustee Company, the Donegal Railway Company, a local directorship of the Commercial Union Assurance Co. and the chairmanship of Sir Alfred McAlpine & Son Ltd, the Londonderry and Lough Swilly Railway Company, Lanes Ltd, Lanes Ltd, Lanes Ltd, John W. Corbett & Sons, R. C. Malseed & Co. Ltd, Alexander Thompson & Co. Ltd and the Londonderry Gaslight Co. Sir Basil was married to Annie Kathleen Henderson, daughter of Andrew Henderson JP of Parkville, Belfast.
Sir Basil had two children, including Sir John McFarland, 3rd Baronet, who lives at Dunmore House in Carrigans in the east of County Donegal. His second marriage took place in 1955 to Mary Eleanor Dougan, he lived at a small mansion that overlooks the Strand Road in the City of Derry. He was Given the Freedom of the City of Derry in 1944. Proni.gov.uk