Fluorothymidine F-18

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Fluorothymidine F-18
Clinical data
Synonyms [18F]Fluorothymidine; 18F-3'-Fluoro-3'-deoxythymidine; 18F-FLT
CAS Number
Chemical and physical data
Formula C10H13FN2O4
Molar mass 244.22 g·mol−1
3D model (JSmol)

Fluorothymidine F-18 (FLT) is a tumor-specific PET tracer and radiopharmaceutical. It is a version of alovudine in which the fluorine atom has been isotopically labeled as fluorine-18. FLT is suitable for monitoring how tumors respond to cytostatic therapy. FLT accumulates in proliferating cells where it indicates the activity of the enzyme thymidine kinase. Cell division can be characterized by the activity of that enzyme. FLT is phosphorylated as though it were thymidine, and is subsequently incorporated into DNA. Thymidine is essential for DNA replication. Considering that FLT lacks a 3′-hydroxy group, transcription of DNA is impeded following incorporating of FLT. FLT indicates changes in tumor cell proliferation by tracking the restoration of nucleosides from degenerated DNA.[1]


  1. ^ Wagner, M; Seitz, U; Buck, A; Neumaier, B; Schultheiss, S; Bangerter, M; Bommer, M; Leithäuser, F; Wawra, E; Munzert, G; Reske, S. N. (2003). "3'-18Ffluoro-3'-deoxythymidine (18F-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-Cell lymphoma model and in the human disease" (PDF). Cancer Research. 63 (10): 2681–7. PMID 12750297.