Folch solution

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Folch solution is a solution containing chloroform and methanol, usually in a 2:1 (vol/vol) ratio.[1] One of its uses is in separating polar from nonpolar compounds, for example separating nonpolar lipids from polar proteins and carbohydrates in blood serum.


  1. ^ Folch, J.; Lees, M.; Sloan Stanley, G.H. (May 1, 1957). "A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues". Journal of Biological Chemistry. 226: 497–509.