Formyltetrahydrofolate deformylase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
formyltetrahydrofolate deformylase
Identifiers
EC number3.5.1.10
CAS number9025-08-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a formyltetrahydrofolate deformylase (EC 3.5.1.10) is an enzyme that catalyzes the chemical reaction

10-formyltetrahydrofolate + H2O formate + tetrahydrofolate

Thus, the two substrates of this enzyme are 10-formyltetrahydrofolate and H2O, whereas its two products are formate and tetrahydrofolate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 10-formyltetrahydrofolate amidohydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.

References[edit]

  • Huennekens FM (1957). "Enzymatic deacylation of N10-formyltetrahydrofolic acid". Fed. Proc. 16: 199.