Fort Saint Joseph was a fort established on land granted to the Jesuits by King Louis XIV; it was located on what is now the south side of the present-day town of Niles, Michigan. Père Claude-Jean Allouez established the Mission de Saint-Joseph in the 1680s. Allouez ministered to the local Native Americans, who were primarily Odawa and Ojibwe.

Niles is a city in Berrien and Cass counties in the U.S. state of Michigan, near the Indiana state line city of South Bend. The population was 11,988 according to the 2020 census. It is the larger, by population, of the two principal cities in the Niles-Benton Harbor metropolitan area, an area with 153,797 people.