Francesco Barberini, iuniore was an Italian Cardinal of the family of Pope Urban VIII (1623–1644) and of the Princes of Palestrina.

Palestrina is a modern Italian city and comune (municipality) with a population of about 22,000, in Lazio, about 35 kilometres east of Rome. It is connected to the latter by the Via Prenestina. It is built upon the ruins of the ancient city of Praeneste.