Frederick V, Margrave of Baden-Durlach was a German nobleman, who ruled as margrave of Baden-Durlach from 1622 to his death. He was succeeded by his son Frederick VI, Margrave of Baden-Durlach.

The Margraviate of Baden-Durlach was an early modern territory of the Holy Roman Empire, in the upper Rhine valley, which existed from 1535 to 1771. It was formed when the Margraviate of Baden was split between the sons of Margrave Christopher I and was named for its capital, Durlach. The other half of the territory became the Margraviate of Baden-Baden, located between the two halves of Baden-Durlach. Baden-Durlach became Lutheran during the Protestant Reformation, unlike Baden-Baden, which remained Catholic. Baden-Durlach occupied Baden-Baden from 1594 to 1622, but was driven out after being defeated at the Battle of Wimpfen, during the Thirty Years' War (1618–1648). The territory was ravaged during the Nine Years' War (1688–1697). Following the extinction of the Baden-Baden line in 1771, the Baden-Durlach inherited their territories and reunited the Margraviate of Baden. The reunified territory was caught up in the French Revolutionary and Napoleonic Wars, emerging in 1806 as the Grand Duchy of Baden.