GANC

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
GANC
Identifiers
AliasesGANC, glucosidase alpha, neutral C
External IDsMGI: 1923301 HomoloGene: 25627 GeneCards: GANC
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for GANC
Genomic location for GANC
Band15q15.1Start42,273,233 bp[1]
End42,356,935 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198141
NM_001301409
NM_001301410

NM_172672

RefSeq (protein)

NP_001288338
NP_001288339
NP_937784

NP_766260

Location (UCSC)Chr 15: 42.27 – 42.36 MbChr 2: 120.4 – 120.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene.[5][6][7]

Function[edit]

Glycoside hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214013 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062646 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Martiniuk F, Hirschhorn R, Smith M (Oct 1980). "Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15". Cytogenetics and Cell Genetics. 27 (2-3): 168–75. doi:10.1159/000131478. PMID 6995030. 
  6. ^ Hirschhorn R, Huie ML, Kasper JS (Oct 2002). "Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13642–6. doi:10.1073/pnas.202383599. PMC 129728Freely accessible. PMID 12370436. 
  7. ^ a b "Entrez Gene: GANC glucosidase, alpha; neutral C". 

Further reading[edit]