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Gales Brewery

George Gale & Co. Ltd was a Hampshire brewery with a distinctive range of bitter beers. Founded in 1847 it was bought by the London brewers, Fullers of Chiswick in 2005; the brewery was closed in 2006 with production transferred to Chiswick. Established in 1847 Gales Brewery was an old brewery situated in Horndean, on the edge of Waterlooville, near Portsmouth in Hampshire, England, it made the newer Gales Bitter. It took its water from its own well situated under the brewery, fed from the South Downs, the yeast and'liquor', coupled with the local brewing style, produced beers with a sparse head, quite dark in colour. In late 2005 Fuller's Brewery bought Gales for £92 million, it raised fears as to the future of Gales Horndean brewery and some of its beers, the Campaign for Real Ale launched a campaign to encourage Fuller's to continue production of the full Gales line at Horndean. However, in January 2006, Fuller's began cutting jobs at the Horndean brewery, it was announced on 27 February 2006 that the brewery would close at the end of March 2006, although distribution and warehousing would continue in the area.

At that point, production of the Gales brands moved to Fuller's Griffin Brewery in Chiswick, with the exception of Gales Bitter, discontinued. As of 2017, most of the brewery site has been replaced with retail shops; the main tower remains standing and was converted alongside the construction of new buildings into apartments. HSB = The flagship brew of the brewery. Brewed to 4.8% Butser = A medium strength bitter with a pleasant lightness of touch and good balance and was known as BBB until 1991. Became unique to Fuller's pubs in the south after the takeover or was available as a seasonal at other Fuller's Pubs until 2009, when all the remaining Gales branded ales sold were discontinued. Brewed to 3.4% Prize Old Ale = A range of ales with a unique, fruity flavour from a prolonged maturation and a special brewing process. The last Prize Old Ale was discontinued. All of the Prize Old Ales are brewed to 9.0%. Festival Mild = Was produced for a beer festival held by the North Hants and Surrey division of CAMRA in the 1990s, went on to be sold publicly, winning CAMRA beer awards.

The ale became unique to Fuller's pubs in the south after the takeover or was available as a seasonal at other Fuller's Pubs until 2009, when all the remaining Gales branded ales sold were discontinued. This beer is brewed to 4.8%. Seafarers Ale = Was developed in 2009 as a partnership with Seafarers, the leading maritime charity. Brewed to 3.6% or 4.2%. Spring Sprinter = Introduced in 2011, it is a light zesty ale available every spring. Cask only and brewed to 3.8%. Winter Brew = An winter themed ale with a similar taste to Prize Old Ale. Brewed to 4.2% Swing Low = An ale, brewed for the rugby season. Brewed to 3.8%. Summer Breeze = A bottle-exclusive classic, summer ale brewed for the summertime. Brewed to 3.8%. Gales Best Bitter = In the early 2000s, this beer was given a makeover, but was discontinued in 2006 due to it having a similar taste to Fuller's London Pride and outselling the latter. Brewed to 4.0%. Gales GB Gales Light Ale Other discontinued draught & keg beers *XXX Light Mild, *XXXD Dark Mild, *777 Keg Mild, *Gales Keg Bitter Other discontinued bottled beers *Nut Brown Last Drop = The last ale brewed at the Gales Brewery before its closure in 2006.

Gales Trafalgar 200 = Was first brewed in 2005 to celebrate the bicentenary of Nelson’s famous victory. Gales Clubhouse Bitter = Gales Crowning Glory = Was made to celebrate the Queen's Golden Jubilee in 2002. Gales Millennium Brew = Was made to celebrate the new millennium in 2000. Gales Conquest Ale Gales D-Day Ale Gales Silver Jubilee Ale = Was made to celebrate the Queen's Silver Jubilee in 1977 Gales Royal Wedding Ale = Was made to celebrate the 1981 Royal Wedding. Gales Portsmouth 800 Ale = Was made to celebrate the 800th anniversary of Portsmouth in 1994. Gales Golden Jubilee Ale = Was made to celebrate the Queen's Golden Jubilee in 2002. Gales Victory Ale Gales Vanguard Ale

MiR-206

MiR-206 is a microRNA that in humans is a member of the myomiR family which includes miR-1, miR-133, miR-208a/b among few others. As well as being regulated during the embryonic development of skeletal muscle, miR-206 is regulated by estradiol. C2C12 myoblast cells are used as a model for the study of cell differentiation in skeletal muscle. Furthermore, miR-206 is expressed in triple-negative breast tumors that grow independent of estradiol, miR-206 is a predictor of worse overall survival in breast cancer patients; the biogenesis of miR-206 is unique in that the primary mature transcript is generated from the 3p arm of the precursor hairpin rather than the 5p arm. MiR-206 has 12 additional family members, whereby the seed sequence is 100% conserved across all miRNAs within the family. Single nucleotide polymorphisms are present in the miRNA sequence, some of them with functional consequences, in the sense that the efficiency of miRNA binding to a cognate mRNA target is altered depending on a single nucleotide substitution.

In fact a number of studies have indicated that the canonical seed sequence of a miRNA is not longer the sole determinate in miRNA:mRNA pairing interactions, as mutations of residues outside the seed region alters binding efficacy. MiR-206 is of interest due to the continued detection of this miRNA in samples from those with type 2 diabetes and non-alcoholic fatty liver disease. In some studies the therapeutic delivery of miR-206 in a dietary obese mouse model resulted in reduced lipid and glucose production within the liver; the ability of miR-206 to facilitate insulin signaling and modulate lipogenesis indicates miR-206 may be a novel therapy for those with hyperglycemia

M18 Hellcat

The M18 Hellcat was an American tank destroyer of World War II used in the Korean War. It was the fastest U. S. armored fighting vehicle on the road. The speed was attained by keeping armor to a minimum, using the innovative Torqmatic automatic transmission, by equipping the light vehicle with the same main gun used on the much larger Sherman tank; the Hellcat was the most effective U. S. tank destroyer of World War II. It had a higher kill to loss ratio than any other tank or tank destroyer fielded by U. S. forces in World War II. When the Tank Destroyer Force was organized in 1941, their commander, Lieutenant Colonel Andrew Davis Bruce envisioned the units being equipped with something faster than a tank, with a better gun but less armor to allow for speed, he objected to the 3 inch M10 Gun Motor Carriage because it was too heavy and slow for his needs, on to the 90 mm M36 Gun Motor Carriage because it was an M10 with a bigger gun. The United States Ordnance Corps made several failed attempts to provide said vehicle using the weapons and technology available, including mounting the 3-inch gun on the fast M3 Light Tank chassis.

The M18 was the end product of a long line of research vehicles aimed at providing the desired machine. In December 1941, the Ordnance Department issued a requirement for the design of a fast tank destroyer using a Christie suspension, a Wright-Continental R-975 radial aircraft engine, a 37 mm gun. Two pilot vehicles were to be built. What became the M18 originated in Harley Earl's design studio, part of the Buick Motor Division of General Motors. Basic designs for other kinds of vehicles had originated from within the Ordnance Department. Buick's engineers used a torsion bar suspension. Though it weighed about 20 tons, the Hellcat was capable of traveling upwards of 45 mph, its power came from Wright R-975, a nine-cylinder, 350-to-400-horsepower radial aircraft engine, paired to a three-speed 900T Torqmatic automatic transmission. Changes to the specification mean that the first pilot – the 57 mm Gun Motor Carriage T49 – was built with the British QF 6-pounder gun instead of the 37 mm and a torsion bar suspension instead of the Christie suspension.

It was tested in 1942 but the army wanted a heavier gun – the same 75 mm gun M3 as used on the M4 Sherman medium tank. The T49 project was cancelled and the second pilot was built with the 75 mm gun as the 75 mm Gun Motor Carriage T67; this met approval, but in early 1943 the army requested a more powerful gun – the 76 mm gun M1 under development for the Sherman. Six pilot models – as the 76 mm Gun Motor Carriage T70 – were built with this gun; the trials of these models led to a new turret and changes to the hull front, but the design was otherwise accepted for production, which began in July 1943. Once developed, the Hellcat was tested in the same manner as passenger cars before and after it, at the General Motors Milford Proving Ground. Top speed testing was done on a paved, banked oval and ride quality tests were done over specially developed stretches of bumps; the M18 required tests of its ability to ford six feet of water, climb small walls, ram through structures. The first models of the tank destroyer were tested by the US Army's 704th Tank Destroyer Battalion.

The unit had been trained on the M3 Gun Motor Carriage. Despite its T70 prototypes requiring several improvements, the 704th had a "superlative" testing record, the unit was issued production Hellcats after many of their suggestions were integrated into the vehicle; the testing phase of the Hellcat proved that teamwork was an essential element of the new light tank destroyer units, replaced the fixed, rigid structure of other units with a much more flexible command structure that allowed adapting to more complicated tasks. The M18's new design incorporated several labor saving and innovative maintenance features, it used the same Wright R975 engine as the Sherman tank, but turned 90 degrees in order to have a lower profile. The unitized drivetrain was much easier to maintain, as it was mounted on rails equipped with steel rollers that allowed maintenance crews to disconnect it from the transmission, roll it out onto the lowered engine rear cover using rails, service it, reconnect it to the transmission.

The transmission could be removed and rolled out onto a front deck plate to facilitate quick inspection and repairs. In contrast to the M10 and M36, tank destroyers, which used the heavy chassis of the M4 Sherman, the M18 Hellcat was designed from the start to be a fast tank destroyer; as a result, it was smaller, more comfortable, faster, but carried the same gun as the Sherman 76 mm models. The M18 carried a five-man crew, consisting of a commander, loader and assistant driver. 45 rounds of main gun ammunition were carried, 18 in each sponson. An M2 Browning machine gun with 800 rounds of ammunition was provided on a flexible ring mount for use against enemy aircraft and infantry; the armor of the M18 Hellcat was quite light to facilitate its high speed, provided little protection from the most used German antitank weapons. At the time thickly armored Allied tanks were unable to withstand most German antitank weapons, so reduction of armor had little negative effect on survival compared to most other Allied tanks of the period.

The lower hull armor was 12.7 mm thick all around, vertical on the sides, but sloped at 35 degrees from the vertic

Edouard Drouhet

Edouard Drouhet was a physician and medical mycologist who played a key role in understanding how anti-fungal agents such as ketoconazole and amphotericin-B can be used as therapeutic treatments in humans with superficial or deep-seated mycoses. He was one of the founding members in the International Society of Human and Animal Mycology and the French Society of Medical Mycology. After Edouard Drouhet's death, Edouard Drouhet is commemorated at the European Confederation of Medical Mycology by having a lecture and a medal dedicated in his name. Drouhet was born in Bârlad, Romania into a family of French descent that included Charles Drouhet, his grandfather was a medical doctor in France. Victoria Drouhet was Edouard Drouhet's spouse. In 1944, he received his doctorate in medicine from the University of Bucharest. However, the diploma from Bucharest was not considered equivalent to the education in France and he was expected to pass baccalaureat to thesis diplomas in France. In 1947, Drouhet studied microbiology at the Institut Pasteur and in 1948 studied serology and dermatology at the Institut Fournier.

Throughout Drouhet's life, he held many positions in which he was able to build upon and connect the mycologist community. In 1948, Drouhet was appointed the position of a research associate at Centre National de la Recherche Scientifique. In 1953, he became Head of Laboratory at the Pasteur Institute under Professor Magrou. At the Pasteur Institute, he met Francois Mariat; the colleagues formed a team that promoted awareness and advanced the field of medical mycology in France and Europe. Together, they organized a post-graduate course in medical mycology which had trained hundreds of mycologists in France and other foreign entities. In addition, they founded the French Society of Medical Mycology. Gabriel Segretain and Edouard Drouhet co-founded ISHAM, a community for clinical scientists and researchers interested in fungal ailments and fungus-like diseases. In 1996, the trio received the E. Brumpt Prize of the Society of Exotic Pathology. In 1972, Drouhet was appointed as professor at Institut Pasteur.

In this position, he formed the National Reference Center for Antifungals. In 1981 he would take the place of Grabriel Segretain as Director of the Mycology Unit at Pasteur Institute until he retired in 1987. After retirement, Drouhet continued in his involvement in the scientific community by serving as the Chief Editor for the Journal of Medical Mycology until he fell ill in 1999. Towards the end of his career, he was able to publish and share his identification of a new thermally dimorphic fungal species, Emmonsia pasteuriana, first cultured on a woman with HIV from Italy. Prior to Drouhet's influence, Institut Pasteur studied fungal pathogens on botany. Since Drouhet had opened up the field to include human and animal fungal pathogens as well. Drouhet's work looked into diseases of opportunistic fungi pathogens in humans and animals and he was the first in France to test the antifungal agents, he extensively studied the serum of fungal antigens such as fluconazole, amphotericin-B, itraconazole which helped standardize the medical dosage and treatments for patients.

In 1978, Drouhet published a textbook called "Fungal Antigens – Isolation and Detection", conceived after a symposium on fungal antigens. The book goes in depth of chemical techniques, methods of diagnosing infections, includes studies on Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Coccidiodes immitis, many more contributed by a collection of other authors. In Drouhet and Dupont's publication of “Laboratory and Clinical Assessment of Ketoconazole in Deep-Seated Mycoses”, they studied how patients with deep mycoses reacted with treatments of ketoconazole and amphotericin B. Both of which, were ineffective to treating mycoses as separate medications; the cases included a wide range of mycoses such as candidiasis, African blastomycosis, fungal arthritis, newly discovered cases of cutaneous and osteoarticular manifestations of candidiasis in young heroin addicts. Another noteworthy publication of Drouhet's is, “Early experience with itraconazole in vitro and in patients: pharmacokinetic studies and clinical results” when itraconazole was considered a new antifungal agent.

He studied mycoses with AIDS patients and other immunocompromised patients

John Muckle

John Muckle is a British writer who has published fiction and literary criticism. Born in Kingston-upon-Thames, he grew up in the village of Surrey. After qualifying as a teacher and working in London FE colleges, he moved into book publishing, first for literary publisher Marion Boyars, moving on to Grafton Books as a paperback copywriter. In the mid-1980s he initiated the Paladin Poetry Series. Muckle was general editor of its flagship anthology The New British Poetry, commissioning a number of other titles before he left; the poetry imprint was edited subsequently by writer Iain Sinclair. Muckle worked as a freelance copywriter for Penguin before returning to teaching, for five years at Essex University in various other jobs; the Cresta Run, Muckle's first book, was reviewed enthusiastically by Norman Shrapnel in The Guardian: "An identifiable vernacular for this still measurable sector of the populace - working-class if not always working - is amply available and John Muckle's excellent stories prove it.

The territory of The Cresta Run is short on introverts. In 1989 he received a Hawthornden Writers' Fellowship. Writing of Cyclomotors, John Berger said: "It's a wonderful book - marvellously constructed and of a fidelity to experience such as you only come across with a true storyteller - as distinct from word-spinner." This hard-to-classify fiction was praised by a number of prominent writers. Will Self wrote: "I don't think I've read anything for quite a while - not since Norman Lewis's memoir Jackdaw Cake - which conjures up quite so this peculiar inter-zone between the behemoth of the city and the hinterland of the country, and on top of all this there is the wrenching portrayal of a family at odds with itself in the most violent fashion, rendered without cant or sentimentality." Muckle has published further novels, poetry collections, a critical work on British fiction in the 1950s and 1960s, as well as essays and reviews on poetry and poets, including Allen Ginsberg, Ed Dorn, Bill Griffiths, Tom Raworth, Denise Riley, Lee Harwood and many others.

It Is Now As It Was Then The Cresta Run Bikers Cyclomotors Firewriting and Other Poems London Brakes My Pale Tulip Little White Bull: British Fiction in the Fifties and Sixties Falling Through Mirrorball As editor The New British Poetry 1968-88 Active in Airtime - a journal of poetry and fiction Ian Brinton, review of London Brakes at Eyewear http://toddswift.blogspot.co.uk/2011/02/guest-review-brinton-on-muckle.html Andrew Duncan, The Failure of Conservatism in Contemporary Poetry Robert Hampson,'Memory, False Memory' in New Formations, Issue 50: Autumn 2004 Sandra Newman, Changeling: A Memoir Of Parents Lost And Found Robert Sheppard, The Poetry of Saying: British Poetry and Its Discontents 1950-2000 John Muckle,'The Names: Allen Ginsberg's Writings' in A. Robert Lee The Beat Generation Writers Shearsman author page http://www.shearsman.com/browse-poetry-books-by-author-John-Muckle PN Review online http://www.pnreview.co.uk/cgi-bin/scribe?showauthor=943'Firewriting' on Shearsman website http://www.shearsman.com/ws-public/uploads/223_firewriting.pdf'Hazlitt's Paroxysms' at Jacket Magazine http://jacketmagazine.com/36/muckle-hazlitt.shtml D.

J. Taylor, review of Little White Bull: British fiction in the Fifties and Sixties in TLS http://www.the-tls.co.uk/tls/multimedia/archive/01119/contents_1119460a.pdf Steve Spence, review of Little White Bull at Stride Magazine http://www.stridemagazine.co.uk/Stride%20mag%202015/Jan2015/LittleWhiteBull. Spence.htm

Henry Street, Fremantle

Henry Street is a 400-metre-long street in Fremantle, Western Australia. It was named after second lieutenant of HMS Challenger, it was developed early in the history of the Swan River Colony with licensed premises being located as early as 1833. Henry Street has seen significant funeral processions pass along it on their way to the Fremantle Cemetery, it has some significant historical buildings, including Falk & Company Warehouse, Fowler's Warehouse, Fremantle Customs House, the Marich Buildings, the Moore's Building, the Bateman Hardware building and the Orient Hotel. 33 Henry Street was a regular meeting place for a range of Fremantle associations