Geranylfarnesyl diphosphate synthase

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Geranylfarnesyl diphosphate synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Geranylfarnesyl diphosphate synthase (EC, FGPP synthase, (all-E) geranylfarnesyl diphosphate synthase, GFPS, Fgs) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 1 isopentenyl unit).[1][2][3][4] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + isopentenyl diphosphate (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate

The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine.


  1. ^ Ogawa, T.; Yoshimura, T.; Hemmi, H. (2010). "Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution". Biochem. Biophys. Res. Commun. 393: 16–20. doi:10.1016/j.bbrc.2010.01.063. PMID 20097171.
  2. ^ Tachibana, A.; Yano, Y.; Otani, S.; Nomura, N.; Sako, Y.; Taniguchi, M. (2000). "Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecular evolution with alteration in product specificity". Eur. J. Biochem. 267: 321–328. doi:10.1046/j.1432-1327.2000.00967.x. PMID 10632701.
  3. ^ Tachibana, A. (1994). "A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis". FEBS Lett. 341: 291–294. doi:10.1016/0014-5793(94)80475-3. PMID 8137956.
  4. ^ Lee, P.C.; Mijts, B.N.; Petri, R.; Watts, K.T.; Schmidt-Dannert, C. (2004). "Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution". Protein Eng. Des. Sel. 17: 771–777. doi:10.1093/protein/gzh089. PMID 15548566.

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