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A.D. 2044

A. D. 2044 is a Polish adventure game by LK Avalon, released September 1996 on Windows. The game is a remake of a 1991 game entitled A. D. 2044: Seksmisja developed by R. M. P. Software and published by LK Avalon, released to Atari 8-bit computers, it was a simple click adventure game created by Roland Pantoła. The new game is based with updated graphics; this version of the game became a huge hit. It was the first Polish computer game released on two CDs and to have rendered three-dimensional graphics; the game was accompanied by a promotion, unprecedented in scale for the country. While the game was released in Polish, English subtitles were added to the game in 2017. Based on the film Seksmisja by Juliusz Machulski, the game is set in a future post-apocalyptic world where women rule the planet; this is caused by a radical women's group who capture some nuclear weapons and demand equal power from men, who respond by sending missiles which causes a nuclear winter. A thousand woman survive from being in an underground bunker.

In 2044, they discover a single male, preserved in a hibernation capsule. The player is this male who begins to explore the environment; the game plays like a click adventure. Players manipulate items and click on hotspots. A male voice narrates the story and provides hints. Gra.pl felt the 1991 version should be treated as a mere "interesting curiosity" in comparison to the more "interesting and better developed" one from 1996. Metzomagic noted the game window was more generous that in other games, reaching around two-thirds of the screen. Imperium Gier felt that while the game was once considered good, by modern day standards it is average. Rock, Shotgun was turned off the game after reading the synopsis. Gry Online thought the game's visual design was its draw card

A Demon for Trouble

A Demon for Trouble is a 1934 American black-and-white action/adventure/romance short film directed by Robert F. Hill and produced by A. W. Hackel for Supreme Pictures, it stars Bob Steele, Don Alvarado, Gloria Shea, Nick Stuart and was released in the United States on August 10, 1934. Bob Steele had just left Monogram Pictures; the film was the first of an eight picture contract. Having been wrongly accused of the murder of Buck Morton, Bob Worth is now on the run from the sheriff. With the help of outlaw Gallinda, Bob must somehow prove that the real culprit is real estate mogul Dyer. Nick Stuart played a key support role. Bob Steele filmography A Demon for Trouble on IMDb Complete copy of film at YouTube

Carcinoid

A carcinoid is a slow-growing type of neuroendocrine tumor originating in the cells of the neuroendocrine system. In some cases, metastasis may occur. Carcinoid tumors of the midgut are associated with carcinoid syndrome. Carcinoid tumors are the most common malignant tumor of the appendix, but they are most associated with the small intestine, they can be found in the rectum and stomach, they are known to grow in the liver, but this finding is a manifestation of metastatic disease from a primary carcinoid occurring elsewhere in the body. They have a slow growth rate compared to most malignant tumors; the median age at diagnosis for all patients with neuroendocrine tumors is 63 years. While most carcinoids are asymptomatic through the natural lifetime and are discovered only upon surgery for unrelated reasons, all carcinoids are considered to have malignant potential. About 10% of carcinoids secrete excessive levels of a range of hormones, most notably serotonin, causing: Flushing. Potential causes of flushing in carcinoid syndrome include bradykinins, tachykinins, substance P, and/or histamine and heart problems.

Because of serotonin's growth-promoting effect on cardiac myocytes, a serotonin-secreting carcinoid tumour may cause a tricuspid valve disease syndrome, due to the proliferation of myocytes onto the valve. Diarrhea Wheezing Abdominal cramping Peripheral edemaThe outflow of serotonin can cause a depletion of tryptophan leading to niacin deficiency. Niacin deficiency known as pellagra, is associated with dermatitis and diarrhea; this constellation of symptoms is called carcinoid crisis. Haemorrhage or the effects of tumor bulk are the presenting symptoms; the most common originating sites of carcinoid is the small bowel the ileum. Carcinoid tumors may arise from the ovary or thymus, they are most found in the midgut at the level of the ileum or in the appendix. The next most common affected area is the respiratory tract, with 28% of all cases—per PAN-SEER data; the rectum is a common site. Carcinoid tumors are apudomas. Over two-thirds of carcinoid tumors are found in the gastrointestinal tract. Carcinoid tumors are found in the lungs.

Metastasis of carcinoid can lead to carcinoid syndrome. This is due to the over-production of many substances, including serotonin, which are released into the systemic circulation, which can lead to symptoms of cutaneous flushing, bronchoconstriction, right-sided cardiac valve disease, it is estimated that less than 6% of carcinoid patients will develop carcinoid syndrome, of these, 50% will have cardiac involvement. This is considered to be a hybrid between an exocrine and endocrine tumor derived from crypt cells of the appendix. Histologically, it forms clusters of goblet cells containing mucin with a minor admixture of Paneth cells and endocrine cells; the growth pattern is distinctive: producing a concentric band of tumor nests interspersed among the muscle and stroma of the appendiceal wall extending up the shaft of the appendix. This makes the lesion difficult to measure. Small tumor nests may be camouflaged in periappendiceal fat, they behave in a more aggressive manner. Spread is to regional lymph nodes and the ovary.

They do not produce sufficient hormonal substances to cause the carcinoid or other endocrine syndromes. In fact, they more resemble exocrine than endocrine tumors; the term'crypt cell carcinoma' has been used for them, though more accurate than considering them carcinoids, has not been a successful competitor. Carcinoid syndrome involves multiple tumors in 1/5 of cases; the incidence of gastric carcinoids is increased in achlorhydria, Hashimoto's thyroiditis, pernicious anemia. Surgery, if feasible, is the only curative therapy. If the tumor has metastasized and is considered incurable, there are some promising treatment modalities, such as radiolabeled octreotide or the radiopharmaceutical 131I-mIBG for arresting the growth of the tumors and prolonging survival in patients with liver metastases, though these are experimental. Chemotherapy is of little benefit and is not indicated. Octreotide or lanreotide may decrease the secretory activity of the carcinoid, may have an anti-proliferative effect.

Interferon treatment is effective, combined with somatostatin analogues. As the metastatic potential of a coincidental carcinoid is low, the current recommendation is for follow up in 3 months with CT or MRI, labs for tumor markers such as serotonin, a history and physical, with annual physicals thereafter, they were first characterized in 1907 by Siegfried Oberndorfer, a German pathologist at the University of Munich, who coined the term karzinoide, or "carcinoma-like", to describe the unique feature of behaving like a benign tumor despite having a malignant appearance microscopically. The recognition of their endocrine-related properties were described by Gosset and Masson in 1914, these tumors are now known to arise from the enterochromaffin and enterochromaffin-like cells of the gut; some sources cr

Tyler Lorenzen

Tyler John Lorenzen is a former American football tight end. He was signed by the Jacksonville Jaguars as an undrafted free agent in 2009, he played for the New Orleans Saints. He played college football for the University of Connecticut, he is the CEO of Puris Foods, a pea protein producer based in Minneapolis. Lorenzen attended Eddyville-Blakesburg High School, where he led the football team to two state playoff appearances. Previous to playing at the University of Connecticut, Lorenzen played a season at Palomar College in San Marcos, California. Following his season at Palomar, he was rated the No. 2 junior college quarterback prospect in the nation for the class of 2007 by JCGridiron.com. Lorenzen played college football at Connecticut, where he was a quarterback and started 21 games in two seasons for the Huskies. Although he played quarterback in college, Lorenzen converted to tight end as a pro. After first signing with Jacksonville in April 2009, he moved to the Saints practice squad in September and was with the team for its Super Bowl winning 2009 season.

Cut by the Saints in September 2010, he spent several months working in his family's soybean genetics business before the Saints re-signed him in December. New Orleans Saints bio Jacksonville Jaguars bio UConn Huskies bio

Dennis Kipruto Kimetto

Dennis Kipruto Kimetto is a Kenyan long distance runner who competes in road running events. He was the world record holder in the men's marathon with a time of 2 hours 2 minutes 57 seconds, a record which he held until Eliud Kipchoge broke it in 2018 with a time of 2:01:39. Hailing from Eldoret and part of a training group including Geoffrey Mutai, Kimetto's first major win came in the half marathon section of the Nairobi Marathon in 2011. Running as Dennis Koech, he topped the podium in a time of 1:01:30, he rose into the global running elite in his first outings outside of Kenya. At the RAK Half Marathon he defeated a field including Wilson Kipsang Kiprotich to win the race in 60:40 minutes, his age was misreported as ten years younger, his following run of 59:14 minutes to win the Berlin Half Marathon in April was considered a world junior best. An erroneous passport was the cause of both the age difference and the Koech misnomer, his surname being Kimetto; this was rectified in competitions.

With Kimetto's personal data corrected, he went on to break his first major record at the BIG 25 Berlin. His time of 71:18 for 25 kilometres knocked a sizeable margin off Sammy Kosgei's world record of 71:50. After this he made the fastest marathon debut in history that September. Again in Berlin, he ran alongside Geoffrey Mutai for much of the race as he recorded a time of 2:04:16, one second behind Mutai, to set the fifth fastest time run at that point; some reporters observed that Kimetto stayed solidly behind the more prominent Mutai in the final section of the race and concluded that he allowed his partner to take the victory which clinched a World Marathon Majors series title for Mutai. In 2013 Kimetto set two World Marathon Majors course records, at Tokyo in 2:06:50 and at Chicago in 2:03:45, the fastest time on American soil for a record quality course. On 28 September 2014, Kimetto broke the world record at the Berlin Marathon with 2:02:57 and became the first man to run under 2:03.

His 5-kilometre splits were recorded as 14:42, 14:42, 14:46, 14:26, 14:32, 14:30, 14:09, 14:42. His second half of 1:01:12 was the fastest in history excluding those from the downhill and wind-aided 2011 Boston Marathon, his 2015 season wasn't as impressive as he only completed the London Marathon, finishing third, failing to complete the IAAF World Championships marathon in Beijing in August as well as the Fukuoka Marathon in December where he stopped at the 5-kilometre mark after dropping off the pace at 2 kilometres due to an injury. After finishing ninth at the 2016 London Marathon, Kimetto removed himself from consideration for the Rio Olympics, intending instead to run in the Chicago Marathon. However, he pulled out ahead of the race. Kimetto's injury problems continued in 2017, with a knee injury forcing him to withdraw from the field for the Boston Marathon, he failed to finish both the Honolulu Marathon in December. At the Vienna City Marathon in April 2018 Kimetto dropped out before the 25-kilometre point.

Kimetto grew up in a rural farming community. "I think what motivates me to be a fighter is the fact that I come from a humble background," Kimetto says. "I try to make sure that I achieve my best so that I can assist my family." All results regarding marathon and half marathon Dennis Kipruto Kimetto at World Athletics