Glenn Hughes is an English rock bassist and vocalist, best known for playing bass and performing vocals for funk rock pioneers Trapeze, the Mk. III and IV line-ups of Deep Purple, as well as fronting Black Sabbath in the mid-1980s. Hughes is known by fans as "The Voice of Rock" due to his soulful and wide-ranging singing voice. In addition to being an active session musician, Hughes maintains a notable solo career, he fronts the supergroups Black Country Communion and The Dead Daisies and fronted California Breed from 2013 to 2015. On 8 April 2016, Hughes was inducted into the Roll Hall of Fame as a member of Deep Purple. Hughes was born in Cannock, England on 21 August 1951, he fronted Finders Keepers in the 1960s as bassist/vocalist, as well as the British funk rock band Trapeze. Hughes was recruited to replace Roger Glover as bassist in Deep Purple in 1973, though he considered himself more a vocalist than a bassist, he was uninterested in the Deep Purple job until some of the other members proposed that Paul Rodgers of Free be brought in as co-lead vocalist.
Although the recruitment of Rodgers fell through, Hughes had now become interested in the "two-lead-singer thing", David Coverdale was hired as Deep Purple's lead vocalist. The two would share lead vocal duties in the band for the next three albums, until the break-up of Deep Purple in 1976. Battling a severe cocaine addiction, Hughes embarked on a solo career following his departure from the group, releasing his first solo album in 1977 called Play Me Out. In 1982, he joined with ex-Pat Travers guitarist Pat Thrall to form Hughes/Thrall, they released one self-titled album which went unnoticed at the time. Part of the reason for the album's obscurity was the inability to support it with a proper tour due to both parties suffering from drug addiction; as Hughes stated in a 2007 interview, "The Hughes-Thrall album was a brilliant, brilliant album, but we only did 17 shows because we were too loaded." In the mid-1980s, Hughes recorded several different albums with bands and artists including Phenomena, Gary Moore, Black Sabbath.
Hughes' health problems due to overeating and alcohol began to affect his musical projects, this contributed to short stints with Gary Moore and Tony Iommi, as Hughes was unable to tour with them properly due to his bad health. In 1985 Black Sabbath re-united with original vocalist Ozzy Osbourne for the one-off Live Aid performance. While waiting for a break in Osbournes' career, Iommi decided to record a solo album and Hughes was brought in to provide the vocals. Due to the aforementioned contractual obligations with the record company the album was released as Black Sabbath featuring Tony Iommi in 1986, to positive critical reviews, with Hughes in particular putting in a fine performance. While touring to promote the new album Glenn was replaced by vocalist Ray Gillen after six shows due to a fight with Black Sabbath's production manager, as the injuries contributed to a degradation in his voice and he was in no physical shape to complete the tour. By the end of the decade, Hughes' realised his ongoing drug problem was derailing him, by 1991 a clean and rejuvenated Hughes returned with the vocal for the hit "America: What Time Is Love?" with KLF.
He recorded all the vocals for former Europe guitarist John Norum's solo album Face the Truth. He re-embarked on a solo career, his primary focus to date. In 1999, Hughes did a short tribute tour to Tommy Bolin in Texas, with Tommy's brother Johnnie on drums. In 2005 Hughes released Soul Mover supporting it with a European tour, he collaborated with Black Sabbath guitarist Tony Iommi on the 2005 album Fused. Hughes released Music for the Divine in 2006, which featured Red Hot Chili Peppers members Chad Smith and John Frusciante. Hughes toured in support of the album throughout Europe in autumn 2006. Released on Edel Records on 17 November 2007 is Live in Australia, an acoustic CD and companion DVD of a performance at Sydney's famous "Basement" club; the album First Underground Nuclear Kitchen was released on 9 May 2008 in Europe and on 12 May in the rest of the world. In 2009, Hughes formed Black Country Communion with Joe Bonamassa and Derek Sherinian; the band released three albums through 2012 and disbanded in March 2013 following the departure of guitarist Bonamassa.
Black Country Communion reunited in 2016 and released a fourth album in 2017. In July 2010 Hughes appeared as a guest vocalist fronting Heaven & Hell at the High Voltage Rock Festival in London as a tribute to the late Ronnie James Dio. Hughes' autobiography was published in May 2011 by British specialist limited edition publishers Foruli; the book, titled'Deep Purple And Beyond: Scenes From The Life Of A Rock Star', was co-written with author Joel McIver and featured contributions by Tony Iommi, David Coverdale, Ozzy Osbourne and Tom Morello, as well as a foreword by Lars Ulrich of Metallica. An extended paperback edition, retitled'Glenn Hughes: The Autobiography', was published in late 2011 by Jawbone Press. In 2003 Hughes make a guest appearance in "AINA", a metal opera project, in the debut album "Days of Rising Doom", alongside with other guest vocalists like Michael Kiske, Tobias Sammet, Andre Matos, Simone Simons and others. On 13 September 2012 Glenn Hughes and Derek Sherinian met Bako Sahakyan, the president of the breakaway Nagorno-Karabakh Republic and organised a concert in Stepanakert.
In 2013, Hughes m
Isoantibodies are antibodies produced by an individual against isoantigens produced by members of the same species. In the case of the species Homo sapiens, for example, there are a significant number of antigens which are different in every individual; when antigens from another individual are introduced into another's body, these isoantibodies bind to and destroy them. One common example is the isohaemagglutinins; this may subjectively differ from the term'natural' antibodies or simply'antibodies' as the former seem to arise from genetic control without apparent antigenic stimulation whereas the latter arise due to antigenic stimulation. A protein or other substance, such as histocompatibility or red blood cell antigens, present in only some members of a species and therefore able to stimulate isoantibody production in other members of the same species who lack it; when injected into another animal, they trigger an immune response aimed at eliminating them. Therefore, it can be thought of as an antigen, present in some members of the same species, but is not common to all members of that species.
If an alloantigen is presented to a member of the same species that does not have the alloantigen, it will be recognized as foreign. They are the products of polymorphic genes. Isoantibodies are seen in people with different blood groups; the anti-A or anti-B isoantibodies or both are produced by an individual against the antigens on the RBCs of other blood groups. In a person with A blood group, the plasma will contain isoantibodies against B antigens, so after transfusion of blood from B group the anti-B isohemagglutinins agglutinate the foreign red blood cells. Anti-A and anti-B antibodies, which are not present in the newborn, appear in the first years of life, it is possible that food and environmental antigens have epitopes similar enough to A and B glycoprotein antigens. The antibodies created against these environmental antigens in the first years of life can cross react with ABO-incompatible red blood cells when it comes in contact with during blood transfusion in life. Anti-A and anti-B antibodies are IgM type.
Glycidamide is part of the chemical group of amides and oxiranes, it is classified as a carcinogenic substance. It is associated with tobacco either as natural component, pyrolysis product in tobacco smoke or additive for one or more types of tobacco products. Glycidamide is formed from acrylamide. Acrylamide is an industrial chemical, used in several ways, such as production of polyacrylamides for water treatment, paper processing and cosmetics, it is a product formed in certain foods prepared at high temperature frying, baking or roasting, such as fried potatoes, bakery products and coffee. Glycidamide is formed through the reaction of unsaturated fatty acids with oxygen, it is a dangerous substance, since it causes small mutations in cells which can result in several forms of cancer. Two of the first researchers who acknowledged the existence of glycidamide were Murray and Cloke in 1934, they performed experiments on glycidamide formation. Since glycidamide is a metabolite of acrylamide, not much studies has been done on glycidamide on its own.
Most of the studies focus on the effects of acrylamide, whereas less studies focus on the effects of glycidamide. There are many studies that combine acrylamide and glycidamide, but the focus is still on acrylamide. Glycidamide is a reactive epoxide metabolite from acrylamide. Glycidamides are fine crystals with lumps with a light orange color, it can react with nucleophiles. This results in covalent binding of the electrophile. There is no data on the odor of glycidamide. Glycidamide gives a positive response in the Ames/Salmonella mutagenicity assay, which indicates that it can cause mutations in the DNA. Glycidamide is formed by oxidation of acrylamide by cytochrome P450 2E1; this reaction follows Michaelis-Menten kinetics. Due to this reaction, glycidamide becomes critical to the genotoxicity of acrylamide. Saturated fatty acids protect the acrylamide from forming glycidamide; when during food processing, oil is used that contains unsaturated fatty acids, the amount of glycidamide formed is much higher.
The first experiments on glycidamide formation were done by Cloke. They tried to form glycidamides from α,β-ethylenic nitriles. In order to do so, they used the modified Radziszewski reaction; the Radziszewski reaction refers to a method for the preparation of amides, described by Radziszewski in 1885. The amides are prepared “by the action of 3% hydrogen peroxide on nitriles in the presence of alkali and at a temperature of 40 degrees Celsius”; the reaction was modified by adding methanol and acetone. Some nitriles did indeed give glycidamides. Glycidamide is more reactive to DNA than acrylamide. Several glycidamide-DNA adducts have been characterized; the main DNA adducts are N7 -- N3-adenine. Glycidamide reacts with haemoglobine to form a cysteine adduct, S-cysteine. With this reaction, N-terminal valine adducts are formed. There are two isomers of this connection: the mirror image - Glycidamide; the racemate -Glycidamide is a 1:1 mixture of both isomers. The epoxide is a strong alkylating agent.
This reactive ion can alkylate it. Alkylation of DNA can cause mutagenicity. There are tumors observed at the site of exposure. Inhibition of the sodium/potassium ATPase protein present in the plasma membrane of the nerve cell is caused by glycidamide. Intracellular sodium increases and intracellular potassium decreases due to this inhibition; this causes depolarization of the nerve membrane. The depolarization triggers a reverse sodium/calcium exchange, which will cause calcium-mediated axon degeneration; the liver is a active organ in the metabolism of xenobiotics. Substances in the liver modify the compounds to make them more soluble in water, in order to excrete them through bile and urine; this modification, can result in a greater toxicity of the compound. Whether this is the case for glycidamide remains unclear. Glycidamide can be detoxified through different pathways to glycidamide-glutathione conjugates. There is an enzymatic pathway via a non-enzymatic pathway; these glycidamide-glutathione conjugates are further metabolized to mercapturic acids by different peptidases and transferases, such as gamma-glutamyl-transpeptidase, dipeptidase and N-acetyltransferase.
The mercapturic acids that can be formed are N-acetyl-S--cysteine, N-acetyl-S--cysteine, N-acetyl-S--cysteine. These mercapturic acids are excreted through urine. Glycidamide can be hydrolyzed to glyceramide both spontaneously or enzymatically by microsomal epoxide hydrolase; this too can be excreted through urine. The DEREK NEXUS assessment shows that it is plausible that glycidamide is carcinogenic, neurotoxic, developmental toxic and oestrogenic, it shows that it is plausible that glycidamide causes chromosome damage and irritation of the eye and skin. The results of this assessments are confirmed by the Hazard Identification of lookchem, it states that glycidamide may heritable genetic damage. It causes skin and eye irritation. Mice and rats are used for most of the studies of glycidamide; these are used, because the formation of glycidamide adducts is directly proportional in man and rat. Studies with Big Blue m
The Republikanischer Schutzbund was an Austrian paramilitary organization established in 1923 by the Social Democratic Party to secure power in the face of rising political radicalization after World War I. It had a Czech section associated with the Czechoslovak Social Democratic Workers Party in the Republic of Austria; the Republikanischer Schutzbund was one of many paramilitary forces to organize after the fall of the Austria-Hungary Empire. This one in particular was a branch of the Social Democratic Workers' Party, its purpose was to defend the party and to maintain the balance of power amidst increasing radicalization of politics in Austria. This includes a good amount of saber rattling between the Schutzbund and the conservative Heimwehr, as encouraged by the SDAPÖ newspaper, the Arbeiter Zeitung. On 30 January 1927 a veterans' group clashed with the Schutzbund, leaving one veteran and one child killed by the right-wing Heimwehr; the results of the trial led to the July Revolt of 1927.
By June 1933, Federal Chancellor Engelbert Dollfuß banned the Schutzbund. On 11 February 1934 the Heimwehr commander in Vienna Emil Fey called for the disarmament of the Schutzbund. Upon raiding Hotel Schiff in Linz, the Linz Schutzbund commander Richard Bernaschek resisted, resulting in armed conflict known as the Austrian Civil War. List of defunct paramilitary organizations List of paramilitary organizations Paramilitary Reichsbanner Schwarz-Rot-Gold, paramilitary organization of the German SPD
The Arrow Coax Livella Uno is a German helicopter under development by Arrow Coax Ultra Light Helicopter of Hornhausen and introduced at the AERO Friedrichshafen airshow in 2015. The aircraft is intended to be supplied as a kit for amateur construction; the Livella Uno was designed to comply with the US FAR 103 Ultralight Vehicles and the European 120 kg class ultralight aircraft rules. It features a dual coaxial main rotors, with an inverted V-tail, a single open-air pilot's seat without a windshield, tricycle landing gear and a 40 hp Wankel Aixro XH40 engine; the aircraft fuselage is made from tubing. Its two-bladed rotors have a diameter of 3.8 m. The aircraft has a typical empty weight of 85 kg and a gross weight of 195 kg, giving a useful load of 110 kg; the aircraft mounts a Galaxy Rescue System ballistic parachute in the rotor mast. It has a small electric motor to power the rotor system from a battery in the event of an engine failure, allowing five minutes of power to land, since the low inertia rotor blades may not support autorotation.
Data from TackeGeneral characteristics Crew: one Empty weight: 85 kg Gross weight: 195 kg Powerplant: 1 × Aixro XH40 liquid-cooled, Wankel aircraft engine, 30 kW Main rotor diameter: 2× 3.8 m Main rotor area: 23 m2 Performance Maximum speed: 110 km/h Cruise speed: 90 km/h Disk loading: 8.5 kg/m2 List of rotorcraft Photo of the Livella Uno prototype
Carl Gotthard Langhans was a Prussian master builder and royal architect. His churches, grand houses, city gates and theatres in Silesia, Berlin and elsewhere belong to the earliest examples of Neoclassical architecture in Germany, his best-known work is the Brandenburg Gate in Berlin, national symbol of today’s Germany and German reunification in 1989/90. Langhans was born in Silesia, he was not educated as an architect. He studied law from 1753 to 1757 in Halle, mathematics and languages, engaged himself autodidactically with architecture, at which he concentrated on the antique texts of the Roman architecture theorist Vitruvius, his draft for "Zum Schifflein Christi", the Protestant Church in Groß-Glogau, earned him his first recognition as an architect. In the same year, he received an appointment as building inspector for the Count of Hatzfeld, whose war-ravaged palace Langhans rebuilt to his own design between 1766 and 1774. Through the intervention of the Count of Hatzfeld, he became known in the royal court in Berlin.
As his first work in the service of the royal family, he built in 1766 the stairwell and the Muschelsaal in Rheinsberg Palace. From 1775 until 1788, Langhans headed the building authority for the Prussian province of Silesia. In 1788, the Prussian King Frederick William II appointed him as first director of the royal building commission in Berlin, he died on his estate at Grüneiche near Breslau. In 1771, Langhans married the daughter of a jurist in Breslau, they had five children: daughters Louise Amalie and Juliane Wilhelmine, a son, theater architect Carl Ferdinand, as well as two other children, who died soon after birth. From 1782 he lived with his family in his in-laws' house at Albrechtstraße 18 in Breslau. In 1788, they moved to Berlin, where he built his own house and lived at Charlottenstraße 31, at the corner of Behrenstraße. Toward the end of the 18th century and the beginning of the 19th century, it was a great dream for every artist to undertake a trip to Italy in order to be able to study the antique buildings with one's own eyes.
The fulfillment of this dream was not granted only to Goethe and Schinkel, but Langhans, was able to afford a trip in 1768 and 1769 thanks to the support of the Count of Hatzfeld. When he was assigned to be the head of the Breslau war and dominion chamber, he visited England, Holland and France on behalf of and at the expense of the king