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Glucosidases are glycoside hydrolase enzymes categorized under the EC number 3.2.1.


α-glucosidases are enzymes involved in breaking down complex carbohydrates such as starch and glycogen into their monomers

They catalyze the cleavage of individual glucosyl residues from various glycoconjugates including alpha- or beta-linked polymers of glucose.This enzyme convert complex sugars into the simpler one.


Different sources include different members in this class. Members marked with a "#" are considered by MeSH to be glucosidases.

Name EC Description
α-Amylase EC is a digestive enzyme in mammals
β-Amylase EC is a plant enzyme to break down starch
γ-Amylase EC is a digestive enzyme
Cellulase # EC breaks down cellulose from plant material
Sucrase-isomaltase EC -
Mannosyl-oligosaccharide glucosidase # EC catalyzes the first trimming step of the N-glycosylation pathway; is associated with Congenital Disorder of Glycosylation type IIb
Acid α-glucosidase # EC is associated with Glycogen storage disease type II
Beta-glucosidase # EC - is associated with gaucher's disease
Lactase EC one member of the β-galactosidase family, breaks down milk sugars, and its absence in adulthood causes lactose intolerance
Debranching enzyme # EC In mammals, yeast and some bacteria, combines transferase and glucosidase activity in glycogen breakdown
Pullulanase EC has been used as a detergent

Clinical significance[edit]

They are targeted by alpha-glucosidase inhibitors such as acarbose and miglitol to control diabetes mellitus type 2.

See also[edit]

External links[edit]