Gonadorelin is a gonadotropin-releasing hormone agonist, used in fertility medicine and to treat amenorrhea and hypogonadism. It is used in veterinary medicine; the medication is identical to it in chemical structure. It is given by injection as a nasal spray. Gonadorelin is used as a diagnostic agent to assess pituitary gland function, it is used in the treatment of primary hypothalamic amenorrhea, hypogonadotropic hypogonadism, delayed puberty and infertility. Unlike other GnRH analogues, it is not used to suppress sex hormone production. Gonadorelin is available in a portable infusion pump that provides pulsatile subcutaneous administration of the drug; the usual dosage delivered is 5 to 20 μg of gonadorelin per pulse every 90 to 120 minutes. It is available in solution form for intravenous or subcutaneous injection and as a nasal spray. Gonadorelin is an agonist of the GnRH receptor and is used to induce the secretion of the gonadotropins follicle-stimulating hormone and luteinizing hormone from the pituitary gland and to increase sex hormone production by the gonads.
Gonadorelin has a distribution half-life of 2 to 10 minutes and a short terminal half-life of 10 to 40 minutes. It is metabolized by hydrolysis into smaller peptide components. Gonadorelin was available for medical use, under the brand name Factrel, as early as 1978. Gonadorelin is the generic name of the drug and its INN, BAN, JAN, while gonadorelina is its DCIT and gonadoréline is its DCF; the diacetate salt is known as gonadorelin acetate and this is its USAN, BANM, JAN, while the hydrochloride salt is known as gonadorelin hydrochloride and this is its USAN and BANM. Free alcohol gonadorelin has been marketed under the brand names Cryptocur, Cystoréline, Fertagyl, GnRH Serono, Gonadorelin, HRF, Kryptocur, LH-RH, Pulstim, Relisorm L, Stimu-LH, Wyeth-Ayest HRF. Gonadorelin diacetate has been marketed under the brand names Kryptocur, LHRH Ferring, Lutrelef, Relisorm L, Relisorm. GnRH hydrochloride has been marketed under the brand names Factrel, HRF, Luforan. Additional brand names of gonadorelin and its salts include Acegon, Cystorelin, Equity Oestrus Control, Fertagyl Cattle, Gonabreed, Gonadorelin Interpharm, Gonavet Veyx, Improvest, LH RH Tanabe, LHRH Ferring, LH-RH Ferring, LH-RH Tanabe, OvaCyst, Ovsynch, OVsynch, Ovurelin and Relefact LH-RH.
The majority of these brand names are for veterinary use. Gonadorelin is available throughout the world for clinical and/or veterinary use, including in the United States, the United Kingdom, elsewhere throughout Europe, South Africa, New Zealand, Taiwan, in many other countries. Gonadotropin-releasing hormone receptor § Agonists
Rashepses was a vizier from the Fifth dynasty of Egypt. Rashepses was vizier under Djedkare Isesi. A letter directed to Rashepses has been preserved; this decree is inscribed in his tomb in Saqqara. As vizier he was one of the most important Ancient Egyptian officials. In his tomb are many titles recorded, it seems that he was first overseer of the scribes of the royal documents, overseer of the two granaries and overseer of all royal works. These are all important titles, making him an influential official at the royal court. At the final stage of his career he became vizier; the vizier title is only preserved in two letters. It seems that after all that, he was promoted. Rashepses was buried in Saqqara, it received the number LG16 from the expedition under Karl Richard Lepsius, that recorded the tomb in the middle of the 19th century. His mastaba is located north of funerary complex of Djoser among a group of tombs of the Fifth Dynasty, along with his contemporaries Perneb and Raemka; the tomb is decorated with classic images of the presentation of offerings and a set of scenes related to the funerary cult of the vizier.
The underground burial chamber is decorated with paintings. Decorated burial chambers are common in the Sixth Dynasty; the burial chamber of Rashepses might be the earliest decorated one. In the serdab, a head of a wooden statue was discovered with the type of headdress which became popular in the Sixth dynasty; this head is now in the Imhotep Museum. Strudwick, Nigel; the administration of Egypt in the Old Kingdom: the highest titles and their holders. Studies in Egyptology. London, Boston: KPI. ISBN 978-0-71-030107-9. Hany Abdallah El-Tayeb: The burial chamber of Rashepses at Saqqara, in: Egyptian Archaeology 44, 8-9
The Pusher is a 1960 American crime film directed and co-produced by Gene Milford and written by Harold Robbins. The film stars Robert Lansing, Felice Orlandi, Douglas Rodgers and Sloan Simpson; the film was released by United Artists. Kathy Carlyle as Laura Robert Lansing as Steve Carella Felice Orlandi as The Pusher Douglas Rodgers as Lt. Peter Byrne Sloan Simpson as Harriet Byrne Sara Amman as María Hernández Jim Boles as Newspaper vendor John Astin as Detective Beatrice Pons as Mrs. Hernandez Ernesto Gonzales as Ernesto John Fostini as Harry David Ford as Detective Kling William Doerner as Patrolman Genero Antonio Obregon as Shoeshine boy Jeno Mate as Bartender Lee Jones as Young man Donna Maran as Gert Joanna Merlin as Shoeshine boy's mother The Pusher on IMDb
The Los Blanquitos Formation is a geological formation in Salta Province, Argentina whose strata date back to the Campanian. Dinosaur remains are among the fossils; the formation comprises friable, grayish-red sandstones with quartz pebbles furrowed with small carbonate veins. In the base of this layer the remains of a titanosaurid dinosaur were discovered. Above the layer with bones appears a lens of thick, greenish-gray, calcareous hard sandstone with pebbles and gravel; the bones were covered by a "halo" of the same rock but of greenish or grayish color visible because the normal sediment is red. The bed thickness is 1.5 metres. Unquillosaurus ceiballi - "Pubis"? Titanosaurus sp. List of dinosaur-bearing rock formations J. F. Bonaparte and G. Bossi. 1967. Sobre la presencia de dinosaurios en la Formación Pirgua del Grupo Salta y su significado cronologico. Acta Geologica Lilloana 9:25-44 Powell, J. E. 2003. Revision of South American titanosaurid dinosaurs: palaeobiological, palaeobiogeographical and phylogenetic aspects.
Records of the Queen Victoria Museum Launceston 111:1-173 Powell, J. E. 1979. Sobre una asociacion de dinosaurios y otras evidencias de vertebrados del Cretacico superior de la region de La Candelaria, Prov. de Salta, Argentina. Ameghiniana 16: pp. 191–204
Nathan H. Glick was an American artist and illustrator best known for his work as a combat artist depicting aerial battles in World War II, he worked as art director for Progressive Farmer magazine, as the illustrator of several books on early Alabama history. Glick finished high school in Montgomery, he continued his art studies under Eric Pape and George Ennis in New York City and studied animal anatomy under James L. Clarke at the American Museum of Natural History. During the 1930s, Glick was art director for Paragon Press, a small publisher which issued history works by Alabama state archivist Marie Bankhead Owen, she commissioned him to design the scenes cast in bronze for the doors of Alabama's 1940 Alabama Department of Archives and History building. During World War II, Glick was assigned as combat artist for the Ninth Air Force, he created dramatic scenes of combat in the skies of North Africa, France and the South Pacific. The Air Force's public relations department distributed his drawings for publication in Yank and Stripes, The Illustrated London News and Parade.
After the end of the war, Glick returned to Birmingham and took a job as art director and illustrator for Progressive Farmer, retiring in 1977. He continued to contribute illustrations of Alabama history to books and helped create a series of fourteen murals for the United States Forest Service's Forest Heritage Center in Broken Bow, Oklahoma, his drawings and paintings are sold through private galleries. The "Nathan Glick Lifetime Achievement Award for Aviation Art" created by Birmingham's Southern Museum of Flight is named in his honor. Few, John "Noted WWII artist Nathan Glick visits Demopolis." Demopolis Times Strickland, Susan "Southeastern Aviation Art Expo gala set." Birmingham News Scenes from Alabama's History, information on the Alabama Archives Building's bronze doors
Jeremy C. Sivits is a former U. S. Army reservist, one of several soldiers charged and convicted by the U. S. Army in connection with the 2003–2004 Abu Ghraib prisoner abuse scandal in Baghdad, Iraq during and after the 2003 invasion of Iraq, he was a member of the 372nd Military Police Company during this time. Sivits took photographs at the Abu Ghraib prison which became notorious after being aired on 60 Minutes II, his father, David Sivits, a former serviceman, said that he was trained as a mechanic, not a prison guard, that he "was just doing what he was told to do." Sivits was the first soldier convicted in connection with the Abu Ghraib incidents. On May 5, 2004, Sivits was charged under Uniform Code of Military Justice with conspiracy to maltreat detainees, maltreatment of detainees, dereliction of duty for negligently failing to protect detainees from abuse and maltreatment, his special court-martial was held on May 2004 in Baghdad. Sivits testified against some of his fellow soldiers. Sivits's testimony included reporting seeing Charles Graner punching a naked detainee "with a closed fist so hard in the temple that it knocked the detainee unconscious."
Sivits testified seeing Lynndie England stomping on the feet and hands of detainees with her boots. Human Rights Watch and other human rights groups were not permitted to attend the trial; the court martial sentenced Sivits to the maximum sentence, one year of confinement, in addition to being discharged for bad conduct and demoted from specialist to private.in a recent interview he has shown remorse for his actions, claiming "to hate himself" Megan Ambuhl Lynndie England Ivan Frederick Charles Graner Sabrina Harman 372nd Military Police Company, the MP unit assigned to Abu Ghraib Standard Operating Procedure