Grenada County is a county located in the U.S. state of Mississippi. As of the 2020 Census, the population was 21,629. Its county seat is Grenada. The county was named for the province of Granada in southern Spain but spelled inaccurately. Its western half is part of the Mississippi Delta. Cotton cultivation was important to its economy well into the 20th century.

Grenada is a city in Grenada County, Mississippi, United States. The population was 13,092 at the 2010 census. It is the county seat of Grenada County.