HMCS Iroquois was the lead ship of the Iroquois-class destroyers of the Royal Canadian Navy, also known as the Tribal class or the 280 class. The second vessel to carry the name, she carried the hull number DDG 280. Entering service in 1972 she was assigned to Maritime Forces Atlantic (MARLANT) and was homeported at CFB Halifax. Iroquois was deployed overseas for blockade and anti-terrorism duties, including participating in Operation Apollo in 2002–03. Taken out of service in 2014 and paid off in 2015.

Iroquois-class destroyers, also known as Tribal class or DDG 280 class, were a class of four helicopter-carrying, guided missile destroyers of the Royal Canadian Navy. The ships were named to honour the First Nations of Canada.