Helena is the eastern portion of Helena–West Helena, Arkansas, a city in Phillips County, Arkansas, located on the west bank of the Mississippi River. It was founded in 1833 by Nicholas Rightor and is named after the daughter of Sylvanus Phillips, an early settler of Phillips County and the namesake of Phillips County. As of the 2000 census, this portion of the city population was 6,323. Helena was the county seat of Phillips County until January 1, 2006, when it merged its government and city limits with neighboring West Helena.

The Battle of Helena was fought on July 4, 1863, near Helena, Arkansas, during the American Civil War. Union troops captured the city in July 1862, and had been using it as a base of operations. Over 7,500 Confederate troops led by Lieutenant General Theophilus Holmes attempted to capture Helena in hopes of relieving some of the pressure on the Confederate army besieged in Vicksburg, Mississippi. Helena was defended by about 4,100 Union troops led by Major General Benjamin Prentiss, manning one fort and four batteries of artillery.