Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

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Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
EC number2.5.1.83
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC, HexPS, hexaprenyl pyrophosphate synthetase, hexaprenyl diphosphate synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units).[1][2][3] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate 3 diphosphate + all-trans-hexaprenyl diphosphate

The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate.


  1. ^ Fujii, H.; Koyama, T.; Ogura, K. (1982). "Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components". J. Biol. Chem. 257 (24): 14610–14612. PMID 7174655.
  2. ^ Shimizu, N.; Koyama, T.; Ogura, K. (1998). "Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase". J. Bacteriol. 180 (6): 1578–1581. PMC 107062. PMID 9515931.
  3. ^ Nagaki, M.; Kimura, K.; Kimura, H.; Maki, Y.; Goto, E.; Nishino, T.; Koyama, T. (2001). "Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases". Bioorg. Med. Chem. Lett. 11 (16): 2157–2159. doi:10.1016/S0960-894X(01)00391-2. PMID 11514159.

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