Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)

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Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) (EC, HexPS, (all-E) hexaprenyl diphosphate synthase, (all-trans) hexaprenyl diphosphate synthase, hexaprenyl pyrophosphate synthase, HexPPs, hexaprenyl diphosphate synthase) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units).[1][2][3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + 2 isopentenyl diphosphate 2 diphosphate + all-trans-hexaprenyl diphosphate

The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate.


  1. ^ Hemmi, H.; Ikejiri, S.; Yamashita, S.; Nishino, T. (2002). "Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus". J. Bacteriol. 184 (3): 615–620. doi:10.1128/JB.184.3.615-620.2002. PMC 139513Freely accessible. PMID 11790729. 
  2. ^ Hemmi, H.; Noike, M.; Nakayama, T.; Nishino, T. (2002). "Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations". Biochem. Biophys. Res. Commun. 297 (5): 1096–1101. doi:10.1016/S0006-291X(02)02348-3. PMID 12372398. 
  3. ^ Sun, H.Y.; Ko, T.P.; Kuo, C.J.; Guo, R.T.; Chou, C.C.; Liang, P.H.; Wang, A.H. (2005). "Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures". J. Bacteriol. 187 (23): 8137–8148. doi:10.1128/JB.187.23.8137-8148.2005. PMC 1291270Freely accessible. PMID 16291686. 

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