Highway 44 is an arterial road in central Israel. It connects Tel Aviv-Yafo and Holon to Ramla, Lod and the Shefela. It is numbered as a north–south road and follows a north-west to south-east path.

Highway 4 is an Israeli highway that runs along Israel's entire coastal plain of the Mediterranean Sea, from the Rosh HaNikra border crossing with Lebanon in the North to the Erez Border Crossing with the Gaza Strip in the South. The highway follows in part the route of the ancient Via Maris.