Holy Trinity Catholic Church is a Catholic church run by the Jesuit order that is located in the Georgetown neighborhood of Washington, D.C., in the United States. Holy Trinity Parish was founded in 1787 and is the oldest Roman Catholic community and house of worship in continuous operation both in Georgetown and in the larger city of Washington, D.C. The original church building was completed in 1794. It is now called the Chapel of St. Ignatius, and is used for smaller ecclesiastical celebrations and as an auxiliary space for parish activities. A larger church building, necessitated by the growing community, was dedicated in 1851, and still serves as the parish church today.

Francis Ignatius Neale, also known as Francis Xavier Neale, was an American Catholic priest and Jesuit who led several academic and religious institutions in Washington, D.C., and Maryland. He played a substantial role in the Jesuit order's resurgence in the United States.