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Hydrocodone, sold under the brand name Hysingla among others, is an opioid used to treat severe pain of a prolonged duration, if other measures are not sufficient. It is used as a cough suppressant in adults, it is taken by mouth. It is sold as the combinations acetaminophen/hydrocodone or ibuprofen/hydrocodone. By itself it is sold in a long-acting formulation. Common side effects include dizziness, sleepiness and constipation. Serious side effects may include abuse, low blood pressure, seizures, QT prolongation, respiratory depression, serotonin syndrome. Decreasing the dose may result in opioid withdrawal. Use during pregnancy or breastfeeding is not recommended. Hydrocodone is believed to work by activating opioid receptors in the brain and spinal cord. Hydrocodone 10 mg is equivalent to about 10 mg of morphine by mouth. Hydrocodone was patented in 1923 while the long-acting formulation was approved for medical use in the United States in 2013. In the United States the wholesale cost of the long-acting formulation is about 10 to 30 USD per dose as of 2019.

It is most prescribed in the United States, which consumed 99% of the worldwide supply as of 2010. In 2016 it was the 113th most prescribed medication in the United States with more than 6 million prescriptions, it is made from the opium poppy. Hydrocodone is used to treat moderate to severe pain. In liquid formulations, it is used to treat cough. In one study comparing the potency of hydrocodone to that of oxycodone, it was found that it took 50% more hydrocodone to achieve the same degree of miosis; the investigators interpreted this to mean. However, in a study of emergency department patients with fractures, it was found that an equal amount of either drug provided about the same degree of pain relief, indicating that there is little practical difference between them when used for that purpose; some references state that the analgesic action of hydrocodone begins in 20–30 minutes and lasts about 4–8 hours. The manufacturer's information says onset of action is about 10–30 minutes and duration is about 4–6 hours.

Recommended dosing interval is 4–6 hours. Hydrocodone is available in a variety of formulations for oral administration: The original oral form of hydrocodone alone, Dicodid, as immediate-release 5 and 10 mg tablets is available for prescription in Continental Europe per national drug control and prescription laws and Title 76 of the Schengen Treaty, but dihydrocodeine has been more used for the same indications since the beginning in the early 1920s, with hydrocodone being regulated the same way as morphine in the German Betäubungsmittelgesetz, the named law in Switzerland and the Austrian Suchtmittelgesetz, whereas dihydrocodeine is regulated like codeine. For a number of decades, the liquid hydrocodone products available are cough medicines. Hydrocodone plus homatropine in the form of small tablets for coughing and neuropathic moderate pain was more used than Dicodid and was labelled as a cough medicine in the United States whilst Vicodin and similar drugs were the choices for analgesia.

Extended-release hydrocodone in a time-release syrup containing chlorphenamine/chlorpheniramine is a cough medicine called Tussionex in North America. In Europe, similar time-release syrups containing codeine, nicocodeine, acetyldihydrocodeine and nicodicodeine are used instead. Immediate-release hydrocodone with paracetamol Immediate-release hydrocodone with ibuprofen Immediate-release hydrocodone with aspirin Controlled-release hydrocodone Hydrocodone is not available in parenteral or any other non-oral forms. Common side effects of hydrocodone are nausea, constipation, dizziness, anxiety, abnormally happy or sad mood, dry throat, difficulty urinating, rash and contraction of the pupils. Serious side effects include irregular breathing and chest tightness. Several cases of progressive bilateral hearing loss unresponsive to steroid therapy have been described as an infrequent adverse reaction to hydrocodone/paracetamol misuse; this adverse effect has been considered by some to be due to the ototoxicity of hydrocodone.

Other researchers have suggested that paracetamol is the primary agent responsible for the ototoxicity. Hydrocodone is in U. S. Food and Drug Administration pregnancy category C. No adequate and well-controlled studies in humans have been conducted. A newborn of a mother taking opioid medications prior to the birth will be physically dependent; the baby may exhibit respiratory depression if the opioid dose was high. An epidemiological study indicated that opioid treatment during early pregnancy results in increased risk of various birth defects. Symptoms of hydrocodone overdose include widened pupils. Hydrocodone can be habit forming, its abuse liability is similar to morphine and less than oxycodone. Patients consuming alcohol, other opioids, anticholinergic antihistamines, anti-psychotics, anti-anxiety agents, or other central nervous system depressants together with hydrocodone may exhibit an additi

More (Mary Alessi album)

More is a gospel album by Mary Alessi, recorded at the Covenant Church in Dallas and released on July 19, 2005. "Pastor Mike Hayes introduction" - 01:40 "Again I Say Rejoice" - 04:32 "Praise the Lord" - 04:53 "You've Made Me Glad" - 04:36 "With My Whole Heart" - 04:35 "Filled With Your Spirit" - 04:21 "So We Lift" - 08:24 "More" - 07:24 "I Worship You With All of Me" - 05:29 "Pray" - 05:33 "Another Breakthrough" - 04:24 "New Day Dawning" - 03:58 "Lord of the Breakthrough" - 05:36 "Pastor Mike Hayes Spoken Word" - 04:48 "In Him I Live" - 04:57 Aaron Lindsey - Piano, Programming & Vocals Jerry Harris - Organ and pro Tools Editing Christopher Coleman - Drums Terrance Palmer - Bass Israel Houghton - Electric & Acoustic Guitar, Lead Vocals on You've Made Me Glad" Natural - Guitar on "You've Made Me Glad" Phillip Lassiter - Horn Arrangements, Trumpet Solo Keith Jourdan - Trumpet Freddie Morgan - Trumpet Keith Anderson - Sax Tom Lauer - Sax Brad Herring - Trombone Carl Murr - Trombone Daniel Johnson - Vocals Arthur Dyer - Vocals Jamil Whiting - Vocals Lacy Edly - Vocals Stacey Joseph - Vocals Joyce Halbert - Vocals Stephanie Alessi - Vocals on "Pray" Covenant Church Choir - Vocals More peaked at #44 on Billboard magazine's Top Gospel Album.

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Caravan of Courage (TV series)

Caravan of Courage is an annual road trip, travelled by Australian comedians Hamish Blake and Andy Lee. There have been a total of four road trips, the latest two being both aired on their radio show and combined into a television special, the first two were broadcast as a segment on the talk show Rove; every Caravan of Courage takes two weeks to complete. It sees Hamish and Andy travel across numerous states or countries and meet people along the way and participate in numerous activities; the caravan is named. While visiting numerous tourist attractions and Andy take unusual routes through the smaller towns, for example in 2009, skipping the inner states of the USA. Aired as a segment of Rove rather than a stand-alone television special In 2007, the caravan of courage was thought up by Hamish and Andy who used it on their radio program, the duo wanted to have "The Peoples Holiday". Over a two-week period, they travelled 4000 km from Melbourne to Queensland, they were met in Queensland by Rove McManus and his live talk show as production moved to Queensland for the episode which feature was the caravan of courage.

Day 1: Wednesday 3 October: Southern Cross, Western Australia Day 2: Thursday 4 October: Norseman, WA Day 3: Friday 5 October: Cocklebiddy, WA Day 6: Monday 8 October: Tailem Bend, South Australia Day 7: Tuesday 9 October: Donald, Victoria Day 8: Wednesday 10 October: Benalla, VIC Day 9: Thursday 11 October: Goulburn, New South Wales Day 10: Friday 12 October: Bulahdelah, NSW In 2008, after being taunted by emails claiming they did not travel far enough. Hamish and Andy after first rejecting the idea decided they would once again bring out the caravan and set out from Melbourne to Darwin in two weeks, they set out on 27 October 2008. The trip was named "Who Dares Dar-Wins" a parodied title of the popular Australian show Who Dares Wins. Day 1: Nhill, Victoria Day 2: Williamstown, South Australia Day 3: Hawker, South Australia Day 4: Roxby Downs, South Australia Day 5: Coober Pedy, South Australia Day 6: Yulara, Northern Territory Day 7: Aileron, Northern Territory Day 8: Wycliffe Well, Northern Territory Day 9: Elliot, Northern Territory Day 10: Mataranka, Northern Territory Day 11: Pine Creek, Northern Territory Day 12: Jabiru, Kakadu National Park, Northern Territory Day 13: Darwin, Northern Territory Hamish & Andy's American Caravan of Courage was the third installment in the Caravan of Courage franchise.

The road trip was travelled by Australian comedy duo Hamish and Andy and their caravan called Abravan Lincoln. The two-week adventure was aired on their radio show and was made into a television special for the Australian Network Ten. Hamish and Andy travelled 5,000 km from Miami to L. A. in their caravan Abravan Lincoln. The trip aired on Australian radio every weekday as part of their program The Hamish & Andy Show which streams across numerous radio stations across Australia. Parts of the trip were combined and aired as a special on Network Ten Before Hamish Blake and Andy Lee left for their caravan of courage, the two of them'Caraplaned' their trip; the title of the trip was decided to be called "Yes We Van", nominees were "We Come From A Van Down Under", "The United States of Ameri-Caravan" and "RV There Yet?". Trip: Day 1 – Hamish and Andy arrive at their first stop in Miami, Florida as Hamish takes a driving licence test, they locate a voodoo doll store and Hamish and Andy hunt down crocodiles with a local man.

Day 2 – On their second day Hamish and Andy took a College'Frat' welcoming ceremony, tried to track down the mythological Skunk Ape and accidentally ran over a historical tree, important to the local people. Day 3 – The duo arrive in Alabama where Hamish goes swimming with mermaids and Andy is placed under arrest by the local Sheriff Bubba and his side-kick Hamish and they find out how dirty dirt bike riding can be. Day 4 – On their fourth day they arrive in Mississippi and visit the town Laurel and attempt the local past times which are shooting, chewing tobacco and eating large slices of food and find out what happens after you shout at ghosts. Day 5 – Remaining in the state of Mississippi and Andy have a go at the local sport of Anvil Shooting, learn to sing the style of blues and provide a guided tour of the infamous Abravan Lincoln caravan Day 6 & 7 – The duo arrive in Texas and Andy receives a broken nose from a game of Gridiron from a sixteen-year-old high school player and Hamish trains and becomes a cheerleader and they both start a pep rally.

Day 8 – The team arrive in New Mexico at a local township known as alien central of America. They meet people who claim they have been abducted by extra terrestrials from other planets and they have a party with a group of cowboys. Day 9 – On their ninth day on their caravan of courage in New Mexico Andy starts a war against Hamish and they visit a Shop that sells rocks and Hamish is happy when he decides to purchase a miniature horse. Day 10 – The two arrive in Arizona and have a Show Low as'Arizona Andy' challenges Hamish for making the caravan have a foul odor with his constant farting and burping and they gamble in a casino with a local. Day 11 – On their eleventh day in the United States and Andy create an involvement in the mystical Mountain magic and living their American dream by visiting the great oversized American supermarket. Day 12 – Hamish and Andy have made their way to Las Vegas where they gamble with the money raised from their the peoples $1000 bet to be able to afford a'real life' hoverboard from an online website.

Day 13 – On their final day of their American caravan of courage and Andy party in the big apple, New York City with a group of listeners from all over of Australia with Hamish having too mu

Take Wing

Take Wing was an American Thoroughbred gelding racehorse claimed for $3,000 and who would earn more than $160,000 for new owner Clyde Troutt and set a new North American record for a mile and three-sixteenths on turf. Take Wing was sired by Chicle, the Leading sire in North America in 1929 and the Leading broodmare sire in North America in 1942. Take Wing's dam was a daughter of a multiple race winning full brother to Man o' War. Trainer Clyde Troutt claimed Take Wing in early July 1942 and won the Stars and Stripes Handicap at Arlington Park in a time, just 1/5 of a second off the track record. For his win, the $3000 horse earned his new owner $8,600. Still racing at age nine, Take Wing set a new North American record of 1:55 1-5 for a mile and three-sixteenths on turf at Washington Park Racetrack in winning the Meadowland Handicap for the third time. Following his retirement from racing, Take wing was used as a lead pony for owner-trainer Clyde Troutt

Illusion of Gaia

Illusion of Gaia, known in Europe and Australia as Illusion of Time, is an action role-playing game developed by Quintet for the Super Nintendo Entertainment System. While Illusion of Gaia has a large cast of characters, Will and Shadow are the only playable characters in the game, they each have unique abilities, certain areas are impassable without a specific character. The characters gain techniques as part of the story. Will's techniques are all based on reaching new areas with incidental combat applications, while Freedan's techniques are more combat-oriented. Shadow arrives late in the game, but being such a powerful character, he causes Freedan to be nearly obsolete. Combat is simple. Characters have different levels of strength. Freedan, for example, does noticeably more damage, has a longer reach than Will. In turn, Shadow does more damage than Freedan. Attacks are exclusively melee, using Will's flute, Freedan's sword or Shadow's pseudopod. Enemies' health bars appear upon attacking, displaying as a series of red spheres that represent hit points.

Bosses cannot be revisited, enemies do not reappear unless Will loses all his lives or exits an area and returns. Illusion of Gaia has a general design, uniquely simple as RPGs go; the game eschews the experience system of typical role-playing video games. Defeating all enemies in a room earns the player a permanent stat bonus in the form of a jewel; these jewels boost defense or health power. While returning to a cleared area will cause enemies to reappear, the bonuses for defeating them again do not. After an enemy is killed, it will leave a stone—either a small or a great one. Collecting 100 of these allows the player character to restart closer to where they died with all enemies still defeated, by earning a new life; the game has no currency or equipment systems. There is only one healing item, only a small number of those in the game. Unlike most games of its type visited areas are most blocked off, except that areas within the last third of the game can be revisited; the only sidequest in the game, finding Red Jewels, thus becomes impossible to complete if the player fails to find them before advancing the story.

Like most RPGs of the time, the game has only one difficulty setting. Saving is accomplished at Dark Spaces located throughout each level—including areas without enemies, such as Will's hometown. Will can recover lost health within the Dark Spaces, switch forms or gain new abilities. Illusion of Gaia is set in a historical but fantasy-based version of Earth; the game contains several real-world sites, such as Incan ruins, the Nazca Lines, Angkor Wat, the Great Wall of China and the Egyptian pyramids. Each of these ruins hold a piece to the final puzzle, unveiled at the top of the infamous Tower of Babel, it is firstly believed to be the age of exploration, explorers have begun scouring the world in search of ancient ruins and the lost treasures and secrets within. Many return with nothing, some are never seen again. Will, the protagonist of the game, is a survivor of one such ill-fated expedition, he accompanied his father, a famed explorer, on a sea journey to uncover the secrets of the Tower of Babel, but the explorers met with a mysterious disaster.

Somehow Will managed to make it back to his hometown. When the game begins, Will stumbles into a "Dark Space". Gaia tells Will that he must save the world from a coming evil. A comet is approaching, it will bring ill fortune to the world; as he travels, Will gains the ability to change into other forms, each with special powers: Freedan, a dark knight, Shadow, a solid form of energy. It is revealed that the comet is in fact an ancient weapon used during the last Blazer War, has the power to change the shape of the world. In the ruin of Angkor Wat, it is discovered that the comet's repeated approach and effect on the Earth has prevented the world and humanity from evolving into a more modern state. Will and his friends collect artifacts known as Mystic Statues. At the climax and Kara reach the Tower of Babel, where it is revealed that Will is the Dark Knight, Kara is the Light Knight; the two knights join to form Shadow and use the ancient statues to release the ultimate power, the firebird. Attacking the comet directly, which soon manifests itself as Dark Gaia and Kara manage to destroy its power, returning the world to normal.

The spirits of Will's parents inform them that the world will return to normal and that no one will conserve any memories of the adventure. Saddened by that fact and Kara join one last time as Shadow to return to Earth; the final scene is left ambiguous. All of Will's friends are depicted in what appears to be a modern-day school, implying that if they forgot about their time together, they remained friends in the "real" world. Illusion of Gaia features only one playable character at a time: either Will, a boy who develops psychic powers after surviving a shipwreck during an exploratory expedition with his father, or his alter egos Freedan and Shadow. However, a large group of non-player characters accompany Will from region to region. Illusion of Gaia was scored by Yasuhiro Kawasaki. Moto Hagio, the influential manga artist, is credited with the character designs. Novelist Mariko Ōhara worked on the story; the game is considered an unofficial trilogy along with two other Quinet de

Claudia Geiringer

Claudia Geiringer is a New Zealand professor of law. Geiringer did an LLB at Victoria University of Wellington, a BA at the University of Otago and a LLM at Columbia Law School in New York City as a Fulbright Scholar, an Ethel Benjamin Scholar and a James Kent Scholar. From 1996-2001 Geiringer work as Crown Counsel in the Bill of Rights team at the Crown Law Office, she received Marsden funding in the 2013 round. Seeing the world whole: essays in honour of Sir Kenneth Keith What's the hurry?: urgency in the New Zealand legislative process 1987-2010 The Dead Hand of the Bill of Rights?: Is the New Zealand Bill of Rights Act 1990 a Substantive Legal Constraint on Parliament's Power to Legislate?, Otago Law Review, 2005 On a Road to Nowhere: Implied Declarations of Inconsistency and the New Zealand Bill of Rights Act, Victoria University of Wellington Law Review, 2009 Historical background to the Muriwhenua Land Claim, 1865–1950, Report for the Waitangi Tribunal, 1992 google scholar institutional homepage