Hydroperoxide dehydratase

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hydroperoxide dehydratase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a hydroperoxide dehydratase (EC is an enzyme that catalyzes the chemical reaction

(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O

Hence, this enzyme has one substrate, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and two products, (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]. Other names in common use include hydroperoxide isomerase, linoleate hydroperoxide isomerase, linoleic acid hydroperoxide isomerase, HPI, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and 12,13-hydro-lyase.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U5U.


  • Esselman WJ, Clagett CO (1974). "Products of linoleic hydroperoxide-decomposing enzyme of alfalfa seed". J. Lipid Res. 15 (2): 173–8. PMID 4208994. 
  • Hamberg M (1987). "Mechanism of corn hydroperoxide isomerase - detection of 12,13(S)-oxido-9(Z),11-octadecadienoic acid". Biochim. Biophys. Acta. 920: 76–84. doi:10.1016/0005-2760(87)90313-4. 
  • Hamberg M (1988). "Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase". Biochem. Biophys. Res. Commun. 156 (1): 543–50. doi:10.1016/S0006-291X(88)80876-3. PMID 3178850.