Hydroxymethylglutaryl-CoA hydrolase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
hydroxymethylglutaryl-CoA hydrolase
Identifiers
EC number 3.1.2.5
CAS number 9025-89-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a hydroxymethylglutaryl-CoA hydrolase (EC 3.1.2.5) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O CoA + 3-hydroxy-3-methylglutarate

Thus, the two substrates of this enzyme are (S)-3-hydroxy-3-methylglutaryl-CoA and H2O, whereas its two products are CoA and 3-hydroxy-3-methylglutarate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is (S)-3-hydroxy-3-methylglutaryl-CoA hydrolase. Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase, beta-hydroxy-beta-methylglutaryl coenzyme A deacylase, hydroxymethylglutaryl coenzyme A hydrolase, hydroxymethylglutaryl coenzyme A deacylase, and 3-hydroxy-3-methylglutaryl-CoA hydrolase.

References[edit]

  • DEKKER EE, SCHLESINGER MJ, COON MJ (1958). "beta-Hydroxy-beta-methylglutaryl coenzyme A deacylase". J. Biol. Chem. 233 (2): 434–8. PMID 13563516.