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Clinical data
Synonyms OH-NEF
Pharmacokinetic data
Elimination half-life 1.5–4 hours[1]
CAS Number
PubChem CID
Chemical and physical data
Formula C25H32ClN5O3
Molar mass 486.013 g/mol
3D model (JSmol)

Hydroxynefazodone is a phenylpiperazine compound and a major metabolite of the antidepressant nefazodone.[1][2][3] It has similar biological activity and a similar elimination half-life (1.5 to 4 hours)[1] to those of nefazodone, and may contribute significantly to its effects.[2][3]

See also[edit]


  1. ^ a b c Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. (2017). The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. pp. 460–. ISBN 978-1-58562-523-9. 
  2. ^ a b Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross (6 December 2012). Antidepressants: Past, Present and Future. Springer Science & Business Media. pp. 68–. ISBN 978-3-642-18500-7. 
  3. ^ a b Davis R, Whittington R, Bryson HM (1997). "Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression". Drugs. 53 (4): 608–36. PMID 9098663.