European Chemicals Agency
ECHA is the driving force among regulatory authorities in implementing the EUs chemicals legislation. ECHA helps companies to comply with the legislation, advances the safe use of chemicals, provides information on chemicals and it is located in Helsinki, Finland. The Agency, headed by Executive Director Geert Dancet, started working on 1 June 2007, the REACH Regulation requires companies to provide information on the hazards and safe use of chemical substances that they manufacture or import. Companies register this information with ECHA and it is freely available on their website. So far, thousands of the most hazardous and the most commonly used substances have been registered, the information is technical but gives detail on the impact of each chemical on people and the environment. This gives European consumers the right to ask whether the goods they buy contain dangerous substances. The Classification and Packaging Regulation introduces a globally harmonised system for classifying and labelling chemicals into the EU.
This worldwide system makes it easier for workers and consumers to know the effects of chemicals, companies need to notify ECHA of the classification and labelling of their chemicals. So far, ECHA has received over 5 million notifications for more than 100000 substances, the information is freely available on their website. Consumers can check chemicals in the products they use, Biocidal products include, for example, insect repellents and disinfectants used in hospitals. The Biocidal Products Regulation ensures that there is information about these products so that consumers can use them safely. ECHA is responsible for implementing the regulation, the law on Prior Informed Consent sets guidelines for the export and import of hazardous chemicals. Through this mechanism, countries due to hazardous chemicals are informed in advance and have the possibility of rejecting their import. Substances that may have effects on human health and the environment are identified as Substances of Very High Concern 1.
These are mainly substances which cause cancer, mutation or are toxic to reproduction as well as substances which persist in the body or the environment, other substances considered as SVHCs include, for example, endocrine disrupting chemicals. Companies manufacturing or importing articles containing these substances in a concentration above 0 and they are required to inform users about the presence of the substance and therefore how to use it safely. Consumers have the right to ask the retailer whether these substances are present in the products they buy, once a substance has been officially identified in the EU as being of very high concern, it will be added to a list. This list is available on ECHA’s website and shows consumers and industry which chemicals are identified as SVHCs, Substances placed on the Candidate List can move to another list
They act by blocking the progesterone receptor and/or inhibiting or suppressing progestogen production. Antiprogestogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiandrogens, antiprogestogens are used as abortifacients and emergency contraceptives and in the treatment of uterine fibroids. They are being studied in the treatment of breast cancer, for medical abortion, mifepristone is combined with a prostaglandin. Antiprogestin entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material from the U. S. National Cancer Institute document Dictionary of Cancer Terms
Monaco, officially the Principality of Monaco, is a sovereign city-state and microstate, located on the French Riviera in Western Europe. France borders the country on three sides while the other side borders the Mediterranean Sea, Monaco has an area of 2.02 km2 and a population of about 38,400 according to the last census of 2015. With 19,009 inhabitants per km², it is the second smallest, Monaco has a land border of 5.47 km, a coastline of 3.83 km, and a width that varies between 1,700 and 349 m. The highest point in the country is a pathway named Chemin des Révoires on the slopes of Mont Agel, in the Les Révoires Ward. Monacos most populous Quartier is Monte Carlo and the most populous Ward is Larvotto/Bas Moulins, through land reclamation, Monacos land mass has expanded by twenty percent, in 2005, it had an area of only 1.974 km2. Monaco is known as a playground for the rich and famous, in 2014, it was noted about 30% of the population was made up of millionaires, more than in Zürich or Geneva.
Monaco is a principality governed under a form of constitutional monarchy, although Prince Albert II is a constitutional monarch, he wields immense political power. The House of Grimaldi have ruled Monaco, with brief interruptions, the official language is French, but Monégasque and English are widely spoken and understood. The states sovereignty was recognized by the Franco-Monegasque Treaty of 1861. Despite Monacos independence and separate foreign policy, its defense is the responsibility of France, Monaco does maintain two small military units. Economic development was spurred in the late 19th century with the opening of the countrys first casino, Monte Carlo, since then, Monacos mild climate and gambling facilities have contributed to the principalitys status as a tourist destination and recreation center for the rich. In more recent years, Monaco has become a major banking center and has sought to diversify its economy into services and small, high-value-added, the state has no income tax, low business taxes, and is well known for being a tax haven.
It is the host of the street circuit motor race Monaco Grand Prix. Monaco is not formally a part of the European Union, but it participates in certain EU policies, including customs, through its relationship with France, Monaco uses the euro as its sole currency. Monaco joined the Council of Europe in 2004 and it is a member of the Organisation Internationale de la Francophonie. Monacos name comes from the nearby 6th-century BC Phocaean Greek colony, according to an ancient myth, Hercules passed through the Monaco area and turned away the previous gods. As a result, a temple was constructed there, the temple of Hercules Monoikos, because the only temple of this area was the House of Hercules, the city was called Monoikos. It ended up in the hands of the Holy Roman Empire, an ousted branch of a Genoese family, the Grimaldi, contested it for a hundred years before actually gaining control
Tocopherols are a class of organic chemical compounds, many of which have vitamin E activity. Tocotrienols, which are related compounds, have vitamin E activity, Vitamin E exists in eight different forms, four tocopherols and four tocotrienols. All feature a ring, with a hydroxyl group that can donate a hydrogen atom to reduce free radicals. Both the tocopherols and tocotrienols occur in α, β, γ and δ forms, determined by the number, the unsaturation of the tails gives tocotrienols only a single stereoisomeric carbon, whereas tocopherols have 3 centers. Each form has a different biological activity, in general, the unnatural l-isomers of tocotrienols lack almost all vitamin activity, and half of the possible 8 isomers of the tocopherols lack vitamin activity. Of the stereoisomers which retain activity, increasing methylation, especially full methylation to the alpha-form, in tocopherols, this is due to the preference of the tocopherol binding protein for the alpha-tocopherol form of the vitamin.
As a food additive, tocopherol is labeled with these E numbers, E306, E307, E308 and these are all approved in the USA, EU and Australia and New Zealand for use as antioxidants. Alpha-tocopherol is the form of vitamin E that is absorbed and accumulated in humans. The measurement of vitamin E activity in units was based on fertility enhancement by the prevention of miscarriages in pregnant rats relative to alpha-tocopherol. There are three stereocenters in alpha-tocopherol, so this is a chiral molecule, the eight stereoisomers of alpha-tocopherol differ in the arrangement of groups around these stereocenters. In the image of RRR-alpha-tocopherol below, all three stereocenters are in the R form, however, if the middle of the three stereocenters were changed, this would become the structure of RSR-alpha-tocopherol. These stereoisomers can be named in an alternative older nomenclature,1 IU of tocopherol is defined as ⅔ milligrams of RRR-alpha-tocopherol. 1 IU is defined as 1 milligram of a mix of the eight stereoisomers.
This mix of stereoisomers is often called dl-alpha-tocopheryl acetate, even though it is more precisely dl, dl, although less commonly known, belong to the vitamin E family. Tocotrienols have four natural 2 d-isomers, tocotrienol has been subject to fewer clinical studies and seen less research as compared to tocopherol. However, there is growing interest in the effects of these compounds. During feeding experiments with rats Herbert McLean Evans concluded in 1922 that besides vitamins B and C, although every other nutrition was present, the rats were not fertile. This condition could be changed by additional feeding with wheat germ and it took several years until 1936 when the substance was isolated from wheat germ and the formula C29H50O2 was determined
These are limited to a single typographic line of symbols, which may include subscripts and superscripts. A chemical formula is not a name, and it contains no words. Although a chemical formula may imply certain simple chemical structures, it is not the same as a full chemical structural formula. Chemical formulas can fully specify the structure of only the simplest of molecules and chemical substances, the simplest types of chemical formulas are called empirical formulas, which use letters and numbers indicating the numerical proportions of atoms of each type. Molecular formulas indicate the numbers of each type of atom in a molecule. For example, the formula for glucose is CH2O, while its molecular formula is C6H12O6. This is possible if the relevant bonding is easy to show in one dimension, an example is the condensed molecular/chemical formula for ethanol, which is CH3-CH2-OH or CH3CH2OH. For reasons of structural complexity, there is no condensed chemical formula that specifies glucose, chemical formulas may be used in chemical equations to describe chemical reactions and other chemical transformations, such as the dissolving of ionic compounds into solution. A chemical formula identifies each constituent element by its chemical symbol, in empirical formulas, these proportions begin with a key element and assign numbers of atoms of the other elements in the compound, as ratios to the key element.
For molecular compounds, these numbers can all be expressed as whole numbers. For example, the formula of ethanol may be written C2H6O because the molecules of ethanol all contain two carbon atoms, six hydrogen atoms, and one oxygen atom. Some types of compounds, cannot be written with entirely whole-number empirical formulas. An example is boron carbide, whose formula of CBn is a variable non-whole number ratio with n ranging from over 4 to more than 6.5. When the chemical compound of the consists of simple molecules. These types of formulas are known as molecular formulas and condensed formulas. A molecular formula enumerates the number of atoms to reflect those in the molecule, so that the formula for glucose is C6H12O6 rather than the glucose empirical formula. However, except for very simple substances, molecular chemical formulas lack needed structural information, for simple molecules, a condensed formula is a type of chemical formula that may fully imply a correct structural formula.
For example, ethanol may be represented by the chemical formula CH3CH2OH
International Standard Book Number
The International Standard Book Number is a unique numeric commercial book identifier. An ISBN is assigned to each edition and variation of a book, for example, an e-book, a paperback and a hardcover edition of the same book would each have a different ISBN. The ISBN is 13 digits long if assigned on or after 1 January 2007, the method of assigning an ISBN is nation-based and varies from country to country, often depending on how large the publishing industry is within a country. The initial ISBN configuration of recognition was generated in 1967 based upon the 9-digit Standard Book Numbering created in 1966, the 10-digit ISBN format was developed by the International Organization for Standardization and was published in 1970 as international standard ISO2108. Occasionally, a book may appear without a printed ISBN if it is printed privately or the author does not follow the usual ISBN procedure, this can be rectified later. Another identifier, the International Standard Serial Number, identifies periodical publications such as magazines, the ISBN configuration of recognition was generated in 1967 in the United Kingdom by David Whitaker and in 1968 in the US by Emery Koltay.
The 10-digit ISBN format was developed by the International Organization for Standardization and was published in 1970 as international standard ISO2108, the United Kingdom continued to use the 9-digit SBN code until 1974. The ISO on-line facility only refers back to 1978, an SBN may be converted to an ISBN by prefixing the digit 0. For example, the edition of Mr. J. G. Reeder Returns, published by Hodder in 1965, has SBN340013818 -340 indicating the publisher,01381 their serial number. This can be converted to ISBN 0-340-01381-8, the check digit does not need to be re-calculated, since 1 January 2007, ISBNs have contained 13 digits, a format that is compatible with Bookland European Article Number EAN-13s. An ISBN is assigned to each edition and variation of a book, for example, an ebook, a paperback, and a hardcover edition of the same book would each have a different ISBN. The ISBN is 13 digits long if assigned on or after 1 January 2007, a 13-digit ISBN can be separated into its parts, and when this is done it is customary to separate the parts with hyphens or spaces.
Separating the parts of a 10-digit ISBN is done with either hyphens or spaces, figuring out how to correctly separate a given ISBN number is complicated, because most of the parts do not use a fixed number of digits. ISBN issuance is country-specific, in that ISBNs are issued by the ISBN registration agency that is responsible for country or territory regardless of the publication language. Some ISBN registration agencies are based in national libraries or within ministries of culture, in other cases, the ISBN registration service is provided by organisations such as bibliographic data providers that are not government funded. In Canada, ISBNs are issued at no cost with the purpose of encouraging Canadian culture. In the United Kingdom, United States, and some countries, where the service is provided by non-government-funded organisations. Australia, ISBNs are issued by the library services agency Thorpe-Bowker
While Jmol has many features that Chime lacks, it does not claim to reproduce all Chime functions, most notably, Chime requires plug-in installation and Internet Explorer 6.0 or Firefox 2.0 on Microsoft Windows, or Netscape Communicator 4.8 on Mac OS9. Jmol requires Java installation and operates on a variety of platforms. For example, Jmol is fully functional in Mozilla Firefox, Internet Explorer, Google Chrome and Scriptable Molecular Graphics in Web Browsers without Java3D
International Standard Serial Number
An International Standard Serial Number is an eight-digit serial number used to uniquely identify a serial publication. The ISSN is especially helpful in distinguishing between serials with the same title, ISSN are used in ordering, interlibrary loans, and other practices in connection with serial literature. The ISSN system was first drafted as an International Organization for Standardization international standard in 1971, ISO subcommittee TC 46/SC9 is responsible for maintaining the standard. When a serial with the content is published in more than one media type. For example, many serials are published both in print and electronic media, the ISSN system refers to these types as print ISSN and electronic ISSN, respectively. The format of the ISSN is an eight digit code, divided by a hyphen into two four-digit numbers, as an integer number, it can be represented by the first seven digits. The last code digit, which may be 0-9 or an X, is a check digit. Formally, the form of the ISSN code can be expressed as follows, NNNN-NNNC where N is in the set, a digit character.
The ISSN of the journal Hearing Research, for example, is 0378-5955, where the final 5 is the check digit, for calculations, an upper case X in the check digit position indicates a check digit of 10. To confirm the check digit, calculate the sum of all eight digits of the ISSN multiplied by its position in the number, the modulus 11 of the sum must be 0. There is an online ISSN checker that can validate an ISSN, ISSN codes are assigned by a network of ISSN National Centres, usually located at national libraries and coordinated by the ISSN International Centre based in Paris. The International Centre is an organization created in 1974 through an agreement between UNESCO and the French government. The International Centre maintains a database of all ISSNs assigned worldwide, at the end of 2016, the ISSN Register contained records for 1,943,572 items. ISSN and ISBN codes are similar in concept, where ISBNs are assigned to individual books, an ISBN might be assigned for particular issues of a serial, in addition to the ISSN code for the serial as a whole.
An ISSN, unlike the ISBN code, is an identifier associated with a serial title. For this reason a new ISSN is assigned to a serial each time it undergoes a major title change, separate ISSNs are needed for serials in different media. Thus, the print and electronic versions of a serial need separate ISSNs. Also, a CD-ROM version and a web version of a serial require different ISSNs since two different media are involved, the same ISSN can be used for different file formats of the same online serial