Hydroxyprogesterone heptanoate

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Hydroxyprogesterone heptanoate
Hydroxyprogesterone heptanoate.svg
Clinical data
Trade names H.O.P, Lutogil A.P., Lutogyl A.P.
Synonyms Hydroxyprogesterone enanthate; 17α-Hydroxyprogesterone heptanoate; 17α-Hydroxypregn-4-ene-3,20-dione 17α-heptanoate
Routes of
Intramuscular injection
Drug class Progestin; Progestogen; Progestogen ester
ATC code
CAS Number
PubChem CID
ECHA InfoCard 100.022.724 Edit this at Wikidata
Chemical and physical data
Formula C28H42O4
Molar mass 442.631 g/mol
3D model (JSmol)

Hydroxyprogesterone heptanoate (brand names H.O.P., Lutogil A.P., Lutogyl A.P.), or 17α-hydroxyprogesterone heptanoate, also known as hydroxyprogesterone enanthate,[1] is a progestin of the 17α-hydroxyprogesterone group which was developed by Roussel and Théramex and has been used clinically in France and Monaco.[2][3][4][5] It was a component of the experimental preparation Trophoboline (or Trophobolene), which also contained nandrolone decanoate and estrapronicate.[6][7][8] It was also studied or used in Tocogestan, a combination of hydroxyprogesterone heptanoate (200 mg), progesterone (50 mg), and tocopherol (250 mg) oil for intramuscular injection.[9][5][10]


See also[edit]


  1. ^ Batres, E.; Gomez, R.; Rosenkranz, G.; Sondheimer, F. (1956). "Notes - Steroids. LXXVI. Synthesis of Long Chain Carboxylic Acid Esters of 17α-Hydroxyprogesterone". The Journal of Organic Chemistry. 21 (2): 240–241. doi:10.1021/jo01108a601. ISSN 0022-3263. 
  2. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 665–. ISBN 978-1-4757-2085-3. 
  3. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 532–. ISBN 978-3-88763-075-1. 
  4. ^ Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 612–. ISBN 978-3-7692-2114-5. 
  5. ^ a b Axel Kleemann; Jürgen Engel (2001). Pharmaceutical Substances: Syntheses, Patents, Applications. Thieme. p. 1033. ISBN 978-3-13-558404-1. 
  6. ^ Excerpta medica. Section 8, Neurology and neurosurgery. 1981. p. 10. 
  7. ^ Testosterone Congeners—Advances in Research and Application: 2013 Edition: ScholarlyBrief. ScholarlyEditions. 21 June 2013. pp. 137–. ISBN 978-1-4816-9288-5. 
  8. ^ Alberto Frigerio (1981). Chromatography in Biochemistry, Medicine and Environmental Research: Proceedings of the ... International Symposium on Chromatography in Biochemistry, Medicine and Environmental Research. Elsevier Scientific Publishing Company. p. 99. 
  9. ^ https://www.google.com/patents/US6774122
  10. ^ http://content.iospress.com/articles/international-journal-of-risk-and-safety-in-medicine/jrs132