IRF2

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
IRF2
Protein IRF2 PDB 1irf.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIRF2, IRF-2, interferon regulatory factor 2
External IDsMGI: 96591 HomoloGene: 1659 GeneCards: IRF2
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for IRF2
Genomic location for IRF2
Band4q35.1Start184,387,713 bp[1]
End184,474,580 bp[1]
RNA expression pattern
PBB GE IRF2 203275 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002199

NM_008391

RefSeq (protein)

NP_002190

NP_032417

Location (UCSC)Chr 4: 184.39 – 184.47 MbChr 8: 46.74 – 46.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.[5]

Function[edit]

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.[6]

See also[edit]

Interactions[edit]

IRF2 has been shown to interact with BRD7,[7] EP300[8] and PCAF.[8][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168310 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031627 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (September 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell. 58 (4): 729–39. doi:10.1016/0092-8674(89)90107-4. PMID 2475256. 
  6. ^ "Entrez Gene: IRF2 interferon regulatory factor 2". 
  7. ^ Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449. 
  8. ^ a b Masumi A, Ozato K (June 2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. 276 (24): 20973–80. doi:10.1074/jbc.M101707200. PMID 11304541. 
  9. ^ Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (March 1999). "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. PMC 83974Freely accessible. PMID 10022868. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.