An imidazopyridine is a nitrogen containing heterocycle, a class of drugs that contain this same chemical substructure. In general, they are GABAA receptor agonists, however proton pump inhibitors, aromatase inhibitors, NSAIDs and other classes of drugs in this class have been developed as well. Despite being similar to them in effect, they are not chemically related to benzodiazepines; as such, GABAA-agonizing imidazopyridines, pyrazolopyrimidines, cyclopyrrones are sometimes grouped together and referred to as "nonbenzodiazepines." Imidazopyridines include: Anxiolytics and hypnotics: Imidazopyridines: Alpidem —an anxiolytic, withdrawn from the market worldwide in 1995 due to hepatotoxicity. DS-1—a GABAA receptor positive allosteric modulator selective for the α4β3δ subtype, not targeted by other GABAergics such as benzodiazepines or other nonbenzodiazepines. Necopidem—an anxiolytic, it has not found clinical use. Saripidem—a sedative and anxiolytic, it is not used clinically. TP-003—a subtype-selective partial agonist at GABAA receptors, binding to GABAA receptor complexes bearing either α2, α3 or α5 subunits, but only showing significant efficacy at α3.
Zolpidem —a used hypnotic. Generic versions are available. Imidazopyridines: Bamaluzole—a GABAA receptor-agonizing anticonvulsant, never marketed. Antipsychotics: Imidazopyridines: Mosapramine —an atypical antipsychotic used in Japan. Drugs used for peptic ulcer disease, GERD and gastroprokinetic agents: Imidazopyridines: CJ-033466—an experimental gastroprokinetic acting as a selective 5-HT4 serotonin receptor partial agonist. Zolimidine—a gastroprotective agent. Linaprazan—a potassium-competitive acid blocker which demonstrated similar efficacy as esomeprazole in healing and controlling symptoms of GERD patients with erosive esophagitis. SCH28080—the prototypical potassium-competitive acid blocker which has not found clinical use because of liver toxicity in animal trials and elevated liver enzyme activity in the serum of human volunteers. Imidazopyridines: Tenatoprazole—it blocks the gastric proton pump leading to decline of gastric acid production. NSAIDs, analgesics and antimigraine drugs: Imidazopyridines: Miroprofen—a derivative of propionic acid.
Imidazopyridines: Telcagepant—a calcitonin gene-related peptide receptor antagonist, in clinical trials as a remedy for migraine. Its development was terminated. Drugs acting on the cardiovascular system: Imidazopyridines: Olprinone —a cardiac stimulant. Drugs for treatment of bone diseases: Imidazopyridines: Minodronic acid —a third-generation bisphosphonate used for the treatment of osteoporosis. Antineoplastic agents: Imidazopyridines: Fadrozole —an aromatase inhibitor. Imidazopyridines: 3-Deazaneplanocin A—an S-adenosyl-L-homocysteine synthesis inhibitor and histone methyltransferase EZH2 inhibitor. Directly-acting antiviral agents: Imidazopyridines: Tegobuvir/GS-9190 - an allosteric, non-nucleoside hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor targeting the thumb II allosteric site. Media related to Imidazopyridines at Wikimedia Commons
Jonas R. McClintock, served as Mayor of Pittsburgh from 1836 to 1839, he was the first Medical Doctor. Jonas Roup McClintock was born in Pennsylvania in 1808, he graduated from the University of Pittsburgh. He attended the University of Maryland Medical School, earning an M. D. in 1830. He rose to local fame heroically treating his fellow Pittsburghers during the cholera epidemics in the early 1830s. In 1832 he organized Pittsburgh's first board of health, he was a member of the local vigilance committee and the volunteer fire company. At the youthful age of 28 he became mayor, much on his fame and legend making the city safe from cholera and fire earlier in the decade, he was known affectionately as the "Boy Mayor". His mayoral administration had to deal with hard financial times in the late 1830s. However, he succeeded in major infrastructure improvements in the city including the original "cut" of Grant's Hill, a steep bluff boxing the city in on the east; the "cut" allowed for settlement of an area of the city uninhabitable because of the grade of the land.
Upon leaving the mayor's office, McClintock ran for state Senator in 1853. His stay in Harrisburg was highlighted by his championing of commonwealth legislation promoting free secondary education; when the U. S. Civil War divided the nation, Dr. McClintock help organize a troop company for battle, it numbered over 3,500 men. In 1879 he died from a strangulated hernia, he was buried in Allegheny Cemetery. List of Mayors of Pittsburgh
Lockheed PV-2 Harpoon, U. S. Navy Bureau Number 37396, civil registration N7265C, named "Hot Stuff", is located at 3867 N. Aviation Way, Mount Comfort, Indiana; the aircraft, an intact example of a World War II anti-submarine patrol bomber, was added to the National Register of Historic Places on April 23, 2009. It was built in 1945 by the Lockheed Aircraft Corporation, is one of only 104 built of this PV-2 variant of the Lockheed Ventura. At the time of its listing, it was the only complete, operable example of a PV-2 in the United States, although one was being restored in Wisconsin. While this particular plane did not see combat, the type was used in the Aleutian Islands during World War II; the property was the featured listing in the National Park Service's weekly list of May 1, 2009. Lockheed Ventura National Register of Historic Places Registration Form for this aircraft
Rainford railway station is situated to the north of the village of Rainford, England. It is on the Kirkby branch line; the station, all trains serving it, are operated by Northern. It was built in 1858 as Rainford Junction at the junction of the Liverpool and Bury Railway, the East Lancashire Railway's Skelmersdale Branch and the St. Helens Railway, replacing an earlier station called Rainford; the main line and Skelmersdale branch were taken over by the Lancashire and Yorkshire Railway in 1859, whilst the St Helens line became part of the London and North Western Railway in 1864. The former L&BR route was subsequently upgraded by the L&YR to become its main line between Liverpool and Manchester, carrying expresses to Manchester Victoria, Bradford Exchange and Leeds Central as well as local trains to Wigan Wallgate and Bolton until after the nationalisation of the railways in 1948 and well beyond. Services on the line to St Helens were withdrawn by the British Transport Commission on 18 June 1951 and to Ormskirk on 5 November 1956, although goods traffic survived on both until the early 1960s.
Through trains from Liverpool Exchange to Bolton via Wigan continued until 1977, though the line from here westwards to Fazakerley had been reduced to single track operation in May 1970. After the closure of Exchange in May 1977, the line was severed at Kirkby, with through passengers having to change between diesel and electric services there to continue their journeys; the station signal box was retained to supervise the 5 1⁄4 miles single line section to what was now the terminus of the branch – this remains in operation today and is now the only one left on the line. The station was renamed Rainford on 7 May 1973. Though the station had sizeable buildings on both platforms at one time, the last of these was demolished in the late 1990s. There are now just basic shelters in place on each side, along with a footbridge to connect them; the disused branch platform faces are still visible, but overgrown. The station is unmanned and has no ticket facilities, so all tickets must be bought in advance or on the train.
Train running information can be obtained by telephone or from timetable poster boards on each platform. Step-free access is available on both platforms via ramps from the nearby road. Trains operate to Kirkby in one direction and to Manchester Victoria via Wigan Wallgate in the other every hour; the last train of the day continues to Blackburn. There is no late evening service on a Sunday. A normal service operates on most bank holidays. Marshall, J. Forgotten Railways North-West England, David & Charles Ltd, Newton Abbott. ISBN 0-7153-8003-6 Butt, R. V. J. Directory of Railway Stations, Patrick Stephens Ltd, Yeovil. ISBN 1-85260-508-1 Train times and station information for Rainford railway station from National Rail The station on an 1888-1913 Overlay OS Map via National Library of Scotland
Aureolaria, with the common name false foxgloves, is a genus of 8 species, native to North America. Aureolaria plants are hemiparasitic, a character that in part describes the family Orobanchaceae; until the genus was aligned with members of the family Scrophulariaceae. As a result of numerous molecular phylogenetic studies based on various chloroplast DNA loci, it was shown to be more related to members of the Orobanchaceae. Aureolaria flava Aureolaria grandiflora Aureolaria greggii Aureolaria levigata Aureolaria patula Aureolaria pectinata Aureolaria pedicularia Aureolaria virginica Media related to Aureolaria at Wikimedia Commons Data related to Aureolaria at Wikispecies
The Bishop of Bath and Wells heads the Church of England Diocese of Bath and Wells in the Province of Canterbury in England. The present diocese covers the overwhelmingly greater part of the county of Somerset and a small area of Dorset; the Episcopal seat is located in the Cathedral Church of Saint Andrew in the city of Wells in Somerset. The bishop is one of two; the current bishop, since his confirmation of election on 4 March 2014, is Peter Hancock, the seventy-eighth Bishop, who signs Peter Bath: et Well:. He took up his duties upon his installation in a service at Wells Cathedral on 7 June 2014; the see had been vacant since Peter Price's retirement on 30 June 2013, during which time Peter Maurice had acted as diocesan bishop. The Bishop's residence is Wells. In late 2013 the Church Commissioners announced that they were purchasing the Old Rectory, a Grade II-listed building in Croscombe for the Bishop's residence; however this decision was opposed, including by the Diocese, in May 2014 was overturned by a committee of the Archbishops' Council.
Somerset came under the authority of the Bishop of Sherborne, but Wells became the seat of its own Bishop of Wells from 909. King William Rufus granted Bath to a royal physician, John of Tours, Bishop of Wells and Abbot of Bath, permitted to move his episcopal seat for Somerset from Wells to Bath in 1090, thereby becoming the first Bishop of Bath, he planned and began a much larger church as his cathedral, to, attached a priory, with the bishop's palace beside it. In 1197 Bishop Savaric FitzGeldewin moved his seat to Glastonbury Abbey with the approval of Pope Celestine III. However, the monks there would not accept their new Bishop of Glastonbury and the title of Bishop of Bath and Glastonbury was used until the Glastonbury claim was abandoned in 1219, his successor, Jocelin of Wells returned to Bath, again under the title, Bishop of Bath. The official episcopal title became Bishop of Bath and Wells under a Papal ruling of 3 January 1245. By the 15th century Bath Abbey was badly dilapidated.
Oliver King, Bishop of Bath and Wells, decided in 1500 to rebuild it on a smaller scale. The new abbey-church was completed just a few years before Bath Priory was dissolved in 1539. Henry VIII considered this new church redundant, it was offered to the people of Bath to form their parish church; the last bishop in communion with Rome was deprived in 1559 but the succession of bishops has continued to the present day. The diocese and the episcopate are today part of the Anglican Communion. A fictional bishop of this title appears in the BBC television comedy Blackadder, in which the bishop is portrayed as an obese, self-confessed pervert who eats children. Others are mentioned in at least two skits by Monty Python and yet another in the BBC radio comedy Absolute Power. Neil Gaiman's 2008 work The Graveyard Book features a character named the Bishop of Bath and Wells – he is one of a trio of ghouls who spirit the main character away. Among those who have served as assistant bishops of the diocese are: late 1860s: James Chapman, Coadjutor-Bishop, Rector of Wootton Courtenay, a Prebendary of Wells and former Bishop of Colombo 1891–1900: Charles Bromby, former Bishop of Tasmania 1950–1967: Fabian Jackson, Rector of Batcombe and former Bishop of Trinidad Official Diocese of Bath & Wells Website Episcopal succession: Wells