Interstate 290 (I-290) is an auxiliary Interstate Highway in the US state of Massachusetts, maintained by the Massachusetts Department of Transportation (MassDOT). Spanning approximately 20 miles (32 km), it is signed as an east–west spur route of I-90 in Central Massachusetts. The route begins in Auburn at I-90 as a northward continuation of I-395. It follows an L-shaped route, the nominally western half of which runs north into the city of Worcester, and, upon leaving the city, turns to the east to its eastern terminus at I-495 in Marlborough. Past I-495, the road continues as the Route 85 Connector to the town of Hudson. The route serves as the main freeway route through Worcester, as well as being part of a longer distance travel corridor through New England, connecting Connecticut and Western Massachusetts with much of New Hampshire and Maine.

The Massachusetts Turnpike is a tolled controlled-access highway in the US state of Massachusetts that is maintained by the Massachusetts Department of Transportation (MassDOT). It is concurrent with the entirety of Interstate 90 (I-90) within the state, and is the longest Interstate Highway in Massachusetts, spanning 138 miles (222 km) along an east–west axis.