Interstate 495 (I-495) is an auxiliary route of I-95 in the US state of Massachusetts, maintained by the Massachusetts Department of Transportation (MassDOT). Spanning 121.56 miles (195.63 km), it is the second-longest auxiliary route in the Interstate Highway System, being roughly 11 miles (18 km) shorter than I-476 in Pennsylvania.

Interstate 95 (I-95) is a part of the Interstate Highway System that parallels the East Coast of the United States from Miami, Florida, in the south to Houlton, Maine, in the north. In the US state of Massachusetts, it spans 92 miles (148 km) along a north–south axis. It is the third-longest Interstate Highway in Massachusetts, behind I-90 and I-495, while I-95 in full is the longest north–south Interstate and sixth-longest Interstate Highway in the US.