Interstate 587 (I-587) is a 37.07-mile (59.66 km) auxiliary Interstate Highway in the US state of North Carolina. The western terminus of the highway is at I-95, I-795, and US Highway 264 (US 264) near Wilson. The highway runs concurrently with I-795 and US 264 around the southern side of Wilson. I-795 diverges toward Goldsboro 4.4 miles (7.1 km) east of I-95. The eastern end of the US 264 overlap is located northwest of Saratoga. I-587 continues travelling east, bypassing Saratoga and Farmville to the north. The eastern terminus of I-587 is located at US 264 and North Carolina Highway 11 Bypass in western Greenville. I-587 is a spur of the North Carolina segment of I-87 which runs from Raleigh to Wendell. As of 2024, I-587 does not connect with its parent route.

Interstate 95 (I-95) is a part of the Interstate Highway System that runs along the East Coast of the United States from Miami, Florida, to the Canada–United States border at Houlton, Maine. In the state of North Carolina, the route runs for 181.36 miles (291.87 km) from the South Carolina border near Rowland to the Virginia border near Pleasant Hill. The highway serves the cities of Lumberton, Fayetteville, Wilson, Rocky Mount, and Roanoke Rapids. The route goes through a mostly rural area of the state, avoiding most of the major metro areas of North Carolina. It forms the informal border between the Piedmont and Atlantic Plain regions of the state.