Iowa Highway 44 (Iowa 44) is an east–west highway in the central and west-central portions of the state. It runs parallel to Interstate 80, which runs 10 miles (16 km) to the south for most of Iowa 44's route. Iowa 44 begins at its junction with U.S. Highway 30 four miles (6 km) northeast of Logan. It ends at an interchange with the Iowa Highway 141 freeway at Grimes. Iowa 44 was created in 1969 when Iowa Highway 64 was shortened to its current route in eastern Iowa. Most of the route is a part of the Western Skies Scenic Byway.

Iowa Highway 141 (Iowa 141) is an east–west highway in the western and central portions of the state. It is the most direct link between Sioux City and Des Moines. It also serves as an expressway link between Des Moines and the outlying communities of Perry, Granger, and Grimes. Iowa 141 begins near Sloan at an interchange with Interstate 29 (I-29) at ends at another interchange with I-35 /I-80 on the edge of the Des Moines suburbs of Urbandale and Grimes.