Thomas Jefferson High School, usually referred to as Jefferson High School, is a public high school in the Los Angeles Unified School District. Founded in 1916, it is the fourth oldest high school in the school district. Located in South Los Angeles, its surrounding communities are Downtown, Central-Alameda, Florence, Historic South-Central and South Park. Jefferson's school colors are kelly green and gold and the sports teams are called the Democrats, or Demos for short. In 2006, a pilot program called New Tech: Student Empowerment Academy began in the northeast portion of the school. New Tech has since become a separate charter school housed in the Jefferson building. In 2016 New Tech closed down and the available space is now used by Nava College Preparatory Academy a pilot school that was established in 2014.

South Los Angeles, also known as South Central Los Angeles or simply South Central, is a region in southwestern Los Angeles County, California, lying mostly within the city limits of Los Angeles, south of downtown. It is "defined on Los Angeles city maps as a 16-square-mile (41 km2) rectangle with two prongs at the south end.” In 2003, the Los Angeles City Council renamed this area "South Los Angeles".