John Doukas, Latinized as Ducas, was the eldest son of Constantine Angelos by Theodora Komnene, the seventh child of the Byzantine Emperor Alexios I Komnenos and Irene Doukaina. John Doukas took the family name of his grandmother Irene. He served as a military commander under Manuel I Komnenos and Isaac II Angelos. Isaac II, who was Doukas's nephew, raised him to the high rank of sebastokrator. Despite his advanced age, he continued to be an active general in the 1180s and 1190s, and until shortly before his death aspired to the imperial throne. He was the progenitor of the Komnenos Doukas line, which founded the Despotate of Epirus after the Fourth Crusade.

Irene Doukaina or Ducaena was a Byzantine empress by marriage to the Byzantine emperor Alexios I Komnenos. She was the mother of Emperor John II Komnenos and the historian Anna Komnene. She was initially heavily overshadowed and humiliated in influence and power by her mother-in-law Anna Dalassene, but after her retirement and death, Irene was able to exert increasing influence over her husband Alexios I Komnenos, and became powerful towards the end of his reign. But even so, she could not arrange his successor according to her wishes, which favoured her daughter Anna Komnene over her son John II Komnenos.