Washington University in St. Louis
Washington University in St. Louis is a private research university in St. Louis, Missouri. Founded in 1853, named after George Washington, the university has students and faculty from all 50 U. S. states and more than 120 countries. As of 2017, 24 Nobel laureates in economics and medicine, physics have been affiliated with Washington University, nine having done the major part of their pioneering research at the university. Washington University's undergraduate program is ranked 19th by U. S. News & World Report in 2018 and 11th by The Wall Street Journal in their 2018 rankings; the university is ranked 20th in the world in 2018 by the Academic Ranking of World Universities. The acceptance rate for the class of 2023 was 14%, with students selected from more than 31,000 applications. Of students admitted 90 percent were in the top 10 percent of their class. Washington University is made up of seven graduate and undergraduate schools that encompass a broad range of academic fields. To prevent confusion over its location, the Board of Trustees added the phrase "in St. Louis" in 1976.
Washington University was conceived by 17 St. Louis business and religious leaders concerned by the lack of institutions of higher learning in the Midwest. Missouri State Senator Wayman Crow and Unitarian minister William Greenleaf Eliot, grandfather of the poet T. S. Eliot, led the effort; the university's first chancellor was Joseph Gibson Hoyt. Crow secured the university charter from the Missouri General Assembly in 1853, Eliot was named President of the Board of Trustees. Early on, Eliot solicited support from members of the local business community, including John O'Fallon, but Eliot failed to secure a permanent endowment. Washington University is unusual among major American universities in not having had a prior financial endowment; the institution had no backing of a religious organization, single wealthy patron, or earmarked government support. During the three years following its inception, the university bore three different names; the board first approved "Eliot Seminary," but William Eliot was uncomfortable with naming a university after himself and objected to the establishment of a seminary, which would implicitly be charged with teaching a religious faith.
He favored a nonsectarian university. In 1854, the Board of Trustees changed the name to "Washington Institute" in honor of George Washington. Naming the University after the nation's first president, only seven years before the American Civil War and during a time of bitter national division, was no coincidence. During this time of conflict, Americans universally admired George Washington as the father of the United States and a symbol of national unity; the Board of Trustees believed that the university should be a force of unity in a divided Missouri. In 1856, the University amended its name to "Washington University." The university amended its name once more in 1976, when the Board of Trustees voted to add the suffix "in St. Louis" to distinguish the university from the nearly two dozen other universities bearing Washington's name. Although chartered as a university, for many years Washington University functioned as a night school located on 17th Street and Washington Avenue in the heart of downtown St. Louis.
Owing to limited financial resources, Washington University used public buildings. Classes began on October 1854, at the Benton School building. At first the university paid for the evening classes, but as their popularity grew, their funding was transferred to the St. Louis Public Schools; the board secured funds for the construction of Academic Hall and a half dozen other buildings. The university divided into three departments: the Manual Training School, Smith Academy, the Mary Institute. In 1867, the university opened the first private nonsectarian law school west of the Mississippi River. By 1882, Washington University had expanded to numerous departments, which were housed in various buildings across St. Louis. Medical classes were first held at Washington University in 1891 after the St. Louis Medical College decided to affiliate with the University, establishing the School of Medicine. During the 1890s, Robert Sommers Brookings, the president of the Board of Trustees, undertook the tasks of reorganizing the university's finances, putting them onto a sound foundation, buying land for a new campus.
Washington University spent its first half century in downtown St. Louis bounded by Washington Ave. Lucas Place, Locust Street. By the 1890s, owing to the dramatic expansion of the Manual School and a new benefactor in Robert Brookings, the University began to move west; the University board of directors began a process to find suitable ground and hired the landscape architecture firm Olmsted, Olmsted & Eliot of Boston. A committee of Robert S. Brookings, Henry Ware Eliot, William Huse found a site of 103 acres just beyond Forest Park, located west of the city limits in St. Louis County; the elevation of the land was thought to resemble the Acropolis and inspired the nickname of "Hilltop" campus, renamed the Danforth campus in 2006 to honor former chancellor William H. Danforth. In 1899, the university opened a national design contest for the new campus; the renowned Philadelphia firm Cope & Stewardson won unanimously with its plan for a row of Collegiate Gothic quadrangles inspired by Oxford and Cambridge Universities.
The cornerstone of the first building, Busch Hall, was laid on October 20, 1900. The construction of Brookings Hall and Cupples began shortly thereafter; the school delayed occupying these buildings until 1905 to accommodate the 1904 World's Fair and Olympics. The delay allowed the university to construct ten buildings instead of t
Nutrition is the science that interprets the interaction of nutrients and other substances in food in relation to maintenance, reproduction and disease of an organism. It includes food intake, assimilation, biosynthesis and excretion; the diet of an organism is what it eats, determined by the availability and palatability of foods. For humans, a healthy diet includes preparation of food and storage methods that preserve nutrients from oxidation, heat or leaching, that reduce risk of foodborne illnesses. In humans, an unhealthy diet can cause deficiency-related diseases such as blindness, scurvy, preterm birth and cretinism, or nutrient excess health-threatening conditions such as obesity and metabolic syndrome. Undernutrition can lead to wasting in acute cases, the stunting of marasmus in chronic cases of malnutrition; the first recorded dietary advice, carved into a Babylonian stone tablet in about 2500 BC, cautioned those with pain inside to avoid eating onions for three days. Scurvy found to be a vitamin C deficiency, was first described in 1500 BC in the Ebers Papyrus.
According to Walter Gratzer, the study of nutrition began during the 6th century BC. In China, the concept of qi developed, a spirit or "wind" similar to what Western Europeans called pneuma. Food was classified into "hot" and "cold" in China, India and Persia. Humours developed first in China alongside qi. Ho the Physician concluded that diseases are caused by deficiencies of elements, he classified diseases as well as prescribed diets. About the same time in Italy, Alcmaeon of Croton wrote of the importance of equilibrium between what goes in and what goes out, warned that imbalance would result in disease marked by obesity or emaciation; the first recorded nutritional experiment with human subjects is found in the Bible's Book of Daniel. Daniel and his friends were captured by the king of Babylon during an invasion of Israel. Selected as court servants, they were to share in the king's fine foods and wine, but they objected, preferring vegetables and water in accordance with their Jewish dietary restrictions.
The king's chief steward reluctantly agreed to a trial. Daniel and his friends received their diet for ten days and were compared to the king's men. Appearing healthier, they were allowed to continue with their diet. Around 475 BC, Anaxagoras stated that food is absorbed by the human body and, contains "homeomerics", suggesting the existence of nutrients. Around 400 BC, who recognized and was concerned with obesity, which may have been common in southern Europe at the time, said, "Let food be your medicine and medicine be your food." The works that are still attributed to him, Corpus Hippocraticum, called for moderation and emphasized exercise. Salt and other spices were prescribed for various ailments in various preparations for example mixed with vinegar. In the 2nd century BC, Cato the Elder believed that cabbage could cure digestive diseases, ulcers and intoxication. Living about the turn of the millennium, Aulus Celsus, an ancient Roman doctor, believed in "strong" and "weak" foods. One mustn't overlook the doctrines of Galen: In use from his life in the 1st century AD until the 17th century, it was heresy to disagree with him for 1500 years.
Galen was physician to gladiators in Pergamon, in Rome, physician to Marcus Aurelius and the three emperors who succeeded him. Most of Galen's teachings were gathered and enhanced in the late 11th century by Benedictine monks at the School of Salerno in Regimen sanitatis Salernitanum, which still had users in the 17th century. Galen believed in the bodily humours of Hippocrates, he taught that pneuma is the source of life. Four elements combine into "complexion"; the states are made up of pairs of attributes, which are made of four humours: blood, green bile, black bile. Galen thought that for a person to have gout, kidney stones, or arthritis was scandalous, which Gratzer likens to Samuel Butler's Erehwon where sickness is a crime. In the 1500s, Paracelsus was the first to criticize Galen publicly. In the 16th century and artist Leonardo da Vinci compared metabolism to a burning candle. Leonardo did not publish his works on this subject, but he was not afraid of thinking for himself and he disagreed with Galen.
16th century works of Andreas Vesalius, sometimes called the father of modern human anatomy, overturned Galen's ideas. He was followed by piercing thought amalgamated with the era's mysticism and religion sometimes fueled by the mechanics of Newton and Galileo. Jan Baptist van Helmont, who discovered several gases such as carbon dioxide, performed the first quantitative experiment. Robert Boyle advanced chemistry. Sanctorius measured body weight. Physician Herman Boerhaave modeled the digestive process. Physiologist Albrecht von Haller worked out the difference between muscles. Sometimes forgotten during his life, James Lind, a physician in the British navy, performed the first scientific nutrition experiment in 1747. Lind discovered that lime juice saved sailors, at sea for years from scurvy, a deadly an
Cerebrospinal fluid is a clear, colorless body fluid found in the brain and spinal cord. It is produced by the specialised ependymal cells in the choroid plexuses of the ventricles of the brain, absorbed in the arachnoid granulations. There is about 125mL of CSF at any one time, about 500 mL is generated every day. CSF acts as a cushion or buffer for the brain, providing basic mechanical and immunological protection to the brain inside the skull. CSF serves a vital function in cerebral autoregulation of cerebral blood flow. CSF occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord, it fills the ventricles of the brain and sulci, as well as the central canal of the spinal cord. There is a connection from the subarachnoid space to the bony labyrinth of the inner ear via the perilymphatic duct where the perilymph is continuous with the cerebrospinal fluid. A sample of CSF can be taken via lumbar puncture; this can reveal the intracranial pressure, as well as indicate diseases including infections of the brain or its surrounding meninges.
Although noted by Hippocrates, it was only in the 18th century that Emanuel Swedenborg is credited with its rediscovery, as late as 1914 that Harvey W. Cushing demonstrated CSF was secreted by the choroid plexus. There is about 125–150 mL of CSF at any one time; this CSF circulates within the ventricular system of the brain. The ventricles are a series of cavities filled with CSF; the majority of CSF is produced from within the two lateral ventricles. From here, CSF passes through the interventricular foramina to the third ventricle the cerebral aqueduct to the fourth ventricle. From the fourth ventricle, the fluid passes into the subarachnoid space through four openings – the central canal of the spinal cord, the median aperture, the two lateral apertures. CSF is present within the subarachnoid space, which covers the brain, spinal cord, stretches below the end of the spinal cord to the sacrum. There is a connection from the subarachnoid space to the bony labyrinth of the inner ear making the cerebrospinal fluid continuous with the perilymph in 93% of people.
CSF moves in a single outward direction from the ventricles, but multidirectionally in the subarachnoid space. Fluid movement is pulsatile, matching the pressure waves generated in blood vessels by the beating of the heart; some authors dispute this, posing that there is no unidirectional CSF circulation, but cardiac cycle-dependent bi-directional systolic-diastolic to-and-fro cranio-spinal CSF movements. CSF is derived from blood plasma and is similar to it, except that CSF is nearly protein-free compared with plasma and has some different electrolyte levels. Due to the way it is produced, CSF has a higher chloride level than plasma, an equivalent sodium level. CSF contains 0.3% plasma proteins, or 15 to 40 mg/dL, depending on sampling site. In general, globular proteins and albumin are in lower concentration in ventricular CSF compared to lumbar or cisternal fluid; this continuous flow into the venous system dilutes the concentration of larger, lipid-insoluble molecules penetrating the brain and CSF.
CSF is free of red blood cells, at most contains only a few white blood cells. Any white blood cell count higher. At around the third week of development, the embryo is a three-layered disc, covered with ectoderm and endoderm. A tube-like formation develops in the midline, called the notochord; the notochord releases extracellular molecules that affect the transformation of the overlying ectoderm into nervous tissue. The neural tube, forming from the ectoderm, contains CSF prior to the development of the choroid plexuses; the open neuropores of the neural tube close after the first month of development, CSF pressure increases. As the brain develops, by the fourth week of embryological development three swellings have formed within the embryo around the canal, near where the head will develop; these swellings represent different components of the central nervous system: the prosencephalon and rhombencephalon. Subarachnoid spaces are first evident around the 32nd day of development near the rhombencephalon.
At this time, the first choroid plexus can be seen, found in the fourth ventricle, although the time at which they first secrete CSF is not yet known. The developing forebrain surrounds the neural cord; as the forebrain develops, the neural cord within it becomes a ventricle forming the lateral ventricles. Along the inner surface of both ventricles, the ventricular wall remains thin, a choroid plexus develops and releasing CSF. CSF fills the neural canal. Arachnoid villi are formed around the 35th week of development, with aracnhoid granulations noted around the 39th, continuing developing until 18 months of age; the subcommissural organ secretes SCO-spondin, which forms Reissner's fiber within CSF assisting movement through the cerebral aqueduct. It disappears during early development. CSF serves several purposes: Buoyancy: The actual mass of the human brain is about 1400–1500 grams; the brain therefore exists in neutral buoyancy, which allows the brain to maintain its density without being impaired by its own weight, which would cut off blood supply and kill neurons in the lower sections without CSF.
Protection: CSF protects the brain tissue from injury when jolted or hit, by providing a fluid buffer that acts as a shock absorber from some forms of mechanical injury. Prevention of brain ischemia: The prevention of brai
Harvard University is a private Ivy League research university in Cambridge, with about 6,700 undergraduate students and about 15,250 postgraduate students. Established in 1636 and named for its first benefactor, clergyman John Harvard, Harvard is the United States' oldest institution of higher learning, its history and wealth have made it one of the world's most prestigious universities; the Harvard Corporation is its first chartered corporation. Although never formally affiliated with any denomination, the early College trained Congregational and Unitarian clergy, its curriculum and student body were secularized during the 18th century, by the 19th century, Harvard had emerged as the central cultural establishment among Boston elites. Following the American Civil War, President Charles W. Eliot's long tenure transformed the college and affiliated professional schools into a modern research university. A. Lawrence Lowell, who followed Eliot, further reformed the undergraduate curriculum and undertook aggressive expansion of Harvard's land holdings and physical plant.
James Bryant Conant led the university through the Great Depression and World War II and began to reform the curriculum and liberalize admissions after the war. The undergraduate college became coeducational after its 1977 merger with Radcliffe College; the university is organized into eleven separate academic units—ten faculties and the Radcliffe Institute for Advanced Study—with campuses throughout the Boston metropolitan area: its 209-acre main campus is centered on Harvard Yard in Cambridge 3 miles northwest of Boston. Harvard's endowment is worth $39.2 billion, making it the largest of any academic institution. Harvard is a large residential research university; the nominal cost of attendance is high, but the university's large endowment allows it to offer generous financial aid packages. The Harvard Library is the world's largest academic and private library system, comprising 79 individual libraries holding over 18 million items; the University is cited as one of the world's top tertiary institutions by various organizations.
Harvard's alumni include eight U. S. presidents, more than thirty foreign heads of state, 62 living billionaires, 359 Rhodes Scholars, 242 Marshall Scholars. As of October 2018, 158 Nobel laureates, 18 Fields Medalists, 14 Turing Award winners have been affiliated as students, faculty, or researchers. In addition, Harvard students and alumni have won 10 Academy Awards, 48 Pulitzer Prizes and 108 Olympic medals, have founded a large number of companies worldwide. Harvard was established in 1636 by vote of the Great and General Court of the Massachusetts Bay Colony. In 1638, it acquired British North America's first known printing press. In 1639, it was named Harvard College after deceased clergyman John Harvard, an alumnus of the University of Cambridge, who had left the school £779 and his scholar's library of some 400 volumes; the charter creating the Harvard Corporation was granted in 1650. A 1643 publication gave the school's purpose as "to advance learning and perpetuate it to posterity, dreading to leave an illiterate ministry to the churches when our present ministers shall lie in the dust".
It offered a classic curriculum on the English university model—many leaders in the colony had attended the University of Cambridge—but conformed to the tenets of Puritanism. It was never affiliated with any particular denomination, but many of its earliest graduates went on to become clergymen in Congregational and Unitarian churches; the leading Boston divine Increase Mather served as president from 1685 to 1701. In 1708, John Leverett became the first president, not a clergyman, marking a turning of the college from Puritanism and toward intellectual independence. Throughout the 18th century, Enlightenment ideas of the power of reason and free will became widespread among Congregational ministers, putting those ministers and their congregations in tension with more traditionalist, Calvinist parties; when the Hollis Professor of Divinity David Tappan died in 1803 and the president of Harvard Joseph Willard died a year in 1804, a struggle broke out over their replacements. Henry Ware was elected to the chair in 1805, the liberal Samuel Webber was appointed to the presidency of Harvard two years which signaled the changing of the tide from the dominance of traditional ideas at Harvard to the dominance of liberal, Arminian ideas.
In 1846, the natural history lectures of Louis Agassiz were acclaimed both in New York and on the campus at Harvard College. Agassiz's approach was distinctly idealist and posited Americans' "participation in the Divine Nature" and the possibility of understanding "intellectual existences". Agassiz's perspective on science combined observation with intuition and the assumption that a person can grasp the "divine plan" in all phenomena; when it came to explaining life-forms, Agassiz resorted to matters of shape based on a presumed archetype for his evidence. This dual view of knowledge was in concert with the teachings of Common Sense Realism derived from Scottish philosophers Thomas Reid and Dugald Stewart, whose works were part of the Harvard curriculum at the time; the popularity of Agassiz's efforts to "soar with Plato" also derived from other writings to which Harvard students
Union University (New York)
Union University is a federation of several graduate and undergraduate institutions which are located in New York State, United States. Its constituent entities include Albany College of Pharmacy, Albany Law School, Albany Medical College, Dudley Observatory, Union Graduate College, Union College, it was established in 1873. The motto on its seal is In necessariis unitas, in dubiis libertas, in omnibus caritas; each member institution has its own governing board, is fiscally independent, is responsible for its own programs
Johns Hopkins Hospital
The Johns Hopkins Hospital is the teaching hospital and biomedical research facility of the Johns Hopkins School of Medicine, located in Baltimore, Maryland, U. S, it was founded in 1889 using money from a bequest of over $7 million by city merchant, banker/financier, civic leader and philanthropist Johns Hopkins. Johns Hopkins Hospital and its school of medicine are considered to be the founding institutions of modern American medicine and the birthplace of numerous famous medical traditions including rounds and house staff. Many medical specialties were formed by Dr. Harvey Cushing. Johns Hopkins Hospital is regarded as one of the world's greatest hospitals and medical institutions, it was ranked by U. S. News & World Report news magazine as the best overall hospital in America for 21 consecutive years. In 2017-2018, the hospital ranked in 15 adult and 10 children's specialties, coming in 1st in Maryland and 3rd nationally behind the Mayo Clinic in Rochester and the Cleveland Clinic in Cleveland, Ohio.
Johns Hopkins, a Baltimore merchant and banker, left an estate of $7 million when he died on Christmas Eve, December 24, 1873, in his city mansion on West Saratoga Street, just west of North Charles Street, at the age of 78. In his will, he asked that his fortune be used to found two institutions that would bear his name: "Johns Hopkins University" and "The Johns Hopkins Hospital." At the time that it was made, Hopkins's gift was the largest philanthropic bequest in the history of the United States. Toward the end of his life, Hopkins selected 12 prominent Baltimoreans to be the trustees for the project and a year before his death, sent a letter telling them that he was giving "thirteen acres of land, situated in the city of Baltimore, bounded by Broadway, Wolfe and Jefferson streets upon which I desire you to erect a hospital." He wished for a hospital "which shall, in construction and arrangement, compare favorably with any other institution of like character in this country or in Europe" and directed his trustees to "secure for the service of the Hospital and surgeons of the highest character and greatest skill."Most Hopkins told the trustees to "bear in mind that it is my wish and purpose that the hospital shall form a part of the Medical School of that university for which I have made ample provision in my will."
By calling for this integral relationship between patient care, as embodied in the hospital, teaching and research, as embodied in the university, Hopkins laid the groundwork for a revolution in American medicine. Johns Hopkins' vision, of two institutions in which the practice of medicine would be wedded to medical research and medical education was nothing short of revolutionary. Initial plans for the hospital were drafted by surgeon John Shaw Billings, the architecture designed by John Rudolph Niernsee and completed by Edward Clarke Cabot of the Boston firm of Cabot and Chandler in a Queen Anne style; when completed in 1889 at a cost of $2,050,000, the hospital included what was state-of-the art concepts in heating and ventilation to check the spread of disease. The trustees obtained the services of four outstanding physicians, known as the "Big Four," to serve as the founding staff of the hospital when it opened on May 7, 1889, they were pathologist William Henry Welch, surgeon William Stewart Halsted, internist William Osler, gynecologist Howard Atwood Kelly.
In 1893, Johns Hopkins University was one of the first medical schools to admit women. The decision to begin coeducation was a result of a shortage of funds, as the B&O Railroad stock, supposed to cover cost was used up in building the hospital in 1889 and the medical school had not yet been built. Four of the original trustees’ daughters offered to raise the money needed to open the school, but only if the school agreed to admit qualified women to the university. After several discussions the trustees agreed to their terms and accepted the financial help of these four women, with only one of the doctors, William Henry Welch resisting. Welch changed his views on coeducation, "The necessity for coeducation in some form," he wrote "becomes more evident the higher the character of the education. In no form of education is this more evident than in that of medicine... we regard coeducation a success. He introduced the idea of bringing medical students into actual patient care early in their training.
Osler's contribution to practical education extends to the creation of "grand rounds", the practice of leading physicians discussing the most difficult cases in front of assembled medical students, for the benefit of patients and students. He once said he hoped his tombstone would say only, "He brought medical students into the wards for bedside teaching."Halsted, the first chief of the Department of Surgery, established many other medical and surgical achievements at Johns Hopkins including modern surgical principles of control of bleeding, accurate anatomical dissection, complete sterility, the first radical mastectomy for breast cancer (before