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Protein LYPLA1 PDB 1fj2.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases LYPLA1, APT-1, APT1, LPL-I, LPL1, hAPT1, lysophospholipase I
External IDs MGI: 1344588 HomoloGene: 100781 GeneCards: LYPLA1
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for LYPLA1
Genomic location for LYPLA1
Band 8q11.23 Start 54,046,367 bp[1]
End 54,102,017 bp[1]
RNA expression pattern
PBB GE LYPLA1 212449 s at fs.png

PBB GE LYPLA1 203007 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 8: 54.05 – 54.1 Mb Chr 8: 4.81 – 4.85 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.[5][6]

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids, the protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120992 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025903 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA (Apr 1999). "A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization". Biochim Biophys Acta. 1437 (2): 157–69. doi:10.1016/s1388-1981(99)00012-8. PMID 10064899. 
  6. ^ a b "Entrez Gene: LYPLA1 lysophospholipase I". 

Further reading[edit]